Genetic Evidence for SecY Translocon-Mediated Import of Two Contact-Dependent Growth Inhibition (CDI) Toxins

Many bacterial species interact via direct cell-to-cell contact using CDI systems, which provide a mechanism to inject toxins that inhibit bacterial growth into one another. Here, we find that two CDI toxins, one that depolarizes membranes and another that degrades RNA, exploit the universally cons...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Allison M. Jones, Petra Virtanen, Disa Hammarlöf, William J. Allen, Ian Collinson, Christopher S. Hayes, David A. Low, Sanna Koskiniemi
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/76773c4bb4574092b66f55466e261feb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:76773c4bb4574092b66f55466e261feb
record_format	dspace
spelling	oai:doaj.org-article:76773c4bb4574092b66f55466e261feb2021-11-03T18:15:37ZGenetic Evidence for SecY Translocon-Mediated Import of Two Contact-Dependent Growth Inhibition (CDI) Toxins2161-21292150-751110.1128/mBio.03367-20https://doaj.org/article/76773c4bb4574092b66f55466e261feb2021-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.03367-20https://doaj.org/toc/2161-2129https://doaj.org/toc/2150-7511 Many bacterial species interact via direct cell-to-cell contact using CDI systems, which provide a mechanism to inject toxins that inhibit bacterial growth into one another. Here, we find that two CDI toxins, one that depolarizes membranes and another that degrades RNA, exploit the universally conserved SecY translocon machinery used to export proteins for target cell entry.Allison M. JonesPetra VirtanenDisa HammarlöfWilliam J. AllenIan CollinsonChristopher S. HayesDavid A. LowSanna KoskiniemiAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Allison M. Jones Petra Virtanen Disa Hammarlöf William J. Allen Ian Collinson Christopher S. Hayes David A. Low Sanna Koskiniemi Genetic Evidence for SecY Translocon-Mediated Import of Two Contact-Dependent Growth Inhibition (CDI) Toxins
description	Many bacterial species interact via direct cell-to-cell contact using CDI systems, which provide a mechanism to inject toxins that inhibit bacterial growth into one another. Here, we find that two CDI toxins, one that depolarizes membranes and another that degrades RNA, exploit the universally conserved SecY translocon machinery used to export proteins for target cell entry.
format	article
author	Allison M. Jones Petra Virtanen Disa Hammarlöf William J. Allen Ian Collinson Christopher S. Hayes David A. Low Sanna Koskiniemi
author_facet	Allison M. Jones Petra Virtanen Disa Hammarlöf William J. Allen Ian Collinson Christopher S. Hayes David A. Low Sanna Koskiniemi
author_sort	Allison M. Jones
title	Genetic Evidence for SecY Translocon-Mediated Import of Two Contact-Dependent Growth Inhibition (CDI) Toxins
title_short	Genetic Evidence for SecY Translocon-Mediated Import of Two Contact-Dependent Growth Inhibition (CDI) Toxins
title_full	Genetic Evidence for SecY Translocon-Mediated Import of Two Contact-Dependent Growth Inhibition (CDI) Toxins
title_fullStr	Genetic Evidence for SecY Translocon-Mediated Import of Two Contact-Dependent Growth Inhibition (CDI) Toxins
title_full_unstemmed	Genetic Evidence for SecY Translocon-Mediated Import of Two Contact-Dependent Growth Inhibition (CDI) Toxins
title_sort	genetic evidence for secy translocon-mediated import of two contact-dependent growth inhibition (cdi) toxins
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/76773c4bb4574092b66f55466e261feb
work_keys_str_mv	AT allisonmjones geneticevidenceforsecytransloconmediatedimportoftwocontactdependentgrowthinhibitioncditoxins AT petravirtanen geneticevidenceforsecytransloconmediatedimportoftwocontactdependentgrowthinhibitioncditoxins AT disahammarlof geneticevidenceforsecytransloconmediatedimportoftwocontactdependentgrowthinhibitioncditoxins AT williamjallen geneticevidenceforsecytransloconmediatedimportoftwocontactdependentgrowthinhibitioncditoxins AT iancollinson geneticevidenceforsecytransloconmediatedimportoftwocontactdependentgrowthinhibitioncditoxins AT christophershayes geneticevidenceforsecytransloconmediatedimportoftwocontactdependentgrowthinhibitioncditoxins AT davidalow geneticevidenceforsecytransloconmediatedimportoftwocontactdependentgrowthinhibitioncditoxins AT sannakoskiniemi geneticevidenceforsecytransloconmediatedimportoftwocontactdependentgrowthinhibitioncditoxins
_version_	1718445463208722432

Genetic Evidence for SecY Translocon-Mediated Import of Two Contact-Dependent Growth Inhibition (CDI) Toxins

Ejemplares similares