Endothelial Function in Obese Patients Treated with Bariatric Surgery

Antonio Maria Borzì,1,2,* Carola Buscemi,3,4,* Davide Corleo,3,4 Cristiana Randazzo,3,4 Giuseppe Rosafio,3,4 Gianni Pantuso,5 Silvio Buscemi3,4 1Department of Clinical and Experimental Medicine, Specialization School in Geriatrics, University of Catania, Catania, Italy; 2Specialization Sc...

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Autores principales:	Borzì AM, Buscemi C, Corleo D, Randazzo C, Rosafio G, Pantuso G, Buscemi S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	obesity endothelial function bariatric surgery medical nutrition therapy Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/766ed1b467014c69afe105ea45e8feef
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spelling	oai:doaj.org-article:766ed1b467014c69afe105ea45e8feef2021-12-02T06:08:26ZEndothelial Function in Obese Patients Treated with Bariatric Surgery1178-7007https://doaj.org/article/766ed1b467014c69afe105ea45e8feef2020-02-01T00:00:00Zhttps://www.dovepress.com/endothelial-function-in-obese-patients-treated-with-bariatric-surgery-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Antonio Maria Borzì,1,2,* Carola Buscemi,3,4,* Davide Corleo,3,4 Cristiana Randazzo,3,4 Giuseppe Rosafio,3,4 Gianni Pantuso,5 Silvio Buscemi3,4 1Department of Clinical and Experimental Medicine, Specialization School in Geriatrics, University of Catania, Catania, Italy; 2Specialization School in Geriatrics, Catania, Italy; 3Dipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza (PROMISE), University of Palermo, Palerno, Italy; 4Unit of Malattie Endocrine, del Ricambio e della Nutrizione, Policlinico University Hospital, Palermo, Italy; 5Dipartimento di Discipline Chirurgiche e Odontostomatologiche (DICHIRONS), Unit of Chirurgia Oncologica, Policlinico University Hospital, Palermo, Italy *These authors contributed equally to this workCorrespondence: Silvio BuscemiUnit of Malattie Endocrine, del Ricambio e della Nutrizione, Policlinico University Hospital, Piazza delle cliniche 2, Palermo 90127, ItalyEmail silvio.buscemi@unipa.itPurpose: Bariatric surgery (BS) is becoming an increasingly frequent treatment option especially in people with morbid obesity, demonstrating that it is able to reduce total mortality and cardiovascular (CV) risk. Despite endothelial dysfunction is an essential requisite contributing to atherosclerosis and predicting CV events, only some studies have investigated the effects of BS on endothelial function with controversial results. In this study, the effects of weight loss on endothelial function were investigated in obese patients after BS and compared with patients after medical nutrition treatment (MNT).Patients and Methods: Seventeen obese patients who underwent BS procedures (9 adjustable gastric bands, 3 gastric by-passes and 5 biliopancreatic diversions) were included in the study and compared with 18 obese individuals who underwent MNT. Endothelial function was investigated by flow-mediated dilation (FMD) of the brachial artery. Also, carotid intima-media thickness (c-IMT) was measured as a marker of subclinical atherosclerosis.Results: At the end of follow-up, the mean weight loss was 18.8% in the BS group and 7.0% in the MNT group. After treatment, FMD significantly decreased in the BS group (mean ± SD before: 9.0 ± 4.7; after: 6.1 ± 2.9%; P= 0.04); however, no significant change was observed in the MNT group (before: 9.4 ± 5.8; after: 8.3 ± 5.3; P= 0.41). The modification of endothelial function was negatively correlated with c-IMT change in the BS group (r= − 0.63; P < 0.007).Conclusion: A significant endothelial dysfunction occurred following BS but not after MNT. Furthermore, the decline of endothelial function observed in the BS group might have contributed to atherosclerosis.Keywords: obesity, endothelial function, bariatric surgery, medical nutrition therapyBorzì AMBuscemi CCorleo DRandazzo CRosafio GPantuso GBuscemi SDove Medical Pressarticleobesityendothelial functionbariatric surgerymedical nutrition therapySpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 247-256 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	obesity endothelial function bariatric surgery medical nutrition therapy Specialties of internal medicine RC581-951
