Autophagy initiation by ULK complex assembly on ER tubulovesicular regions marked by ATG9 vesicles

The ULK1 complex is required during autophagosome nucleation, but where autophagic membranes initiate is unknown. Here the authors use super-resolution microscopy to propose that autophagosomes originate from tubulovesicular structures in the ER that align with ATG9 vesicles and recruit ULK1.

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Autores principales:	Eleftherios Karanasios, Simon A. Walker, Hanneke Okkenhaug, Maria Manifava, Eric Hummel, Hans Zimmermann, Qashif Ahmed, Marie-Charlotte Domart, Lucy Collinson, Nicholas T. Ktistakis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7693d72d52b9480299cc6dfc72d56712
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spelling	oai:doaj.org-article:7693d72d52b9480299cc6dfc72d567122021-12-02T16:57:18ZAutophagy initiation by ULK complex assembly on ER tubulovesicular regions marked by ATG9 vesicles10.1038/ncomms124202041-1723https://doaj.org/article/7693d72d52b9480299cc6dfc72d567122016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12420https://doaj.org/toc/2041-1723The ULK1 complex is required during autophagosome nucleation, but where autophagic membranes initiate is unknown. Here the authors use super-resolution microscopy to propose that autophagosomes originate from tubulovesicular structures in the ER that align with ATG9 vesicles and recruit ULK1.Eleftherios KaranasiosSimon A. WalkerHanneke OkkenhaugMaria ManifavaEric HummelHans ZimmermannQashif AhmedMarie-Charlotte DomartLucy CollinsonNicholas T. KtistakisNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eleftherios Karanasios Simon A. Walker Hanneke Okkenhaug Maria Manifava Eric Hummel Hans Zimmermann Qashif Ahmed Marie-Charlotte Domart Lucy Collinson Nicholas T. Ktistakis Autophagy initiation by ULK complex assembly on ER tubulovesicular regions marked by ATG9 vesicles
description	The ULK1 complex is required during autophagosome nucleation, but where autophagic membranes initiate is unknown. Here the authors use super-resolution microscopy to propose that autophagosomes originate from tubulovesicular structures in the ER that align with ATG9 vesicles and recruit ULK1.
format	article
author	Eleftherios Karanasios Simon A. Walker Hanneke Okkenhaug Maria Manifava Eric Hummel Hans Zimmermann Qashif Ahmed Marie-Charlotte Domart Lucy Collinson Nicholas T. Ktistakis
author_facet	Eleftherios Karanasios Simon A. Walker Hanneke Okkenhaug Maria Manifava Eric Hummel Hans Zimmermann Qashif Ahmed Marie-Charlotte Domart Lucy Collinson Nicholas T. Ktistakis
author_sort	Eleftherios Karanasios
title	Autophagy initiation by ULK complex assembly on ER tubulovesicular regions marked by ATG9 vesicles
title_short	Autophagy initiation by ULK complex assembly on ER tubulovesicular regions marked by ATG9 vesicles
title_full	Autophagy initiation by ULK complex assembly on ER tubulovesicular regions marked by ATG9 vesicles
title_fullStr	Autophagy initiation by ULK complex assembly on ER tubulovesicular regions marked by ATG9 vesicles
title_full_unstemmed	Autophagy initiation by ULK complex assembly on ER tubulovesicular regions marked by ATG9 vesicles
title_sort	autophagy initiation by ulk complex assembly on er tubulovesicular regions marked by atg9 vesicles
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/7693d72d52b9480299cc6dfc72d56712
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Autophagy initiation by ULK complex assembly on ER tubulovesicular regions marked by ATG9 vesicles

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