Two-Step Approach Using Degradable Magnesium to Inhibit Surface Biofilm and Subsequently Kill Planktonic Bacteria

Bacterial infection remains a great risk in medical implantation surgery. In this paper, we found that degradable metals may be a feasible alternative option of antibacterial implantation materials. It is known that the spalling mechanism of magnesium (Mg) during degradation leads to Mg ions-induced...

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Autores principales:	Pei-Chun Wong, Ren-Yi Wang, Long-Sheng Lu, Wei-Ru Wang, Jason Shian-Ching Jang, Jia-Lin Wu, Tai-Yuan Su, Ling-Hua Chang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	bacterial infection magnesium biodegradation spalling biofilm alkaline Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/767433062cf34a84a84aba0de21e8e40
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spelling	oai:doaj.org-article:767433062cf34a84a84aba0de21e8e402021-11-25T16:50:43ZTwo-Step Approach Using Degradable Magnesium to Inhibit Surface Biofilm and Subsequently Kill Planktonic Bacteria10.3390/biomedicines91116772227-9059https://doaj.org/article/767433062cf34a84a84aba0de21e8e402021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1677https://doaj.org/toc/2227-9059Bacterial infection remains a great risk in medical implantation surgery. In this paper, we found that degradable metals may be a feasible alternative option of antibacterial implantation materials. It is known that the spalling mechanism of magnesium (Mg) during degradation leads to Mg ions-induced alkaline environment, which is harmful to planktonic bacteria. In this study, we showed that alkaline pH environment is almost harmless to those adhesive bacteria protected in well-formed biofilms. Moreover, experimental results demonstrated that the biofilm formed in the place where Mg spalls are destroyed, releasing the covered bacteria to be planktonic in the alkaline environment. As a result, the colonization of biofilms continues to shrink during the degradation of Mg. It implies that if degradable metal is employed as implantation material, even if bacterial infection occurs, it may be possibly cured without second surgery.Pei-Chun WongRen-Yi WangLong-Sheng LuWei-Ru WangJason Shian-Ching JangJia-Lin WuTai-Yuan SuLing-Hua ChangMDPI AGarticlebacterial infectionmagnesiumbiodegradationspallingbiofilmalkalineBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1677, p 1677 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bacterial infection magnesium biodegradation spalling biofilm alkaline Biology (General) QH301-705.5
spellingShingle	bacterial infection magnesium biodegradation spalling biofilm alkaline Biology (General) QH301-705.5 Pei-Chun Wong Ren-Yi Wang Long-Sheng Lu Wei-Ru Wang Jason Shian-Ching Jang Jia-Lin Wu Tai-Yuan Su Ling-Hua Chang Two-Step Approach Using Degradable Magnesium to Inhibit Surface Biofilm and Subsequently Kill Planktonic Bacteria
description	Bacterial infection remains a great risk in medical implantation surgery. In this paper, we found that degradable metals may be a feasible alternative option of antibacterial implantation materials. It is known that the spalling mechanism of magnesium (Mg) during degradation leads to Mg ions-induced alkaline environment, which is harmful to planktonic bacteria. In this study, we showed that alkaline pH environment is almost harmless to those adhesive bacteria protected in well-formed biofilms. Moreover, experimental results demonstrated that the biofilm formed in the place where Mg spalls are destroyed, releasing the covered bacteria to be planktonic in the alkaline environment. As a result, the colonization of biofilms continues to shrink during the degradation of Mg. It implies that if degradable metal is employed as implantation material, even if bacterial infection occurs, it may be possibly cured without second surgery.
format	article
author	Pei-Chun Wong Ren-Yi Wang Long-Sheng Lu Wei-Ru Wang Jason Shian-Ching Jang Jia-Lin Wu Tai-Yuan Su Ling-Hua Chang
author_facet	Pei-Chun Wong Ren-Yi Wang Long-Sheng Lu Wei-Ru Wang Jason Shian-Ching Jang Jia-Lin Wu Tai-Yuan Su Ling-Hua Chang
author_sort	Pei-Chun Wong
title	Two-Step Approach Using Degradable Magnesium to Inhibit Surface Biofilm and Subsequently Kill Planktonic Bacteria
title_short	Two-Step Approach Using Degradable Magnesium to Inhibit Surface Biofilm and Subsequently Kill Planktonic Bacteria
title_full	Two-Step Approach Using Degradable Magnesium to Inhibit Surface Biofilm and Subsequently Kill Planktonic Bacteria
title_fullStr	Two-Step Approach Using Degradable Magnesium to Inhibit Surface Biofilm and Subsequently Kill Planktonic Bacteria
title_full_unstemmed	Two-Step Approach Using Degradable Magnesium to Inhibit Surface Biofilm and Subsequently Kill Planktonic Bacteria
title_sort	two-step approach using degradable magnesium to inhibit surface biofilm and subsequently kill planktonic bacteria
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/767433062cf34a84a84aba0de21e8e40
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Two-Step Approach Using Degradable Magnesium to Inhibit Surface Biofilm and Subsequently Kill Planktonic Bacteria

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