Visual personal familiarity in amnestic mild cognitive impairment.

<h4>Background</h4>Patients with amnestic mild cognitive impairment are at high risk for developing Alzheimer's disease. Besides episodic memory dysfunction they show deficits in accessing contextual knowledge that further specifies a general concept or helps to identify an object o...

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Autores principales:	Luisa Jurjanz, Markus Donix, Eva C Amanatidis, Shirin Meyer, Katrin Poettrich, Thomas Huebner, Damaris Baeumler, Michael N Smolka, Vjera A Holthoff
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/76794c8e9ab2437d8d89963ac3b6a726
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spelling	oai:doaj.org-article:76794c8e9ab2437d8d89963ac3b6a7262021-11-18T06:53:31ZVisual personal familiarity in amnestic mild cognitive impairment.1932-620310.1371/journal.pone.0020030https://doaj.org/article/76794c8e9ab2437d8d89963ac3b6a7262011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21625502/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Patients with amnestic mild cognitive impairment are at high risk for developing Alzheimer's disease. Besides episodic memory dysfunction they show deficits in accessing contextual knowledge that further specifies a general concept or helps to identify an object or a person.<h4>Methodology/principal findings</h4>Using functional magnetic resonance imaging, we investigated the neural networks associated with the perception of personal familiar faces and places in patients with amnestic mild cognitive impairment and healthy control subjects. Irrespective of stimulus type, patients compared to control subjects showed lower activity in right prefrontal brain regions when perceiving personally familiar versus unfamiliar faces and places. Both groups did not show different neural activity when perceiving faces or places irrespective of familiarity.<h4>Conclusions/significance</h4>Our data highlight changes in a frontal cortical network associated with knowledge-based personal familiarity among patients with amnestic mild cognitive impairment. These changes could contribute to deficits in social cognition and may reduce the patients' ability to transition from basic to complex situations and tasks.Luisa JurjanzMarkus DonixEva C AmanatidisShirin MeyerKatrin PoettrichThomas HuebnerDamaris BaeumlerMichael N SmolkaVjera A HolthoffPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 5, p e20030 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Luisa Jurjanz Markus Donix Eva C Amanatidis Shirin Meyer Katrin Poettrich Thomas Huebner Damaris Baeumler Michael N Smolka Vjera A Holthoff Visual personal familiarity in amnestic mild cognitive impairment.
description	<h4>Background</h4>Patients with amnestic mild cognitive impairment are at high risk for developing Alzheimer's disease. Besides episodic memory dysfunction they show deficits in accessing contextual knowledge that further specifies a general concept or helps to identify an object or a person.<h4>Methodology/principal findings</h4>Using functional magnetic resonance imaging, we investigated the neural networks associated with the perception of personal familiar faces and places in patients with amnestic mild cognitive impairment and healthy control subjects. Irrespective of stimulus type, patients compared to control subjects showed lower activity in right prefrontal brain regions when perceiving personally familiar versus unfamiliar faces and places. Both groups did not show different neural activity when perceiving faces or places irrespective of familiarity.<h4>Conclusions/significance</h4>Our data highlight changes in a frontal cortical network associated with knowledge-based personal familiarity among patients with amnestic mild cognitive impairment. These changes could contribute to deficits in social cognition and may reduce the patients' ability to transition from basic to complex situations and tasks.
format	article
author	Luisa Jurjanz Markus Donix Eva C Amanatidis Shirin Meyer Katrin Poettrich Thomas Huebner Damaris Baeumler Michael N Smolka Vjera A Holthoff
author_facet	Luisa Jurjanz Markus Donix Eva C Amanatidis Shirin Meyer Katrin Poettrich Thomas Huebner Damaris Baeumler Michael N Smolka Vjera A Holthoff
author_sort	Luisa Jurjanz
title	Visual personal familiarity in amnestic mild cognitive impairment.
title_short	Visual personal familiarity in amnestic mild cognitive impairment.
title_full	Visual personal familiarity in amnestic mild cognitive impairment.
title_fullStr	Visual personal familiarity in amnestic mild cognitive impairment.
title_full_unstemmed	Visual personal familiarity in amnestic mild cognitive impairment.
title_sort	visual personal familiarity in amnestic mild cognitive impairment.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/76794c8e9ab2437d8d89963ac3b6a726
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Visual personal familiarity in amnestic mild cognitive impairment.

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