Ocular angiostrongyliasis in Thailand: a retrospective analysis over two decades

Suthasinee Sinawat,1 Thawinee Trisakul,1 Stephanie Choi,2 Michael Morley,2 Supat Sinawat,3 Yosanan Yospaiboon11KKU Eye Center, Department of Ophthalmology, Khon Kaen University, Khon Kaen, Thailand; 2Harvard Medical School, Boston, MA, USA; 3Department of Physiology, Khon Kaen University, Khon Kaen,...

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Autores principales:	Sinawat S, Trisakul T, Choi S, Morley M, Yospaiboon Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Angiostrongylus canthnensis intraocular parasite raw food ocular angiostrongyliasis. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/7691d18194b3408cb29272072a73e3c5
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spelling	oai:doaj.org-article:7691d18194b3408cb29272072a73e3c52021-12-02T01:03:47ZOcular angiostrongyliasis in Thailand: a retrospective analysis over two decades1177-5483https://doaj.org/article/7691d18194b3408cb29272072a73e3c52019-06-01T00:00:00Zhttps://www.dovepress.com/ocular-angiostrongyliasis-in-thailand-a-retrospective-analysis-over-tw-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Suthasinee Sinawat,1 Thawinee Trisakul,1 Stephanie Choi,2 Michael Morley,2 Supat Sinawat,3 Yosanan Yospaiboon11KKU Eye Center, Department of Ophthalmology, Khon Kaen University, Khon Kaen, Thailand; 2Harvard Medical School, Boston, MA, USA; 3Department of Physiology, Khon Kaen University, Khon Kaen, ThailandPurpose: To elucidate the clinical manifestations, management, and visual outcomes of patients with ocular angiostrongyliasis.Methods: This was a single-center retrospective study of patients with ocular angiostrongyliasis presenting between 1995 and 2017 at Srinagarind Hospital, Khon Kaen, Thailand. Cases were found based on a search of diagnostic codes. A total of 18 patients were diagnosed through identification of the Angiostrongylus cantonensis parasite within the eye. Medical records and ocular photography were reviewed.Results: There were 18 cases, with a mean age of 40.7±14.2 years. All patients had a history of raw food ingestion, such as snails. Most of the patients presented with blurred vision: 13 cases (72.22%) had best-corrected visual acuity of 2/60 or worse. Only one living larva was detected in each case. The size of larvae varied widely from 2.6–12.6 mm in length. Larvae were commonly detected in the vitreous cavity. Although multiple treatment modalities were used, including focal laser, surgery, antihelminthic drugs, and steroid treatment, the majority of cases (70.6%) did not have visual improvement.Conclusion: Focal laser is recommended to eradicate subretinal angiostrongyliasis, while laser treatment prior to surgical removal is recommended to eliminate intracameral and intravitreal angiostrongyliasis. Pulse methylprednisolone therapy may be beneficial in cases of acute optic neuritis. The visual prognosis mainly depends on ocular pathology and parasitic migration pathway.Keywords: Angiostrongylus canthnensis, intraocular parasite, raw food, ocular angiostrongyliasisSinawat STrisakul TChoi SMorley MSinawat SYospaiboon YYospaiboon YDove Medical PressarticleAngiostrongylus canthnensisintraocular parasiteraw foodocular angiostrongyliasis.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 1027-1031 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Angiostrongylus canthnensis intraocular parasite raw food ocular angiostrongyliasis. Ophthalmology RE1-994
spellingShingle	Angiostrongylus canthnensis intraocular parasite raw food ocular angiostrongyliasis. Ophthalmology RE1-994 Sinawat S Trisakul T Choi S Morley M Sinawat S Yospaiboon Y Yospaiboon Y Ocular angiostrongyliasis in Thailand: a retrospective analysis over two decades
description	Suthasinee Sinawat,1 Thawinee Trisakul,1 Stephanie Choi,2 Michael Morley,2 Supat Sinawat,3 Yosanan Yospaiboon11KKU Eye Center, Department of Ophthalmology, Khon Kaen University, Khon Kaen, Thailand; 2Harvard Medical School, Boston, MA, USA; 3Department of Physiology, Khon Kaen University, Khon Kaen, ThailandPurpose: To elucidate the clinical manifestations, management, and visual outcomes of patients with ocular angiostrongyliasis.Methods: This was a single-center retrospective study of patients with ocular angiostrongyliasis presenting between 1995 and 2017 at Srinagarind Hospital, Khon Kaen, Thailand. Cases were found based on a search of diagnostic codes. A total of 18 patients were diagnosed through identification of the Angiostrongylus cantonensis parasite within the eye. Medical records and ocular photography were reviewed.Results: There were 18 cases, with a mean age of 40.7±14.2 years. All patients had a history of raw food ingestion, such as snails. Most of the patients presented with blurred vision: 13 cases (72.22%) had best-corrected visual acuity of 2/60 or worse. Only one living larva was detected in each case. The size of larvae varied widely from 2.6–12.6 mm in length. Larvae were commonly detected in the vitreous cavity. Although multiple treatment modalities were used, including focal laser, surgery, antihelminthic drugs, and steroid treatment, the majority of cases (70.6%) did not have visual improvement.Conclusion: Focal laser is recommended to eradicate subretinal angiostrongyliasis, while laser treatment prior to surgical removal is recommended to eliminate intracameral and intravitreal angiostrongyliasis. Pulse methylprednisolone therapy may be beneficial in cases of acute optic neuritis. The visual prognosis mainly depends on ocular pathology and parasitic migration pathway.Keywords: Angiostrongylus canthnensis, intraocular parasite, raw food, ocular angiostrongyliasis
format	article
author	Sinawat S Trisakul T Choi S Morley M Sinawat S Yospaiboon Y Yospaiboon Y
author_facet	Sinawat S Trisakul T Choi S Morley M Sinawat S Yospaiboon Y Yospaiboon Y
author_sort	Sinawat S
title	Ocular angiostrongyliasis in Thailand: a retrospective analysis over two decades
title_short	Ocular angiostrongyliasis in Thailand: a retrospective analysis over two decades
title_full	Ocular angiostrongyliasis in Thailand: a retrospective analysis over two decades
title_fullStr	Ocular angiostrongyliasis in Thailand: a retrospective analysis over two decades
title_full_unstemmed	Ocular angiostrongyliasis in Thailand: a retrospective analysis over two decades
title_sort	ocular angiostrongyliasis in thailand: a retrospective analysis over two decades
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/7691d18194b3408cb29272072a73e3c5
work_keys_str_mv	AT sinawats ocularangiostrongyliasisinthailandaretrospectiveanalysisovertwodecades AT trisakult ocularangiostrongyliasisinthailandaretrospectiveanalysisovertwodecades AT chois ocularangiostrongyliasisinthailandaretrospectiveanalysisovertwodecades AT morleym ocularangiostrongyliasisinthailandaretrospectiveanalysisovertwodecades AT sinawats ocularangiostrongyliasisinthailandaretrospectiveanalysisovertwodecades AT yospaiboony ocularangiostrongyliasisinthailandaretrospectiveanalysisovertwodecades AT yospaiboony ocularangiostrongyliasisinthailandaretrospectiveanalysisovertwodecades
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Ocular angiostrongyliasis in Thailand: a retrospective analysis over two decades

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