Role of sex in the association between childhood socioeconomic position and cognitive ageing in later life

Abstract We aimed to explore sex differences in the association of childhood socioeconomic position (SEP) with the level of cognitive performance and the rate of cognitive decline. We studied 84,059 individuals (55% women; mean age 64 years) from the Survey on Health, Ageing and Retirement in Europe...

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Autores principales:	Katrin Wolfova, Zsofia Csajbok, Anna Kagstrom, Ingemar Kåreholt, Pavla Cermakova
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/769092ecd8eb4874b288a60fae17192e
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spelling	oai:doaj.org-article:769092ecd8eb4874b288a60fae17192e2021-12-02T15:53:45ZRole of sex in the association between childhood socioeconomic position and cognitive ageing in later life10.1038/s41598-021-84022-12045-2322https://doaj.org/article/769092ecd8eb4874b288a60fae17192e2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84022-1https://doaj.org/toc/2045-2322Abstract We aimed to explore sex differences in the association of childhood socioeconomic position (SEP) with the level of cognitive performance and the rate of cognitive decline. We studied 84,059 individuals (55% women; mean age 64 years) from the Survey on Health, Ageing and Retirement in Europe. Sex differences in the association of childhood SEP (household characteristics at age 10) with the level of cognitive performance (verbal fluency, immediate recall, delayed recall) were analysed using multilevel linear regression. Structural equation modelling tested education, depressive symptoms and physical state as mediators. The relationship between childhood socioeconomic advantage and disadvantage and the rate of cognitive decline was assessed using linear mixed-effects models. Higher childhood SEP was associated with a higher level of cognitive performance to a greater extent in women (B = 0.122; 95% CI 0.092–0.151) than in men (B = 0.109; 95% CI 0.084–0.135). The strongest mediator was education. Childhood socioeconomic disadvantage was related to a higher rate of decline in delayed recall in both sexes, with a greater association in women. Strategies to prevent impaired late-life cognitive functioning, such as reducing childhood socioeconomic disadvantages and improving education, might have a greater benefit for women.Katrin WolfovaZsofia CsajbokAnna KagstromIngemar KåreholtPavla CermakovaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Katrin Wolfova Zsofia Csajbok Anna Kagstrom Ingemar Kåreholt Pavla Cermakova Role of sex in the association between childhood socioeconomic position and cognitive ageing in later life
description	Abstract We aimed to explore sex differences in the association of childhood socioeconomic position (SEP) with the level of cognitive performance and the rate of cognitive decline. We studied 84,059 individuals (55% women; mean age 64 years) from the Survey on Health, Ageing and Retirement in Europe. Sex differences in the association of childhood SEP (household characteristics at age 10) with the level of cognitive performance (verbal fluency, immediate recall, delayed recall) were analysed using multilevel linear regression. Structural equation modelling tested education, depressive symptoms and physical state as mediators. The relationship between childhood socioeconomic advantage and disadvantage and the rate of cognitive decline was assessed using linear mixed-effects models. Higher childhood SEP was associated with a higher level of cognitive performance to a greater extent in women (B = 0.122; 95% CI 0.092–0.151) than in men (B = 0.109; 95% CI 0.084–0.135). The strongest mediator was education. Childhood socioeconomic disadvantage was related to a higher rate of decline in delayed recall in both sexes, with a greater association in women. Strategies to prevent impaired late-life cognitive functioning, such as reducing childhood socioeconomic disadvantages and improving education, might have a greater benefit for women.
format	article
author	Katrin Wolfova Zsofia Csajbok Anna Kagstrom Ingemar Kåreholt Pavla Cermakova
author_facet	Katrin Wolfova Zsofia Csajbok Anna Kagstrom Ingemar Kåreholt Pavla Cermakova
author_sort	Katrin Wolfova
title	Role of sex in the association between childhood socioeconomic position and cognitive ageing in later life
title_short	Role of sex in the association between childhood socioeconomic position and cognitive ageing in later life
title_full	Role of sex in the association between childhood socioeconomic position and cognitive ageing in later life
title_fullStr	Role of sex in the association between childhood socioeconomic position and cognitive ageing in later life
title_full_unstemmed	Role of sex in the association between childhood socioeconomic position and cognitive ageing in later life
title_sort	role of sex in the association between childhood socioeconomic position and cognitive ageing in later life
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/769092ecd8eb4874b288a60fae17192e
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Role of sex in the association between childhood socioeconomic position and cognitive ageing in later life

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