Bad Smells and Broken DNA: A Tale of Sulfur-Nucleic Acid Cooperation

Hydrogen sulfide (H2S) is a gasotransmitter that exerts numerous physiologic and pathophysiologic effects. Recently, a role for H2S in DNA repair has been identified, where H2S modulates cell cycle checkpoint responses, the DNA dam...

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Autores principales:	Rodney E. Shackelford, Yan Li, Ghali E. Ghali, Christopher G. Kevil
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hydrogen sulfide DNA repair cystathionine β-synthase cystathionine γ-lyase 3-mercaptopyruvate sulfurtransferase ATR Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/766bea7475eb41f18ff0e990ece92f1f
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spelling	oai:doaj.org-article:766bea7475eb41f18ff0e990ece92f1f2021-11-25T16:29:05ZBad Smells and Broken DNA: A Tale of Sulfur-Nucleic Acid Cooperation10.3390/antiox101118202076-3921https://doaj.org/article/766bea7475eb41f18ff0e990ece92f1f2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1820https://doaj.org/toc/2076-3921Hydrogen sulfide (H<sub>2</sub>S) is a gasotransmitter that exerts numerous physiologic and pathophysiologic effects. Recently, a role for H<sub>2</sub>S in DNA repair has been identified, where H<sub>2</sub>S modulates cell cycle checkpoint responses, the DNA damage response (DDR), and mitochondrial and nuclear genomic stability. In addition, several DNA repair proteins modulate cellular H<sub>2</sub>S concentrations and cellular sulfur metabolism and, in turn, are regulated by cellular H<sub>2</sub>S concentrations. Many DDR proteins are now pharmacologically inhibited in targeted cancer therapies. As H<sub>2</sub>S and the enzymes that synthesize it are increased in many human malignancies, it is likely that H<sub>2</sub>S synthesis inhibition by these therapies is an underappreciated aspect of these cancer treatments. Moreover, both H<sub>2</sub>S and DDR protein activities in cancer and cardiovascular diseases are becoming increasingly apparent, implicating a DDR–H<sub>2</sub>S signaling axis in these pathophysiologic processes. Taken together, H<sub>2</sub>S and DNA repair likely play a central and presently poorly understood role in both normal cellular function and a wide array of human pathophysiologic processes. Here, we review the role of H<sub>2</sub>S in DNA repair.Rodney E. ShackelfordYan LiGhali E. GhaliChristopher G. KevilMDPI AGarticlehydrogen sulfideDNA repaircystathionine β-synthasecystathionine γ-lyase3-mercaptopyruvate sulfurtransferaseATRTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1820, p 1820 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hydrogen sulfide DNA repair cystathionine β-synthase cystathionine γ-lyase 3-mercaptopyruvate sulfurtransferase ATR Therapeutics. Pharmacology RM1-950
spellingShingle	hydrogen sulfide DNA repair cystathionine β-synthase cystathionine γ-lyase 3-mercaptopyruvate sulfurtransferase ATR Therapeutics. Pharmacology RM1-950 Rodney E. Shackelford Yan Li Ghali E. Ghali Christopher G. Kevil Bad Smells and Broken DNA: A Tale of Sulfur-Nucleic Acid Cooperation
description	Hydrogen sulfide (H<sub>2</sub>S) is a gasotransmitter that exerts numerous physiologic and pathophysiologic effects. Recently, a role for H<sub>2</sub>S in DNA repair has been identified, where H<sub>2</sub>S modulates cell cycle checkpoint responses, the DNA damage response (DDR), and mitochondrial and nuclear genomic stability. In addition, several DNA repair proteins modulate cellular H<sub>2</sub>S concentrations and cellular sulfur metabolism and, in turn, are regulated by cellular H<sub>2</sub>S concentrations. Many DDR proteins are now pharmacologically inhibited in targeted cancer therapies. As H<sub>2</sub>S and the enzymes that synthesize it are increased in many human malignancies, it is likely that H<sub>2</sub>S synthesis inhibition by these therapies is an underappreciated aspect of these cancer treatments. Moreover, both H<sub>2</sub>S and DDR protein activities in cancer and cardiovascular diseases are becoming increasingly apparent, implicating a DDR–H<sub>2</sub>S signaling axis in these pathophysiologic processes. Taken together, H<sub>2</sub>S and DNA repair likely play a central and presently poorly understood role in both normal cellular function and a wide array of human pathophysiologic processes. Here, we review the role of H<sub>2</sub>S in DNA repair.
format	article
author	Rodney E. Shackelford Yan Li Ghali E. Ghali Christopher G. Kevil
author_facet	Rodney E. Shackelford Yan Li Ghali E. Ghali Christopher G. Kevil
author_sort	Rodney E. Shackelford
title	Bad Smells and Broken DNA: A Tale of Sulfur-Nucleic Acid Cooperation
title_short	Bad Smells and Broken DNA: A Tale of Sulfur-Nucleic Acid Cooperation
title_full	Bad Smells and Broken DNA: A Tale of Sulfur-Nucleic Acid Cooperation
title_fullStr	Bad Smells and Broken DNA: A Tale of Sulfur-Nucleic Acid Cooperation
title_full_unstemmed	Bad Smells and Broken DNA: A Tale of Sulfur-Nucleic Acid Cooperation
title_sort	bad smells and broken dna: a tale of sulfur-nucleic acid cooperation
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/766bea7475eb41f18ff0e990ece92f1f
work_keys_str_mv	AT rodneyeshackelford badsmellsandbrokendnaataleofsulfurnucleicacidcooperation AT yanli badsmellsandbrokendnaataleofsulfurnucleicacidcooperation AT ghalieghali badsmellsandbrokendnaataleofsulfurnucleicacidcooperation AT christophergkevil badsmellsandbrokendnaataleofsulfurnucleicacidcooperation
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Bad Smells and Broken DNA: A Tale of Sulfur-Nucleic Acid Cooperation

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