Traditional Chinese medicine Yisui Tongjing relieved neural severity in experimental autoimmune neuritis rat model

Erli Zhang,1 Mingquan Li,2 Jianjun Zhao,2 Yuxiang Dong,1 Xueqin Yang,1 Jingbo Huang1 1Department of Traditional Chinese Medicine, The First Bethune Hospital of Jilin University, 2Department of Encephalopathy, The First Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Chan...

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Autores principales:	Zhang E, Li M, Zhao J, Dong Y, Yang X, Huang J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Yisui Tongjing experimental autoimmune neuritis motor nerve conduction velocity sciatic nerve demyelination Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/7673d5a3bbdd42929729e35d5a90458a
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spelling	oai:doaj.org-article:7673d5a3bbdd42929729e35d5a90458a2021-12-02T02:46:56ZTraditional Chinese medicine Yisui Tongjing relieved neural severity in experimental autoimmune neuritis rat model1178-2021https://doaj.org/article/7673d5a3bbdd42929729e35d5a90458a2016-09-01T00:00:00Zhttps://www.dovepress.com/traditional-chinese-medicine-yisui-tongjing-relieved-neural-severity-i-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Erli Zhang,1 Mingquan Li,2 Jianjun Zhao,2 Yuxiang Dong,1 Xueqin Yang,1 Jingbo Huang1 1Department of Traditional Chinese Medicine, The First Bethune Hospital of Jilin University, 2Department of Encephalopathy, The First Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, People’s Republic of China Objective: To study the effect of Yisui Tongjing (YSTJ) prescription on motor nerve conduction velocity (MNCV) and microstructure of the sciatic nerve in experimental autoimmune neuritis (EAN) rats, the Guillain–Barré syndrome classic animal models.Materials and methods: In this study, we established an EAN model in Lewis rats by immunization. We evaluated the potential clinical application of a traditional Chinese medicine YSTJ by intragastric administration and compared its effect with immunoglobulin. The sciatic MNCV was measured by electrophysiology experiment. Hematoxylin–eosin staining and transmission electron microscope analysis were used to determine the pathologically morphological changes before and after YSTJ application.Results: We found that application of YSTJ could significantly alleviate the clinical signs in EAN rats. The treatment also increased MNCV in the sciatic nerve compared to that in the untreated nerve. Demyelination in the sciatic nerve in EAN rats was significantly ameliorated, and newly generated myelinated nerve fibers were observed with treatment of high dose of YSTJ.Conclusion: This study showed that the traditional Chinese medicine YSTJ was likely to serve as a therapeutic medicine in autoimmune neuropathies, providing an effective and economic means to the treatment of Guillain–Barré syndrome. Keywords: Yisui Tongjing, experimental autoimmune neuritis, motor nerve conduction velocity, sciatic nerve, demyelinationZhang ELi MZhao JDong YYang XHuang JDove Medical PressarticleYisui Tongjingexperimental autoimmune neuritismotor nerve conduction velocitysciatic nervedemyelinationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 12, Pp 2481-2487 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Yisui Tongjing experimental autoimmune neuritis motor nerve conduction velocity sciatic nerve demyelination Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Yisui Tongjing experimental autoimmune neuritis motor nerve conduction velocity sciatic nerve demyelination Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Zhang E Li M Zhao J Dong Y Yang X Huang J Traditional Chinese medicine Yisui Tongjing relieved neural severity in experimental autoimmune neuritis rat model
description	Erli Zhang,1 Mingquan Li,2 Jianjun Zhao,2 Yuxiang Dong,1 Xueqin Yang,1 Jingbo Huang1 1Department of Traditional Chinese Medicine, The First Bethune Hospital of Jilin University, 2Department of Encephalopathy, The First Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, People’s Republic of China Objective: To study the effect of Yisui Tongjing (YSTJ) prescription on motor nerve conduction velocity (MNCV) and microstructure of the sciatic nerve in experimental autoimmune neuritis (EAN) rats, the Guillain–Barré syndrome classic animal models.Materials and methods: In this study, we established an EAN model in Lewis rats by immunization. We evaluated the potential clinical application of a traditional Chinese medicine YSTJ by intragastric administration and compared its effect with immunoglobulin. The sciatic MNCV was measured by electrophysiology experiment. Hematoxylin–eosin staining and transmission electron microscope analysis were used to determine the pathologically morphological changes before and after YSTJ application.Results: We found that application of YSTJ could significantly alleviate the clinical signs in EAN rats. The treatment also increased MNCV in the sciatic nerve compared to that in the untreated nerve. Demyelination in the sciatic nerve in EAN rats was significantly ameliorated, and newly generated myelinated nerve fibers were observed with treatment of high dose of YSTJ.Conclusion: This study showed that the traditional Chinese medicine YSTJ was likely to serve as a therapeutic medicine in autoimmune neuropathies, providing an effective and economic means to the treatment of Guillain–Barré syndrome. Keywords: Yisui Tongjing, experimental autoimmune neuritis, motor nerve conduction velocity, sciatic nerve, demyelination
format	article
author	Zhang E Li M Zhao J Dong Y Yang X Huang J
author_facet	Zhang E Li M Zhao J Dong Y Yang X Huang J
author_sort	Zhang E
title	Traditional Chinese medicine Yisui Tongjing relieved neural severity in experimental autoimmune neuritis rat model
title_short	Traditional Chinese medicine Yisui Tongjing relieved neural severity in experimental autoimmune neuritis rat model
title_full	Traditional Chinese medicine Yisui Tongjing relieved neural severity in experimental autoimmune neuritis rat model
title_fullStr	Traditional Chinese medicine Yisui Tongjing relieved neural severity in experimental autoimmune neuritis rat model
title_full_unstemmed	Traditional Chinese medicine Yisui Tongjing relieved neural severity in experimental autoimmune neuritis rat model
title_sort	traditional chinese medicine yisui tongjing relieved neural severity in experimental autoimmune neuritis rat model
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/7673d5a3bbdd42929729e35d5a90458a
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Traditional Chinese medicine Yisui Tongjing relieved neural severity in experimental autoimmune neuritis rat model

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