spellingShingle	obesity endothelial function bariatric surgery medical nutrition therapy Specialties of internal medicine RC581-951 Borzì AM Buscemi C Corleo D Randazzo C Rosafio G Pantuso G Buscemi S Endothelial Function in Obese Patients Treated with Bariatric Surgery
description	Antonio Maria Borzì,1,2,* Carola Buscemi,3,4,* Davide Corleo,3,4 Cristiana Randazzo,3,4 Giuseppe Rosafio,3,4 Gianni Pantuso,5 Silvio Buscemi3,4 1Department of Clinical and Experimental Medicine, Specialization School in Geriatrics, University of Catania, Catania, Italy; 2Specialization School in Geriatrics, Catania, Italy; 3Dipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza (PROMISE), University of Palermo, Palerno, Italy; 4Unit of Malattie Endocrine, del Ricambio e della Nutrizione, Policlinico University Hospital, Palermo, Italy; 5Dipartimento di Discipline Chirurgiche e Odontostomatologiche (DICHIRONS), Unit of Chirurgia Oncologica, Policlinico University Hospital, Palermo, Italy *These authors contributed equally to this workCorrespondence: Silvio BuscemiUnit of Malattie Endocrine, del Ricambio e della Nutrizione, Policlinico University Hospital, Piazza delle cliniche 2, Palermo 90127, ItalyEmail silvio.buscemi@unipa.itPurpose: Bariatric surgery (BS) is becoming an increasingly frequent treatment option especially in people with morbid obesity, demonstrating that it is able to reduce total mortality and cardiovascular (CV) risk. Despite endothelial dysfunction is an essential requisite contributing to atherosclerosis and predicting CV events, only some studies have investigated the effects of BS on endothelial function with controversial results. In this study, the effects of weight loss on endothelial function were investigated in obese patients after BS and compared with patients after medical nutrition treatment (MNT).Patients and Methods: Seventeen obese patients who underwent BS procedures (9 adjustable gastric bands, 3 gastric by-passes and 5 biliopancreatic diversions) were included in the study and compared with 18 obese individuals who underwent MNT. Endothelial function was investigated by flow-mediated dilation (FMD) of the brachial artery. Also, carotid intima-media thickness (c-IMT) was measured as a marker of subclinical atherosclerosis.Results: At the end of follow-up, the mean weight loss was 18.8% in the BS group and 7.0% in the MNT group. After treatment, FMD significantly decreased in the BS group (mean ± SD before: 9.0 ± 4.7; after: 6.1 ± 2.9%; P= 0.04); however, no significant change was observed in the MNT group (before: 9.4 ± 5.8; after: 8.3 ± 5.3; P= 0.41). The modification of endothelial function was negatively correlated with c-IMT change in the BS group (r= − 0.63; P < 0.007).Conclusion: A significant endothelial dysfunction occurred following BS but not after MNT. Furthermore, the decline of endothelial function observed in the BS group might have contributed to atherosclerosis.Keywords: obesity, endothelial function, bariatric surgery, medical nutrition therapy
format	article
author	Borzì AM Buscemi C Corleo D Randazzo C Rosafio G Pantuso G Buscemi S
author_facet	Borzì AM Buscemi C Corleo D Randazzo C Rosafio G Pantuso G Buscemi S
author_sort	Borzì AM
title	Endothelial Function in Obese Patients Treated with Bariatric Surgery
title_short	Endothelial Function in Obese Patients Treated with Bariatric Surgery
title_full	Endothelial Function in Obese Patients Treated with Bariatric Surgery
title_fullStr	Endothelial Function in Obese Patients Treated with Bariatric Surgery
title_full_unstemmed	Endothelial Function in Obese Patients Treated with Bariatric Surgery
title_sort	endothelial function in obese patients treated with bariatric surgery
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/766ed1b467014c69afe105ea45e8feef
work_keys_str_mv	AT borziam endothelialfunctioninobesepatientstreatedwithbariatricsurgery AT buscemic endothelialfunctioninobesepatientstreatedwithbariatricsurgery AT corleod endothelialfunctioninobesepatientstreatedwithbariatricsurgery AT randazzoc endothelialfunctioninobesepatientstreatedwithbariatricsurgery AT rosafiog endothelialfunctioninobesepatientstreatedwithbariatricsurgery AT pantusog endothelialfunctioninobesepatientstreatedwithbariatricsurgery AT buscemis endothelialfunctioninobesepatientstreatedwithbariatricsurgery
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Endothelial Function in Obese Patients Treated with Bariatric Surgery

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