ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex

The ATR pathway is active during DNA replication stress to maintain genome stability. Here the authors reveal the role of the zinc finger containing protein 161 (ZFP161) to facilitate replication fork stability by acting as a scaffold to facilitate the interaction between RPA and ATR/ATRIP.

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Autores principales:	Wootae Kim, Fei Zhao, Rentian Wu, Sisi Qin, Somaira Nowsheen, Jinzhou Huang, Qin Zhou, Yuping Chen, Min Deng, Guijie Guo, Kuntian Luo, Zhenkun Lou, Jian Yuan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/76873473e9a04e0794d2cfae1d18dfb3
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spelling	oai:doaj.org-article:76873473e9a04e0794d2cfae1d18dfb32021-12-02T16:57:52ZZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex10.1038/s41467-019-13321-z2041-1723https://doaj.org/article/76873473e9a04e0794d2cfae1d18dfb32019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13321-zhttps://doaj.org/toc/2041-1723The ATR pathway is active during DNA replication stress to maintain genome stability. Here the authors reveal the role of the zinc finger containing protein 161 (ZFP161) to facilitate replication fork stability by acting as a scaffold to facilitate the interaction between RPA and ATR/ATRIP.Wootae KimFei ZhaoRentian WuSisi QinSomaira NowsheenJinzhou HuangQin ZhouYuping ChenMin DengGuijie GuoKuntian LuoZhenkun LouJian YuanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wootae Kim Fei Zhao Rentian Wu Sisi Qin Somaira Nowsheen Jinzhou Huang Qin Zhou Yuping Chen Min Deng Guijie Guo Kuntian Luo Zhenkun Lou Jian Yuan ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex
description	The ATR pathway is active during DNA replication stress to maintain genome stability. Here the authors reveal the role of the zinc finger containing protein 161 (ZFP161) to facilitate replication fork stability by acting as a scaffold to facilitate the interaction between RPA and ATR/ATRIP.
format	article
author	Wootae Kim Fei Zhao Rentian Wu Sisi Qin Somaira Nowsheen Jinzhou Huang Qin Zhou Yuping Chen Min Deng Guijie Guo Kuntian Luo Zhenkun Lou Jian Yuan
author_facet	Wootae Kim Fei Zhao Rentian Wu Sisi Qin Somaira Nowsheen Jinzhou Huang Qin Zhou Yuping Chen Min Deng Guijie Guo Kuntian Luo Zhenkun Lou Jian Yuan
author_sort	Wootae Kim
title	ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex
title_short	ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex
title_full	ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex
title_fullStr	ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex
title_full_unstemmed	ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex
title_sort	zfp161 regulates replication fork stability and maintenance of genomic stability by recruiting the atr/atrip complex
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/76873473e9a04e0794d2cfae1d18dfb3
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ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex

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