Kidneys cytomembranes stability in pregnant women with type 1 diabetes and pregnancy outcomes depending on the method of insulin delivery

Objective. To evaluate of kidney cytomembranes stability during pregnancy and its outcomes in patients with diabetes mellitus type on type 1 with different stages of diabetic nephropathy (DN) according to the route of insulin administration. Materials and Methods. We study 100 pregnant women with...

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Autores principales:	Zulfiya Raisovna Alimetova, Farida Vadutovna Valeeva
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2012
Materias:	diabetes mellitus pregnancy renal cytomembranes stability pregnancy outcomes pump portable dispenser Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/768cbceef0d64b9ebf4180691a7f0ffd
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spelling	oai:doaj.org-article:768cbceef0d64b9ebf4180691a7f0ffd2021-11-14T09:00:17ZKidneys cytomembranes stability in pregnant women with type 1 diabetes and pregnancy outcomes depending on the method of insulin delivery2072-03512072-037810.14341/2072-0351-5541https://doaj.org/article/768cbceef0d64b9ebf4180691a7f0ffd2012-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5541https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Objective. To evaluate of kidney cytomembranes stability during pregnancy and its outcomes in patients with diabetes mellitus type on type 1 with different stages of diabetic nephropathy (DN) according to the route of insulin administration. Materials and Methods. We study 100 pregnant women with type 1 diabetes with the introduction of insulin in the mode of multiple subcutaneous injections (MSII) and with portable dispenser with a continuous subcutaneous insulin infusion (CSII). DN stage determined by the level of albumin in the daily urine. Cytomembranes stability assessment conducted on daily excretion of ethanolamine and phospholipids with urine in each trimester. Pregnancy outcomes were analyzed in 52 patients with type 1 diabetes. In the group of pregnant women with delivery at term 38-40 weeks we also analyzed the status of newborns. Results. Indicators of cytomembranes stability of kidneys in pregnant women on CSII consistent with those in healthy pregnant women (p>0.05) the whole pregnancy, regardless of the level of daily urinary albumin excretion. There were no differences in cytomembrana stability of kidneys between the group of patients on MSII with normal albumin excretion (NAU) and the control group regardless to the gestational age (p>0.05). With the introduction of insulin in the mode of MSII on the stage of microalbuminuria (MAU) in the 3rd trimester we found the increase of ethanolamine excretion as compared to control groupy (U=8,00, p=0.012) and the group on CSII with a similar stage of nephropathy (U=2.00, p=0.033). In patients with proteinuria (PU) in the group on the MSII in the third trimester phospholipids excretion is increased with a daily urine (U=27,5, p=0.03 and U=22,00, p=0.07 for patients MSII and CSII, respectively). The use of an insulin pump allowed to prolong gestational period, even in severe proteinuric stage of nephropathy. Manifestations of diabetic fetopathy as macrosomia, hypoglycemia in the fetus at birth time mothers using CSII mode were less common than with MSII (p=0.01 and p=0.04, respectively). In the CSII group no resuscitation was needed, as opposed to 20% of children whose mothers used the MSII. Conclusion. The administration of insulin using portable dispenser the of mode CSII during pregnancy in patients with type 1 diabetes, even at the initial stage of the DN the cytomembranes stability is saved, pregnancy outcomes are improved.Zulfiya Raisovna AlimetovaFarida Vadutovna ValeevaEndocrinology Research Centrearticlediabetes mellituspregnancyrenal cytomembranes stabilitypregnancy outcomespumpportable dispenserNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 15, Iss 4, Pp 69-73 (2012)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus pregnancy renal cytomembranes stability pregnancy outcomes pump portable dispenser Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus pregnancy renal cytomembranes stability pregnancy outcomes pump portable dispenser Nutritional diseases. Deficiency diseases RC620-627 Zulfiya Raisovna Alimetova Farida Vadutovna Valeeva Kidneys cytomembranes stability in pregnant women with type 1 diabetes and pregnancy outcomes depending on the method of insulin delivery
