Prognostic value of cardio-hepatic-skeletal muscle syndrome in patients with heart failure

Abstract Although heart failure (HF) and liver dysfunction often coexist because of complex cardiohepatic interactions, the association between liver dysfunction and physical dysfunction, and between coexistence of both and prognosis in HF patients remains unclear. We reviewed 895 patients with HF (...

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Autores principales:	Takumi Noda, Kentaro Kamiya, Nobuaki Hamazaki, Kohei Nozaki, Takafumi Ichikawa, Takeshi Nakamura, Masashi Yamashita, Shota Uchida, Emi Maekawa, Jennifer L. Reed, Minako Yamaoka-Tojo, Atsuhiko Matsunaga, Junya Ako
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/768725f19a4441d69923e1585a278418
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spelling	oai:doaj.org-article:768725f19a4441d69923e1585a2784182021-12-02T13:30:34ZPrognostic value of cardio-hepatic-skeletal muscle syndrome in patients with heart failure10.1038/s41598-020-80641-22045-2322https://doaj.org/article/768725f19a4441d69923e1585a2784182021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80641-2https://doaj.org/toc/2045-2322Abstract Although heart failure (HF) and liver dysfunction often coexist because of complex cardiohepatic interactions, the association between liver dysfunction and physical dysfunction, and between coexistence of both and prognosis in HF patients remains unclear. We reviewed 895 patients with HF (mean age, 69.4 ± 14.2 years) who underwent liver function test using model for end-stage liver disease excluding international normalized ratio (MELD-XI) score and physical function test (grip strength, leg strength, gait speed, and 6-min walking distance [6MWD]). In the multiple regression analysis, MELD-XI score was independently associated with lower grip strength, leg strength, gait speed, and 6MWD (all P < 0.001). One hundred thirty deaths occurred over a median follow-up period of 1.67 years (interquartile range: 0.62–3.04). For all-cause mortality, patients with high MELD-XI scores and reduced physical functions were found to have a significantly higher mortality risk even after adjusting for several covariates (grip strength, hazard ratio [HR]: 3.80, P < 0.001; leg strength, HR: 4.65, P < 0.001; gait speed, HR: 2.49, P = 0.001, and 6MWD, HR: 5.48, P < 0.001). Liver dysfunction was correlated with reduced physical function. Moreover, the coexistence of lower physical function and liver dysfunction considerably affected prognosis in patients with HF.Takumi NodaKentaro KamiyaNobuaki HamazakiKohei NozakiTakafumi IchikawaTakeshi NakamuraMasashi YamashitaShota UchidaEmi MaekawaJennifer L. ReedMinako Yamaoka-TojoAtsuhiko MatsunagaJunya AkoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Takumi Noda Kentaro Kamiya Nobuaki Hamazaki Kohei Nozaki Takafumi Ichikawa Takeshi Nakamura Masashi Yamashita Shota Uchida Emi Maekawa Jennifer L. Reed Minako Yamaoka-Tojo Atsuhiko Matsunaga Junya Ako Prognostic value of cardio-hepatic-skeletal muscle syndrome in patients with heart failure
description	Abstract Although heart failure (HF) and liver dysfunction often coexist because of complex cardiohepatic interactions, the association between liver dysfunction and physical dysfunction, and between coexistence of both and prognosis in HF patients remains unclear. We reviewed 895 patients with HF (mean age, 69.4 ± 14.2 years) who underwent liver function test using model for end-stage liver disease excluding international normalized ratio (MELD-XI) score and physical function test (grip strength, leg strength, gait speed, and 6-min walking distance [6MWD]). In the multiple regression analysis, MELD-XI score was independently associated with lower grip strength, leg strength, gait speed, and 6MWD (all P < 0.001). One hundred thirty deaths occurred over a median follow-up period of 1.67 years (interquartile range: 0.62–3.04). For all-cause mortality, patients with high MELD-XI scores and reduced physical functions were found to have a significantly higher mortality risk even after adjusting for several covariates (grip strength, hazard ratio [HR]: 3.80, P < 0.001; leg strength, HR: 4.65, P < 0.001; gait speed, HR: 2.49, P = 0.001, and 6MWD, HR: 5.48, P < 0.001). Liver dysfunction was correlated with reduced physical function. Moreover, the coexistence of lower physical function and liver dysfunction considerably affected prognosis in patients with HF.
format	article
author	Takumi Noda Kentaro Kamiya Nobuaki Hamazaki Kohei Nozaki Takafumi Ichikawa Takeshi Nakamura Masashi Yamashita Shota Uchida Emi Maekawa Jennifer L. Reed Minako Yamaoka-Tojo Atsuhiko Matsunaga Junya Ako
author_facet	Takumi Noda Kentaro Kamiya Nobuaki Hamazaki Kohei Nozaki Takafumi Ichikawa Takeshi Nakamura Masashi Yamashita Shota Uchida Emi Maekawa Jennifer L. Reed Minako Yamaoka-Tojo Atsuhiko Matsunaga Junya Ako
author_sort	Takumi Noda
title	Prognostic value of cardio-hepatic-skeletal muscle syndrome in patients with heart failure
title_short	Prognostic value of cardio-hepatic-skeletal muscle syndrome in patients with heart failure
title_full	Prognostic value of cardio-hepatic-skeletal muscle syndrome in patients with heart failure
title_fullStr	Prognostic value of cardio-hepatic-skeletal muscle syndrome in patients with heart failure
title_full_unstemmed	Prognostic value of cardio-hepatic-skeletal muscle syndrome in patients with heart failure
title_sort	prognostic value of cardio-hepatic-skeletal muscle syndrome in patients with heart failure
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/768725f19a4441d69923e1585a278418
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Prognostic value of cardio-hepatic-skeletal muscle syndrome in patients with heart failure

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