Left Ventricular Stiffness in Adolescents and Young Adults with Repaired Tetralogy of Fallot

Abstract Left ventricular (LV) remodeling after tetralogy of Fallot (TOF) repair may influence LV stiffness. We hypothesized that LV stiffness is altered after TOF repair and related to myocardial calibrated integrated backscatter (cIB) and LV diastolic myocardial deformation. Seventy-seven TOF pati...

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Autores principales:	Clement Kwong-man Yu, Wilfred Hing-sang Wong, Vivian Wing-yi Li, Yiu-fai Cheung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7685311fc43148f2b3886657998dcc64
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spelling	oai:doaj.org-article:7685311fc43148f2b3886657998dcc642021-12-02T15:06:23ZLeft Ventricular Stiffness in Adolescents and Young Adults with Repaired Tetralogy of Fallot10.1038/s41598-017-01448-22045-2322https://doaj.org/article/7685311fc43148f2b3886657998dcc642017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01448-2https://doaj.org/toc/2045-2322Abstract Left ventricular (LV) remodeling after tetralogy of Fallot (TOF) repair may influence LV stiffness. We hypothesized that LV stiffness is altered after TOF repair and related to myocardial calibrated integrated backscatter (cIB) and LV diastolic myocardial deformation. Seventy-seven TOF patients and 80 controls were studied. LV stiffness was assessed by diastolic wall strain (DWS) as defined by (LVPWsystole-LVPWdiastole)/LVPWsystole, where LVPW is LV posterior wall thickness, and stiffness index as defined by (E/e/LV end-diastolic dimension), where E and e are respectively early diastolic transmitral inflow and mitral annular velocities. Septal and LVPW cIB and LV diastolic strain rates were determined. Patients had significantly lower DWS (p < 0.001), higher stiffness index (p < 0.001), and greater cIB (p < 0.001). LV DWS correlated negatively with LV stiffness index (r = −0.31, p < 0.001), septal cIB (r = −0.21, p = 0.01), E/e ratio (r = −0.30, p < 0.001) and RV end-diastolic area (r = −0.31, p < 0.001), and positively with LV early (r = 0.33, p < 0.001) and late (r = 0.20, p = 0.01) diastolic strain rates and RV fractional area change (FAC) (r = 0.24, p = 0.003). Multivariate analysis revealed E/e (β = −0.26, p = 0.008), RV end-diastolic area (β = −0.20, p = 0.02), and RV FAC (β = 0.18, p = 0.01) as significant correlates of DWS. Left ventricular stiffening occurs after TOF repair and is related to impaired LV diastolic myocardial deformation, myocardial cIB, and RV volume overload.Clement Kwong-man YuWilfred Hing-sang WongVivian Wing-yi LiYiu-fai CheungNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Clement Kwong-man Yu Wilfred Hing-sang Wong Vivian Wing-yi Li Yiu-fai Cheung Left Ventricular Stiffness in Adolescents and Young Adults with Repaired Tetralogy of Fallot
description	Abstract Left ventricular (LV) remodeling after tetralogy of Fallot (TOF) repair may influence LV stiffness. We hypothesized that LV stiffness is altered after TOF repair and related to myocardial calibrated integrated backscatter (cIB) and LV diastolic myocardial deformation. Seventy-seven TOF patients and 80 controls were studied. LV stiffness was assessed by diastolic wall strain (DWS) as defined by (LVPWsystole-LVPWdiastole)/LVPWsystole, where LVPW is LV posterior wall thickness, and stiffness index as defined by (E/e/LV end-diastolic dimension), where E and e are respectively early diastolic transmitral inflow and mitral annular velocities. Septal and LVPW cIB and LV diastolic strain rates were determined. Patients had significantly lower DWS (p < 0.001), higher stiffness index (p < 0.001), and greater cIB (p < 0.001). LV DWS correlated negatively with LV stiffness index (r = −0.31, p < 0.001), septal cIB (r = −0.21, p = 0.01), E/e ratio (r = −0.30, p < 0.001) and RV end-diastolic area (r = −0.31, p < 0.001), and positively with LV early (r = 0.33, p < 0.001) and late (r = 0.20, p = 0.01) diastolic strain rates and RV fractional area change (FAC) (r = 0.24, p = 0.003). Multivariate analysis revealed E/e (β = −0.26, p = 0.008), RV end-diastolic area (β = −0.20, p = 0.02), and RV FAC (β = 0.18, p = 0.01) as significant correlates of DWS. Left ventricular stiffening occurs after TOF repair and is related to impaired LV diastolic myocardial deformation, myocardial cIB, and RV volume overload.
format	article
author	Clement Kwong-man Yu Wilfred Hing-sang Wong Vivian Wing-yi Li Yiu-fai Cheung
author_facet	Clement Kwong-man Yu Wilfred Hing-sang Wong Vivian Wing-yi Li Yiu-fai Cheung
author_sort	Clement Kwong-man Yu
title	Left Ventricular Stiffness in Adolescents and Young Adults with Repaired Tetralogy of Fallot
title_short	Left Ventricular Stiffness in Adolescents and Young Adults with Repaired Tetralogy of Fallot
title_full	Left Ventricular Stiffness in Adolescents and Young Adults with Repaired Tetralogy of Fallot
title_fullStr	Left Ventricular Stiffness in Adolescents and Young Adults with Repaired Tetralogy of Fallot
title_full_unstemmed	Left Ventricular Stiffness in Adolescents and Young Adults with Repaired Tetralogy of Fallot
title_sort	left ventricular stiffness in adolescents and young adults with repaired tetralogy of fallot
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7685311fc43148f2b3886657998dcc64
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_version_	1718388456097316864

Left Ventricular Stiffness in Adolescents and Young Adults with Repaired Tetralogy of Fallot

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