Systematic elucidation of neuron-astrocyte interaction in models of amyotrophic lateral sclerosis using multi-modal integrated bioinformatics workflow
Neuron-astrocyte communication plays a key role in pathophysiology, however systematic approaches to unveil it are limited. Here, the authors propose SEARCHIN, a multi-modal integrated workflow, as a tool to identify cross-compartment ligand-receptor interactions, applied to ALS models.
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Nature Portfolio
2020
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oai:doaj.org-article:7681c96b65b048b3a882c2b7968c38642021-12-02T17:31:41ZSystematic elucidation of neuron-astrocyte interaction in models of amyotrophic lateral sclerosis using multi-modal integrated bioinformatics workflow10.1038/s41467-020-19177-y2041-1723https://doaj.org/article/7681c96b65b048b3a882c2b7968c38642020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19177-yhttps://doaj.org/toc/2041-1723Neuron-astrocyte communication plays a key role in pathophysiology, however systematic approaches to unveil it are limited. Here, the authors propose SEARCHIN, a multi-modal integrated workflow, as a tool to identify cross-compartment ligand-receptor interactions, applied to ALS models.Vartika MishraDiane B. ReVirginia Le VercheMariano J. AlvarezAlessandro VasciaveoArnaud JacquierPaschalis-Tomas DouliasTodd M. GrecoMonica NizzardoDimitra PapadimitriouTetsuya NagataPaola RinchettiEduardo J. Perez-TorresKristin A. PolitiBurcin IkizKevin ClareManuel E. ThanStefania CortiHarry IschiropoulosFrancesco LottiAndrea CalifanoSerge PrzedborskiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-20 (2020) |
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DOAJ |
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Science Q |
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Science Q Vartika Mishra Diane B. Re Virginia Le Verche Mariano J. Alvarez Alessandro Vasciaveo Arnaud Jacquier Paschalis-Tomas Doulias Todd M. Greco Monica Nizzardo Dimitra Papadimitriou Tetsuya Nagata Paola Rinchetti Eduardo J. Perez-Torres Kristin A. Politi Burcin Ikiz Kevin Clare Manuel E. Than Stefania Corti Harry Ischiropoulos Francesco Lotti Andrea Califano Serge Przedborski Systematic elucidation of neuron-astrocyte interaction in models of amyotrophic lateral sclerosis using multi-modal integrated bioinformatics workflow |
| description |
Neuron-astrocyte communication plays a key role in pathophysiology, however systematic approaches to unveil it are limited. Here, the authors propose SEARCHIN, a multi-modal integrated workflow, as a tool to identify cross-compartment ligand-receptor interactions, applied to ALS models. |
| format |
article |
| author |
Vartika Mishra Diane B. Re Virginia Le Verche Mariano J. Alvarez Alessandro Vasciaveo Arnaud Jacquier Paschalis-Tomas Doulias Todd M. Greco Monica Nizzardo Dimitra Papadimitriou Tetsuya Nagata Paola Rinchetti Eduardo J. Perez-Torres Kristin A. Politi Burcin Ikiz Kevin Clare Manuel E. Than Stefania Corti Harry Ischiropoulos Francesco Lotti Andrea Califano Serge Przedborski |
| author_facet |
Vartika Mishra Diane B. Re Virginia Le Verche Mariano J. Alvarez Alessandro Vasciaveo Arnaud Jacquier Paschalis-Tomas Doulias Todd M. Greco Monica Nizzardo Dimitra Papadimitriou Tetsuya Nagata Paola Rinchetti Eduardo J. Perez-Torres Kristin A. Politi Burcin Ikiz Kevin Clare Manuel E. Than Stefania Corti Harry Ischiropoulos Francesco Lotti Andrea Califano Serge Przedborski |
| author_sort |
Vartika Mishra |
| title |
Systematic elucidation of neuron-astrocyte interaction in models of amyotrophic lateral sclerosis using multi-modal integrated bioinformatics workflow |
| title_short |
Systematic elucidation of neuron-astrocyte interaction in models of amyotrophic lateral sclerosis using multi-modal integrated bioinformatics workflow |
| title_full |
Systematic elucidation of neuron-astrocyte interaction in models of amyotrophic lateral sclerosis using multi-modal integrated bioinformatics workflow |
| title_fullStr |
Systematic elucidation of neuron-astrocyte interaction in models of amyotrophic lateral sclerosis using multi-modal integrated bioinformatics workflow |
| title_full_unstemmed |
Systematic elucidation of neuron-astrocyte interaction in models of amyotrophic lateral sclerosis using multi-modal integrated bioinformatics workflow |
| title_sort |
systematic elucidation of neuron-astrocyte interaction in models of amyotrophic lateral sclerosis using multi-modal integrated bioinformatics workflow |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/7681c96b65b048b3a882c2b7968c3864 |
| work_keys_str_mv |
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