Targeting the Tumor Microenvironment: A Literature Review of the Novel Anti-Tumor Mechanism of Statins

Statins is widely used in clinical practice as lipid-lowering drugs and has been proven to be effective in the treatment of cardiovascular, endocrine, metabolic syndrome and other diseases. The latest preclinical evidence shows that statins have anti-proliferation, pro-apoptotic, anti-invasion and r...

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Autores principales:	Peng-Fei Zhu, Ming-Xing Wang, Zhe-Ling Chen, Liu Yang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	statin HMG-CoA tumor microenvironment pyroptosis ferroptosis autophagy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/7688a2545090455d81defc0d649595e8
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id	oai:doaj.org-article:7688a2545090455d81defc0d649595e8
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spelling	oai:doaj.org-article:7688a2545090455d81defc0d649595e82021-11-11T07:56:49ZTargeting the Tumor Microenvironment: A Literature Review of the Novel Anti-Tumor Mechanism of Statins2234-943X10.3389/fonc.2021.761107https://doaj.org/article/7688a2545090455d81defc0d649595e82021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.761107/fullhttps://doaj.org/toc/2234-943XStatins is widely used in clinical practice as lipid-lowering drugs and has been proven to be effective in the treatment of cardiovascular, endocrine, metabolic syndrome and other diseases. The latest preclinical evidence shows that statins have anti-proliferation, pro-apoptotic, anti-invasion and radiotherapy sensitization effects on tumor cells, suggesting that statins may become a new type of anti-tumor drugs. For a long time, mevalonate pathway has been proved to play a supporting role in the development of tumor cells. As an effective inhibitor of mevalonate pathway, statins have been proved to have a direct auxiliary anti-tumor effect in a large number of studies. In addition, anti-tumor effects of statins through ferroptosis, pyroptosis, autophagy and tumor microenvironment (TME) have also been gradually discovered. However, the specific mechanism of the antitumor effect of statins in the tumor microenvironment has not been clearly elucidated. Herein, we reviewed the antitumor effects of statins in tumor microenvironment, focusing on hypoxia microenvironment, immune microenvironment, metabolic microenvironment, acid microenvironment and mechanical microenvironment.Peng-Fei ZhuPeng-Fei ZhuMing-Xing WangMing-Xing WangZhe-Ling ChenLiu YangLiu YangFrontiers Media S.A.articlestatinHMG-CoAtumor microenvironmentpyroptosisferroptosisautophagyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	statin HMG-CoA tumor microenvironment pyroptosis ferroptosis autophagy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	statin HMG-CoA tumor microenvironment pyroptosis ferroptosis autophagy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Peng-Fei Zhu Peng-Fei Zhu Ming-Xing Wang Ming-Xing Wang Zhe-Ling Chen Liu Yang Liu Yang Targeting the Tumor Microenvironment: A Literature Review of the Novel Anti-Tumor Mechanism of Statins
description	Statins is widely used in clinical practice as lipid-lowering drugs and has been proven to be effective in the treatment of cardiovascular, endocrine, metabolic syndrome and other diseases. The latest preclinical evidence shows that statins have anti-proliferation, pro-apoptotic, anti-invasion and radiotherapy sensitization effects on tumor cells, suggesting that statins may become a new type of anti-tumor drugs. For a long time, mevalonate pathway has been proved to play a supporting role in the development of tumor cells. As an effective inhibitor of mevalonate pathway, statins have been proved to have a direct auxiliary anti-tumor effect in a large number of studies. In addition, anti-tumor effects of statins through ferroptosis, pyroptosis, autophagy and tumor microenvironment (TME) have also been gradually discovered. However, the specific mechanism of the antitumor effect of statins in the tumor microenvironment has not been clearly elucidated. Herein, we reviewed the antitumor effects of statins in tumor microenvironment, focusing on hypoxia microenvironment, immune microenvironment, metabolic microenvironment, acid microenvironment and mechanical microenvironment.
format	article
author	Peng-Fei Zhu Peng-Fei Zhu Ming-Xing Wang Ming-Xing Wang Zhe-Ling Chen Liu Yang Liu Yang
author_facet	Peng-Fei Zhu Peng-Fei Zhu Ming-Xing Wang Ming-Xing Wang Zhe-Ling Chen Liu Yang Liu Yang
author_sort	Peng-Fei Zhu
title	Targeting the Tumor Microenvironment: A Literature Review of the Novel Anti-Tumor Mechanism of Statins
title_short	Targeting the Tumor Microenvironment: A Literature Review of the Novel Anti-Tumor Mechanism of Statins
title_full	Targeting the Tumor Microenvironment: A Literature Review of the Novel Anti-Tumor Mechanism of Statins
title_fullStr	Targeting the Tumor Microenvironment: A Literature Review of the Novel Anti-Tumor Mechanism of Statins
title_full_unstemmed	Targeting the Tumor Microenvironment: A Literature Review of the Novel Anti-Tumor Mechanism of Statins
title_sort	targeting the tumor microenvironment: a literature review of the novel anti-tumor mechanism of statins
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/7688a2545090455d81defc0d649595e8
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Targeting the Tumor Microenvironment: A Literature Review of the Novel Anti-Tumor Mechanism of Statins

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