Lack of progression of beta dynamics after long‐term subthalamic neurostimulation

Abstract Objective To investigate the progression of neural and motor features of Parkinson's disease in a longitudinal study, after washout of medication and bilateral subthalamic nucleus deep brain stimulation (STN DBS). Methods Participants with clinically established Parkinson's diseas...

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Autores principales:	Ross W. Anderson, Kevin B. Wilkins, Jordan E. Parker, Matthew N. Petrucci, Yasmine Kehnemouyi, Raumin S. Neuville, Declan Cassini, Megan H. Trager, Mandy M. Koop, Anca Velisar, Zack Blumenfeld, Emma J. Quinn, Jaimie Henderson, Helen M. Bronte‐Stewart
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/76808f91b1b047d3ae1d1d84272d4a10
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spelling	oai:doaj.org-article:76808f91b1b047d3ae1d1d84272d4a102021-11-22T11:11:52ZLack of progression of beta dynamics after long‐term subthalamic neurostimulation2328-950310.1002/acn3.51463https://doaj.org/article/76808f91b1b047d3ae1d1d84272d4a102021-11-01T00:00:00Zhttps://doi.org/10.1002/acn3.51463https://doaj.org/toc/2328-9503Abstract Objective To investigate the progression of neural and motor features of Parkinson's disease in a longitudinal study, after washout of medication and bilateral subthalamic nucleus deep brain stimulation (STN DBS). Methods Participants with clinically established Parkinson's disease underwent bilateral implantation of DBS leads (18 participants, 13 male) within the STN using standard functional frameless stereotactic technique and multi‐pass microelectrode recording. Both DBS leads were connected to an implanted investigative sensing neurostimulator (Activa™ PC + S, Medtronic, PLC). Resting state STN local field potentials (LFPs) were recorded and motor disability, (the Movement Disorder Society‐Unified Parkinson's Disease Rating Scale – motor subscale, MDS‐UPDRS III) was assessed off therapy at initial programming, and after 6 months, 1 year, and yearly out to 5 years of treatment. The primary endpoint was measured at 3 years. At each visit, medication had been held for over 12/24 h and DBS was turned off for at least 60 min, by which time LFP spectra reached a steady state. Results After 3 years of chronic DBS, there were no increases in STN beta band dynamics (p = 0.98) but there were increases in alpha band dynamics (p = 0.0027, 25 STNs). Similar results were observed in a smaller cohort out to 5 years. There was no increase in the MDS‐UPDRS III score. Interpretation These findings provide evidence that the beta oscillopathy does not substantially progress following combined STN DBS plus medication in moderate to advanced Parkinson's disease.Ross W. AndersonKevin B. WilkinsJordan E. ParkerMatthew N. PetrucciYasmine KehnemouyiRaumin S. NeuvilleDeclan CassiniMegan H. TragerMandy M. KoopAnca VelisarZack BlumenfeldEmma J. QuinnJaimie HendersonHelen M. Bronte‐StewartWileyarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENAnnals of Clinical and Translational Neurology, Vol 8, Iss 11, Pp 2110-2120 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Ross W. Anderson Kevin B. Wilkins Jordan E. Parker Matthew N. Petrucci Yasmine Kehnemouyi Raumin S. Neuville Declan Cassini Megan H. Trager Mandy M. Koop Anca Velisar Zack Blumenfeld Emma J. Quinn Jaimie Henderson Helen M. Bronte‐Stewart Lack of progression of beta dynamics after long‐term subthalamic neurostimulation
description	Abstract Objective To investigate the progression of neural and motor features of Parkinson's disease in a longitudinal study, after washout of medication and bilateral subthalamic nucleus deep brain stimulation (STN DBS). Methods Participants with clinically established Parkinson's disease underwent bilateral implantation of DBS leads (18 participants, 13 male) within the STN using standard functional frameless stereotactic technique and multi‐pass microelectrode recording. Both DBS leads were connected to an implanted investigative sensing neurostimulator (Activa™ PC + S, Medtronic, PLC). Resting state STN local field potentials (LFPs) were recorded and motor disability, (the Movement Disorder Society‐Unified Parkinson's Disease Rating Scale – motor subscale, MDS‐UPDRS III) was assessed off therapy at initial programming, and after 6 months, 1 year, and yearly out to 5 years of treatment. The primary endpoint was measured at 3 years. At each visit, medication had been held for over 12/24 h and DBS was turned off for at least 60 min, by which time LFP spectra reached a steady state. Results After 3 years of chronic DBS, there were no increases in STN beta band dynamics (p = 0.98) but there were increases in alpha band dynamics (p = 0.0027, 25 STNs). Similar results were observed in a smaller cohort out to 5 years. There was no increase in the MDS‐UPDRS III score. Interpretation These findings provide evidence that the beta oscillopathy does not substantially progress following combined STN DBS plus medication in moderate to advanced Parkinson's disease.
format	article
author	Ross W. Anderson Kevin B. Wilkins Jordan E. Parker Matthew N. Petrucci Yasmine Kehnemouyi Raumin S. Neuville Declan Cassini Megan H. Trager Mandy M. Koop Anca Velisar Zack Blumenfeld Emma J. Quinn Jaimie Henderson Helen M. Bronte‐Stewart
author_facet	Ross W. Anderson Kevin B. Wilkins Jordan E. Parker Matthew N. Petrucci Yasmine Kehnemouyi Raumin S. Neuville Declan Cassini Megan H. Trager Mandy M. Koop Anca Velisar Zack Blumenfeld Emma J. Quinn Jaimie Henderson Helen M. Bronte‐Stewart
author_sort	Ross W. Anderson
title	Lack of progression of beta dynamics after long‐term subthalamic neurostimulation
title_short	Lack of progression of beta dynamics after long‐term subthalamic neurostimulation
title_full	Lack of progression of beta dynamics after long‐term subthalamic neurostimulation
title_fullStr	Lack of progression of beta dynamics after long‐term subthalamic neurostimulation
title_full_unstemmed	Lack of progression of beta dynamics after long‐term subthalamic neurostimulation
title_sort	lack of progression of beta dynamics after long‐term subthalamic neurostimulation
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/76808f91b1b047d3ae1d1d84272d4a10
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Lack of progression of beta dynamics after long‐term subthalamic neurostimulation

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