Study on controlling nicotine release from snus by the SIPN membranes

Snus is one of the types of smokeless tobaccos, which is popular in many countries and regions. The nicotine level in the plasma samples obtained from snus users is similar to the nicotine level obtained from cigarette smokers; hence, the snus users find it difficult to quit. The aim of this study i...

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Autores principales:	Zhan Xiaoping, Jian Xiaopeng, Mao Zhenmin
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	semi-interpenetrating polymer controlling release membrane controlled drug release snus nicotine replacement therapy Polymers and polymer manufacture TP1080-1185
Acceso en línea:	https://doaj.org/article/768851f5a232442ba4f32bd07f85e6db
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spelling	oai:doaj.org-article:768851f5a232442ba4f32bd07f85e6db2021-12-05T14:10:47ZStudy on controlling nicotine release from snus by the SIPN membranes1618-722910.1515/epoly-2021-0048https://doaj.org/article/768851f5a232442ba4f32bd07f85e6db2021-07-01T00:00:00Zhttps://doi.org/10.1515/epoly-2021-0048https://doaj.org/toc/1618-7229Snus is one of the types of smokeless tobaccos, which is popular in many countries and regions. The nicotine level in the plasma samples obtained from snus users is similar to the nicotine level obtained from cigarette smokers; hence, the snus users find it difficult to quit. The aim of this study is to develop new semi-interpenetrating polymer (SIPN) membranes that control the stable release of nicotine from snus, achieving the purpose of quitting smoking. Here, the SIPN comprising a polyacrylate network and PEG chains was synthesized through in situ radical polymerization. The SIPN was characterized by Fourier transform infrared spectroscopy, contact angle, differential scanning calorimetry, scanning electron microscopy, cytotoxicity, and in vitro release experiments. Furthermore, this SIPN was used to evaluate the release properties of nicotine in different snus samples varying in moisture, pH, and the tobacco’s particle size. The results indicated that the new SIPN could control release of nicotine at a specific rate, and the release rate could be adjusted according to the customer requirements. Thus, the new SIPN was contributed to build a new nicotine replacement therapy that served the snus users.Zhan XiaopingJian XiaopengMao ZhenminDe Gruyterarticlesemi-interpenetrating polymercontrolling release membranecontrolled drug releasesnusnicotine replacement therapyPolymers and polymer manufactureTP1080-1185ENe-Polymers, Vol 21, Iss 1, Pp 466-475 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	semi-interpenetrating polymer controlling release membrane controlled drug release snus nicotine replacement therapy Polymers and polymer manufacture TP1080-1185
spellingShingle	semi-interpenetrating polymer controlling release membrane controlled drug release snus nicotine replacement therapy Polymers and polymer manufacture TP1080-1185 Zhan Xiaoping Jian Xiaopeng Mao Zhenmin Study on controlling nicotine release from snus by the SIPN membranes
description	Snus is one of the types of smokeless tobaccos, which is popular in many countries and regions. The nicotine level in the plasma samples obtained from snus users is similar to the nicotine level obtained from cigarette smokers; hence, the snus users find it difficult to quit. The aim of this study is to develop new semi-interpenetrating polymer (SIPN) membranes that control the stable release of nicotine from snus, achieving the purpose of quitting smoking. Here, the SIPN comprising a polyacrylate network and PEG chains was synthesized through in situ radical polymerization. The SIPN was characterized by Fourier transform infrared spectroscopy, contact angle, differential scanning calorimetry, scanning electron microscopy, cytotoxicity, and in vitro release experiments. Furthermore, this SIPN was used to evaluate the release properties of nicotine in different snus samples varying in moisture, pH, and the tobacco’s particle size. The results indicated that the new SIPN could control release of nicotine at a specific rate, and the release rate could be adjusted according to the customer requirements. Thus, the new SIPN was contributed to build a new nicotine replacement therapy that served the snus users.
format	article
author	Zhan Xiaoping Jian Xiaopeng Mao Zhenmin
author_facet	Zhan Xiaoping Jian Xiaopeng Mao Zhenmin
author_sort	Zhan Xiaoping
title	Study on controlling nicotine release from snus by the SIPN membranes
title_short	Study on controlling nicotine release from snus by the SIPN membranes
title_full	Study on controlling nicotine release from snus by the SIPN membranes
title_fullStr	Study on controlling nicotine release from snus by the SIPN membranes
title_full_unstemmed	Study on controlling nicotine release from snus by the SIPN membranes
title_sort	study on controlling nicotine release from snus by the sipn membranes
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/768851f5a232442ba4f32bd07f85e6db
work_keys_str_mv	AT zhanxiaoping studyoncontrollingnicotinereleasefromsnusbythesipnmembranes AT jianxiaopeng studyoncontrollingnicotinereleasefromsnusbythesipnmembranes AT maozhenmin studyoncontrollingnicotinereleasefromsnusbythesipnmembranes
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Study on controlling nicotine release from snus by the SIPN membranes

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