Role of CASP7 polymorphisms in noise-induced hearing loss risk in Han Chinese population

Abstract Genetic factors and gene-environment interaction may play an important role in the development of noise induced hearing loss (NIHL). 191 cases and 191 controls were selected by case–control study. Among them, case groups were screened from workers exposed to noise in binaural high-frequency...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yanmei Ruan, Jinwei Zhang, Shiqi Mai, Wenfeng Zeng, Lili Huang, Chunrong Gu, Keping Liu, Yuying Ma, Zhi Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/768d078bac694b0494af35167475df5b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:768d078bac694b0494af35167475df5b
record_format	dspace
spelling	oai:doaj.org-article:768d078bac694b0494af35167475df5b2021-12-02T13:50:41ZRole of CASP7 polymorphisms in noise-induced hearing loss risk in Han Chinese population10.1038/s41598-021-81391-52045-2322https://doaj.org/article/768d078bac694b0494af35167475df5b2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81391-5https://doaj.org/toc/2045-2322Abstract Genetic factors and gene-environment interaction may play an important role in the development of noise induced hearing loss (NIHL). 191 cases and 191 controls were selected by case–control study. Among them, case groups were screened from workers exposed to noise in binaural high-frequency hearing thresholds greater than 25 dB (A). Workers with hearing thresholds ≤ 25 dB (A) in any binaural frequency band were selected to the control group, based on matching factors such as age, exposure time to noise, and operating position. The blood samples from two groups of workers were subjected to DNA extraction and SNP sequencing of CASP3 and CASP7 genes using the polymerase chain reaction ligase detection reaction method. Conditional logistic regression correction was used to analyze the genetic variation associated with susceptibility to NIHL. There was an association between rs2227310 and rs4353229 of the CASP7 gene and the risk of NIHL. Compared with the GG genotype, the CC genotype of rs2227310 reduced the risk of NIHL. Compared with CC genotype, the TT genotype of rs4353229 reduced the risk of NIHL. Workers carrying the rs2227310GG and rs4353229CC genotype had an increased risk of NIHL compared to workers without any high-risk genotype. There were additive interaction and multiplication interaction between CASP7rs2227310 and CNE, and the same interaction between CASP7rs4353229 and CNE. The interaction between the CASP7 gene and CNE significantly increased the risk of NIHL. The genetic polymorphisms of CASP7rs2227310GG and CASP7rs4353229CC were associated with an increased risk of NIHL in Han Chinese population and have the potential to act as biomarkers for noise-exposed workers.Yanmei RuanJinwei ZhangShiqi MaiWenfeng ZengLili HuangChunrong GuKeping LiuYuying MaZhi WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yanmei Ruan Jinwei Zhang Shiqi Mai Wenfeng Zeng Lili Huang Chunrong Gu Keping Liu Yuying Ma Zhi Wang Role of CASP7 polymorphisms in noise-induced hearing loss risk in Han Chinese population
description	Abstract Genetic factors and gene-environment interaction may play an important role in the development of noise induced hearing loss (NIHL). 191 cases and 191 controls were selected by case–control study. Among them, case groups were screened from workers exposed to noise in binaural high-frequency hearing thresholds greater than 25 dB (A). Workers with hearing thresholds ≤ 25 dB (A) in any binaural frequency band were selected to the control group, based on matching factors such as age, exposure time to noise, and operating position. The blood samples from two groups of workers were subjected to DNA extraction and SNP sequencing of CASP3 and CASP7 genes using the polymerase chain reaction ligase detection reaction method. Conditional logistic regression correction was used to analyze the genetic variation associated with susceptibility to NIHL. There was an association between rs2227310 and rs4353229 of the CASP7 gene and the risk of NIHL. Compared with the GG genotype, the CC genotype of rs2227310 reduced the risk of NIHL. Compared with CC genotype, the TT genotype of rs4353229 reduced the risk of NIHL. Workers carrying the rs2227310GG and rs4353229CC genotype had an increased risk of NIHL compared to workers without any high-risk genotype. There were additive interaction and multiplication interaction between CASP7rs2227310 and CNE, and the same interaction between CASP7rs4353229 and CNE. The interaction between the CASP7 gene and CNE significantly increased the risk of NIHL. The genetic polymorphisms of CASP7rs2227310GG and CASP7rs4353229CC were associated with an increased risk of NIHL in Han Chinese population and have the potential to act as biomarkers for noise-exposed workers.
format	article
author	Yanmei Ruan Jinwei Zhang Shiqi Mai Wenfeng Zeng Lili Huang Chunrong Gu Keping Liu Yuying Ma Zhi Wang
author_facet	Yanmei Ruan Jinwei Zhang Shiqi Mai Wenfeng Zeng Lili Huang Chunrong Gu Keping Liu Yuying Ma Zhi Wang
author_sort	Yanmei Ruan
title	Role of CASP7 polymorphisms in noise-induced hearing loss risk in Han Chinese population
title_short	Role of CASP7 polymorphisms in noise-induced hearing loss risk in Han Chinese population
title_full	Role of CASP7 polymorphisms in noise-induced hearing loss risk in Han Chinese population
title_fullStr	Role of CASP7 polymorphisms in noise-induced hearing loss risk in Han Chinese population
title_full_unstemmed	Role of CASP7 polymorphisms in noise-induced hearing loss risk in Han Chinese population
title_sort	role of casp7 polymorphisms in noise-induced hearing loss risk in han chinese population
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/768d078bac694b0494af35167475df5b
work_keys_str_mv	AT yanmeiruan roleofcasp7polymorphismsinnoiseinducedhearinglossriskinhanchinesepopulation AT jinweizhang roleofcasp7polymorphismsinnoiseinducedhearinglossriskinhanchinesepopulation AT shiqimai roleofcasp7polymorphismsinnoiseinducedhearinglossriskinhanchinesepopulation AT wenfengzeng roleofcasp7polymorphismsinnoiseinducedhearinglossriskinhanchinesepopulation AT lilihuang roleofcasp7polymorphismsinnoiseinducedhearinglossriskinhanchinesepopulation AT chunronggu roleofcasp7polymorphismsinnoiseinducedhearinglossriskinhanchinesepopulation AT kepingliu roleofcasp7polymorphismsinnoiseinducedhearinglossriskinhanchinesepopulation AT yuyingma roleofcasp7polymorphismsinnoiseinducedhearinglossriskinhanchinesepopulation AT zhiwang roleofcasp7polymorphismsinnoiseinducedhearinglossriskinhanchinesepopulation
_version_	1718392444879372288

Role of CASP7 polymorphisms in noise-induced hearing loss risk in Han Chinese population

Ejemplares similares