Sexual Adverse Effects and Erectile Dysfunction During Buprenorphine/Naloxone Combination Treatment for Opioid Use Disorders

Engin Emrem Bestepe, Nazlı Tunali, Gökçe Elif Sarıdoğan Department of Psychiatry, Erenkoy Mental Health and Neurological Diseases Training and Research Hospital, University of Health Sciences, Istanbul, TurkeyCorrespondence: Gökçe Elif SarıdoğanDepartment of P...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Bestepe EE, Tunali N, Sarıdoğan GE
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	buprenorphine maintenance turkey substance-related disorders men methadone Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/76791385ec7041bc8f35907c58c1a57f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:76791385ec7041bc8f35907c58c1a57f
record_format	dspace
spelling	oai:doaj.org-article:76791385ec7041bc8f35907c58c1a57f2021-12-02T15:19:08ZSexual Adverse Effects and Erectile Dysfunction During Buprenorphine/Naloxone Combination Treatment for Opioid Use Disorders1178-2021https://doaj.org/article/76791385ec7041bc8f35907c58c1a57f2020-11-01T00:00:00Zhttps://www.dovepress.com/sexual-adverse-effects-and-erectile-dysfunction-during-buprenorphinena-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Engin Emrem Bestepe, Nazlı Tunali, Gökçe Elif Sarıdoğan Department of Psychiatry, Erenkoy Mental Health and Neurological Diseases Training and Research Hospital, University of Health Sciences, Istanbul, TurkeyCorrespondence: Gökçe Elif SarıdoğanDepartment of Psychiatry, Erenkoy Mental Health and Neurological Diseases Training and Research Hospital, University of Health Sciences, Sinan Ercan Cad. No: 23 Kazasker, Istanbul 34736, TurkeyTel +90 532 503 27 97Email drgokcesaridogan@gmail.comBackground and Objectives: Compliance and maintenance of abstinence is a major issue in substance use disorders. Adverse effects of opioid maintenance treatments (OMT) include sexual dysfunctions. There is a vast amount of studies regarding sexual adverse effects of conventional OMTs; however, information regarding buprenorphine/naloxone (Bup/Nal) combination is limited, mostly evaluated in western populations and controversial. In this study, we aimed to assess the sexual adversities of Bup/Nal treatment in a Turkish alcohol and substance use disorder treatment center sample.Materials and Methods: We recruited 100 subjects continuing sublingual Bup/Nal combination and 35 control subjects. Subjects were evaluated via the the Golombok-Rust Inventory of Sexual Satisfaction (GRISS) for sexual dysfunction and for erectile dysfunction (ED) with the International Index of Erectile Function-5 (IIEF-5) as a comparison.Results: The mean dose of our treatment was 9.05. Overall sexual dysfunction scores were not significantly different in between groups with GRISS. ED and noncommunication scores were significantly higher in the Bup/Nal treatment group than the control group (p = 0.002, p = 0.02, respectively). Along with the increased ED scores in GRISS, IIEF-5 total scores also revealed more significant severity of the ED in the Bup/Nal group (p = 0.001).Conclusion: Buprenorphine/naloxone combination lead to a higher degree of ED severity than the non-treatment controls. Noncommunication seems to play a role as a risk factor for ED in patients with opioid use disorder. Thus, effective communication can be a key factor for sexual assertivity and disclosing the sexual adverse effects to the clinicians as well as staying in the treatment.Keywords: buprenorphine maintenance, Turkey, substance-related disorders, men, methadoneBestepe EETunali NSarıdoğan GEDove Medical Pressarticlebuprenorphine maintenanceturkeysubstance-related disordersmenmethadoneNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 2695-2705 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	buprenorphine maintenance turkey substance-related disorders men methadone Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	buprenorphine maintenance turkey substance-related disorders men methadone Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Bestepe EE Tunali N Sarıdoğan GE Sexual Adverse Effects and Erectile Dysfunction During Buprenorphine/Naloxone Combination Treatment for Opioid Use Disorders