description	Objective. To evaluate of kidney cytomembranes stability during pregnancy and its outcomes in patients with diabetes mellitus type on type 1 with different stages of diabetic nephropathy (DN) according to the route of insulin administration. Materials and Methods. We study 100 pregnant women with type 1 diabetes with the introduction of insulin in the mode of multiple subcutaneous injections (MSII) and with portable dispenser with a continuous subcutaneous insulin infusion (CSII). DN stage determined by the level of albumin in the daily urine. Cytomembranes stability assessment conducted on daily excretion of ethanolamine and phospholipids with urine in each trimester. Pregnancy outcomes were analyzed in 52 patients with type 1 diabetes. In the group of pregnant women with delivery at term 38-40 weeks we also analyzed the status of newborns. Results. Indicators of cytomembranes stability of kidneys in pregnant women on CSII consistent with those in healthy pregnant women (p>0.05) the whole pregnancy, regardless of the level of daily urinary albumin excretion. There were no differences in cytomembrana stability of kidneys between the group of patients on MSII with normal albumin excretion (NAU) and the control group regardless to the gestational age (p>0.05). With the introduction of insulin in the mode of MSII on the stage of microalbuminuria (MAU) in the 3rd trimester we found the increase of ethanolamine excretion as compared to control groupy (U=8,00, p=0.012) and the group on CSII with a similar stage of nephropathy (U=2.00, p=0.033). In patients with proteinuria (PU) in the group on the MSII in the third trimester phospholipids excretion is increased with a daily urine (U=27,5, p=0.03 and U=22,00, p=0.07 for patients MSII and CSII, respectively). The use of an insulin pump allowed to prolong gestational period, even in severe proteinuric stage of nephropathy. Manifestations of diabetic fetopathy as macrosomia, hypoglycemia in the fetus at birth time mothers using CSII mode were less common than with MSII (p=0.01 and p=0.04, respectively). In the CSII group no resuscitation was needed, as opposed to 20% of children whose mothers used the MSII. Conclusion. The administration of insulin using portable dispenser the of mode CSII during pregnancy in patients with type 1 diabetes, even at the initial stage of the DN the cytomembranes stability is saved, pregnancy outcomes are improved.
format	article
author	Zulfiya Raisovna Alimetova Farida Vadutovna Valeeva
author_facet	Zulfiya Raisovna Alimetova Farida Vadutovna Valeeva
author_sort	Zulfiya Raisovna Alimetova
title	Kidneys cytomembranes stability in pregnant women with type 1 diabetes and pregnancy outcomes depending on the method of insulin delivery
title_short	Kidneys cytomembranes stability in pregnant women with type 1 diabetes and pregnancy outcomes depending on the method of insulin delivery
title_full	Kidneys cytomembranes stability in pregnant women with type 1 diabetes and pregnancy outcomes depending on the method of insulin delivery
title_fullStr	Kidneys cytomembranes stability in pregnant women with type 1 diabetes and pregnancy outcomes depending on the method of insulin delivery
title_full_unstemmed	Kidneys cytomembranes stability in pregnant women with type 1 diabetes and pregnancy outcomes depending on the method of insulin delivery
title_sort	kidneys cytomembranes stability in pregnant women with type 1 diabetes and pregnancy outcomes depending on the method of insulin delivery
publisher	Endocrinology Research Centre
publishDate	2012
url	https://doaj.org/article/768cbceef0d64b9ebf4180691a7f0ffd
work_keys_str_mv	AT zulfiyaraisovnaalimetova kidneyscytomembranesstabilityinpregnantwomenwithtype1diabetesandpregnancyoutcomesdependingonthemethodofinsulindelivery AT faridavadutovnavaleeva kidneyscytomembranesstabilityinpregnantwomenwithtype1diabetesandpregnancyoutcomesdependingonthemethodofinsulindelivery
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Kidneys cytomembranes stability in pregnant women with type 1 diabetes and pregnancy outcomes depending on the method of insulin delivery

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