Extracellular Matrix Hydrogels Originated from Different Organs Mediate Tissue-Specific Properties and Function
Porcine extracellular matrix (pECM)-derived hydrogels were introduced, in recent years, aiming to benefit the pECM’s microstructure and bioactivity, while controlling the biomaterial’s physical and mechanical properties. The use of pECM from different tissues, however, offers tissue-specific feature...
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2021
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oai:doaj.org-article:7695823c97144631a4d90ad811c238de2021-11-11T17:06:09ZExtracellular Matrix Hydrogels Originated from Different Organs Mediate Tissue-Specific Properties and Function10.3390/ijms2221116241422-00671661-6596https://doaj.org/article/7695823c97144631a4d90ad811c238de2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11624https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Porcine extracellular matrix (pECM)-derived hydrogels were introduced, in recent years, aiming to benefit the pECM’s microstructure and bioactivity, while controlling the biomaterial’s physical and mechanical properties. The use of pECM from different tissues, however, offers tissue-specific features that can better serve different applications. In this study, pECM hydrogels derived from cardiac, artery, pancreas, and adipose tissues were compared in terms of composition, structure, and mechanical properties. While major similarities were demonstrated between all the pECM hydrogels, their distinctive attributes were also identified, and their substantial effects on cell-ECM interactions were revealed. Furthermore, through comprehensive protein and gene expression analyses, we show, for the first time, that each pECM hydrogel supports the spontaneous differentiation of induced pluripotent stem cells towards the resident cells of its origin tissue. These findings imply that the origin of ECM should be carefully considered when designing a biomedical platform, to achieve a maximal bioactive impact.Tzila DavidovYael EfraimRotem HayamJacopo OieniLimor BaruchMarcelle MachlufMDPI AGarticleextracellular matrixtissue-specifichiPSCECM hydrogelBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11624, p 11624 (2021) |
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DOAJ |
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DOAJ |
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EN |
| topic |
extracellular matrix tissue-specific hiPSC ECM hydrogel Biology (General) QH301-705.5 Chemistry QD1-999 |
| spellingShingle |
extracellular matrix tissue-specific hiPSC ECM hydrogel Biology (General) QH301-705.5 Chemistry QD1-999 Tzila Davidov Yael Efraim Rotem Hayam Jacopo Oieni Limor Baruch Marcelle Machluf Extracellular Matrix Hydrogels Originated from Different Organs Mediate Tissue-Specific Properties and Function |
| description |
Porcine extracellular matrix (pECM)-derived hydrogels were introduced, in recent years, aiming to benefit the pECM’s microstructure and bioactivity, while controlling the biomaterial’s physical and mechanical properties. The use of pECM from different tissues, however, offers tissue-specific features that can better serve different applications. In this study, pECM hydrogels derived from cardiac, artery, pancreas, and adipose tissues were compared in terms of composition, structure, and mechanical properties. While major similarities were demonstrated between all the pECM hydrogels, their distinctive attributes were also identified, and their substantial effects on cell-ECM interactions were revealed. Furthermore, through comprehensive protein and gene expression analyses, we show, for the first time, that each pECM hydrogel supports the spontaneous differentiation of induced pluripotent stem cells towards the resident cells of its origin tissue. These findings imply that the origin of ECM should be carefully considered when designing a biomedical platform, to achieve a maximal bioactive impact. |
| format |
article |
| author |
Tzila Davidov Yael Efraim Rotem Hayam Jacopo Oieni Limor Baruch Marcelle Machluf |
| author_facet |
Tzila Davidov Yael Efraim Rotem Hayam Jacopo Oieni Limor Baruch Marcelle Machluf |
| author_sort |
Tzila Davidov |
| title |
Extracellular Matrix Hydrogels Originated from Different Organs Mediate Tissue-Specific Properties and Function |
| title_short |
Extracellular Matrix Hydrogels Originated from Different Organs Mediate Tissue-Specific Properties and Function |
| title_full |
Extracellular Matrix Hydrogels Originated from Different Organs Mediate Tissue-Specific Properties and Function |
| title_fullStr |
Extracellular Matrix Hydrogels Originated from Different Organs Mediate Tissue-Specific Properties and Function |
| title_full_unstemmed |
Extracellular Matrix Hydrogels Originated from Different Organs Mediate Tissue-Specific Properties and Function |
| title_sort |
extracellular matrix hydrogels originated from different organs mediate tissue-specific properties and function |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/7695823c97144631a4d90ad811c238de |
| work_keys_str_mv |
AT tziladavidov extracellularmatrixhydrogelsoriginatedfromdifferentorgansmediatetissuespecificpropertiesandfunction AT yaelefraim extracellularmatrixhydrogelsoriginatedfromdifferentorgansmediatetissuespecificpropertiesandfunction AT rotemhayam extracellularmatrixhydrogelsoriginatedfromdifferentorgansmediatetissuespecificpropertiesandfunction AT jacopooieni extracellularmatrixhydrogelsoriginatedfromdifferentorgansmediatetissuespecificpropertiesandfunction AT limorbaruch extracellularmatrixhydrogelsoriginatedfromdifferentorgansmediatetissuespecificpropertiesandfunction AT marcellemachluf extracellularmatrixhydrogelsoriginatedfromdifferentorgansmediatetissuespecificpropertiesandfunction |
| _version_ |
1718432184594857984 |