description	Engin Emrem Bestepe, Nazlı Tunali, Gökçe Elif Sarıdoğan Department of Psychiatry, Erenkoy Mental Health and Neurological Diseases Training and Research Hospital, University of Health Sciences, Istanbul, TurkeyCorrespondence: Gökçe Elif SarıdoğanDepartment of Psychiatry, Erenkoy Mental Health and Neurological Diseases Training and Research Hospital, University of Health Sciences, Sinan Ercan Cad. No: 23 Kazasker, Istanbul 34736, TurkeyTel +90 532 503 27 97Email drgokcesaridogan@gmail.comBackground and Objectives: Compliance and maintenance of abstinence is a major issue in substance use disorders. Adverse effects of opioid maintenance treatments (OMT) include sexual dysfunctions. There is a vast amount of studies regarding sexual adverse effects of conventional OMTs; however, information regarding buprenorphine/naloxone (Bup/Nal) combination is limited, mostly evaluated in western populations and controversial. In this study, we aimed to assess the sexual adversities of Bup/Nal treatment in a Turkish alcohol and substance use disorder treatment center sample.Materials and Methods: We recruited 100 subjects continuing sublingual Bup/Nal combination and 35 control subjects. Subjects were evaluated via the the Golombok-Rust Inventory of Sexual Satisfaction (GRISS) for sexual dysfunction and for erectile dysfunction (ED) with the International Index of Erectile Function-5 (IIEF-5) as a comparison.Results: The mean dose of our treatment was 9.05. Overall sexual dysfunction scores were not significantly different in between groups with GRISS. ED and noncommunication scores were significantly higher in the Bup/Nal treatment group than the control group (p = 0.002, p = 0.02, respectively). Along with the increased ED scores in GRISS, IIEF-5 total scores also revealed more significant severity of the ED in the Bup/Nal group (p = 0.001).Conclusion: Buprenorphine/naloxone combination lead to a higher degree of ED severity than the non-treatment controls. Noncommunication seems to play a role as a risk factor for ED in patients with opioid use disorder. Thus, effective communication can be a key factor for sexual assertivity and disclosing the sexual adverse effects to the clinicians as well as staying in the treatment.Keywords: buprenorphine maintenance, Turkey, substance-related disorders, men, methadone
format	article
author	Bestepe EE Tunali N Sarıdoğan GE
author_facet	Bestepe EE Tunali N Sarıdoğan GE
author_sort	Bestepe EE
title	Sexual Adverse Effects and Erectile Dysfunction During Buprenorphine/Naloxone Combination Treatment for Opioid Use Disorders
title_short	Sexual Adverse Effects and Erectile Dysfunction During Buprenorphine/Naloxone Combination Treatment for Opioid Use Disorders
title_full	Sexual Adverse Effects and Erectile Dysfunction During Buprenorphine/Naloxone Combination Treatment for Opioid Use Disorders
title_fullStr	Sexual Adverse Effects and Erectile Dysfunction During Buprenorphine/Naloxone Combination Treatment for Opioid Use Disorders
title_full_unstemmed	Sexual Adverse Effects and Erectile Dysfunction During Buprenorphine/Naloxone Combination Treatment for Opioid Use Disorders
title_sort	sexual adverse effects and erectile dysfunction during buprenorphine/naloxone combination treatment for opioid use disorders
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/76791385ec7041bc8f35907c58c1a57f
work_keys_str_mv	AT bestepeee sexualadverseeffectsanderectiledysfunctionduringbuprenorphinenaloxonecombinationtreatmentforopioidusedisorders AT tunalin sexualadverseeffectsanderectiledysfunctionduringbuprenorphinenaloxonecombinationtreatmentforopioidusedisorders AT sarıdogange sexualadverseeffectsanderectiledysfunctionduringbuprenorphinenaloxonecombinationtreatmentforopioidusedisorders
_version_	1718387453080895488

Sexual Adverse Effects and Erectile Dysfunction During Buprenorphine/Naloxone Combination Treatment for Opioid Use Disorders

Ejemplares similares