Brain-Restricted Inhibition of IL-6 Trans-Signaling Mildly Affects Metabolic Consequences of Maternal Obesity in Male Offspring

Brain-Restricted Inhibition of IL-6 Trans-Signaling Mildly Affects Metabolic Consequences of Maternal Obesity in Male Offspring

Maternal obesity greatly affects next generations, elevating obesity risk in the offspring through perinatal programming and flawed maternal and newborn nutrition. The exact underlying mechanisms are poorly understood. Interleukin-6 (IL-6) mediates its effects through a membrane-bound receptor or by...

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Autores principales: Saida Breuer, Philipp Kasper, Christina Vohlen, Ruth Janoschek, Thorben Hoffmann, Sarah Appel, Elena Müller-Limberger, Andrea Mesaros, Stefan Rose-John, Christoph Garbers, Stefan Müller, Jan-Wilm Lackmann, Esther Mahabir, Jörg Dötsch, Eva Hucklenbruch-Rother, Inga Bae-Gartz
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
perinatal programming
maternal nutrition
newborn nutrition
IL-6-trans-signaling
hypothalamic dysfunction
prevention
Nutrition. Foods and food supply
TX341-641
Acceso en línea:https://doaj.org/article/7679340d997c4ce0b91e13159dad4118
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