The relationship of early recurrence of atrial fibrillation and the 3-month integrity of the ablation lesion set

Abstract Early recurrence of atrial fibrillation (ERAF) after catheter-ablation (CA) can be a transient phenomenon due to inflammation, or a harbinger of late AF recurrence due to CA lesion (re)conduction. We studied the relationship between ERAF and the 3-month CA lesions integrity. Forty one conse...

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Autores principales:	Nebojša Mujović, Milan Marinković, Nebojša Marković, Vera Vučićević, Gregory Y. H. Lip, T. Jared Bunch, Tatjana S. Potpara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7699f128f6794494b2f002fb39045535
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spelling	oai:doaj.org-article:7699f128f6794494b2f002fb390455352021-12-02T15:08:26ZThe relationship of early recurrence of atrial fibrillation and the 3-month integrity of the ablation lesion set10.1038/s41598-018-28072-y2045-2322https://doaj.org/article/7699f128f6794494b2f002fb390455352018-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-28072-yhttps://doaj.org/toc/2045-2322Abstract Early recurrence of atrial fibrillation (ERAF) after catheter-ablation (CA) can be a transient phenomenon due to inflammation, or a harbinger of late AF recurrence due to CA lesion (re)conduction. We studied the relationship between ERAF and the 3-month CA lesions integrity. Forty one consecutive AF patients who underwent a pulmonary vein isolation (PVI), roof line (RL) and mitral isthmus line (MIL) CA were enrolled. At 3 months all patients underwent invasive assessment of the lesion set integrity irrespective of ERAF. The PVI, RL and MIL ablation was successful in 100.0%, 95.1% and 82.9% patients, respectively. At the 3-month remapping, a gap in PVI-lesion(s), RL or MIL was identified in 61.0%, 31.7% and 36.6% patients, respectively. Patients with (n = 17, 41.5%) compared to those without ERAF (n = 24) had a significantly higher rate of any PV-reconnection (88.2% vs. 41.7%), the right PV(s)-reconnection (82.5% vs. 29.2%) and the RL gap (52.9% vs. 16.7%), as well as a higher number of reconnected right PVI-segments, all p < 0.05. On multivariate analysis, only the number of reconnected right PVI-segments was associated with ERAF (OR 4.26, p = 0.004). The ERAF following PVI + RL + MIL ablation was significantly related to 3-month PV-reconnections and the presence of RL gaps.Nebojša MujovićMilan MarinkovićNebojša MarkovićVera VučićevićGregory Y. H. LipT. Jared BunchTatjana S. PotparaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nebojša Mujović Milan Marinković Nebojša Marković Vera Vučićević Gregory Y. H. Lip T. Jared Bunch Tatjana S. Potpara The relationship of early recurrence of atrial fibrillation and the 3-month integrity of the ablation lesion set
description	Abstract Early recurrence of atrial fibrillation (ERAF) after catheter-ablation (CA) can be a transient phenomenon due to inflammation, or a harbinger of late AF recurrence due to CA lesion (re)conduction. We studied the relationship between ERAF and the 3-month CA lesions integrity. Forty one consecutive AF patients who underwent a pulmonary vein isolation (PVI), roof line (RL) and mitral isthmus line (MIL) CA were enrolled. At 3 months all patients underwent invasive assessment of the lesion set integrity irrespective of ERAF. The PVI, RL and MIL ablation was successful in 100.0%, 95.1% and 82.9% patients, respectively. At the 3-month remapping, a gap in PVI-lesion(s), RL or MIL was identified in 61.0%, 31.7% and 36.6% patients, respectively. Patients with (n = 17, 41.5%) compared to those without ERAF (n = 24) had a significantly higher rate of any PV-reconnection (88.2% vs. 41.7%), the right PV(s)-reconnection (82.5% vs. 29.2%) and the RL gap (52.9% vs. 16.7%), as well as a higher number of reconnected right PVI-segments, all p < 0.05. On multivariate analysis, only the number of reconnected right PVI-segments was associated with ERAF (OR 4.26, p = 0.004). The ERAF following PVI + RL + MIL ablation was significantly related to 3-month PV-reconnections and the presence of RL gaps.
format	article
author	Nebojša Mujović Milan Marinković Nebojša Marković Vera Vučićević Gregory Y. H. Lip T. Jared Bunch Tatjana S. Potpara
author_facet	Nebojša Mujović Milan Marinković Nebojša Marković Vera Vučićević Gregory Y. H. Lip T. Jared Bunch Tatjana S. Potpara
author_sort	Nebojša Mujović
title	The relationship of early recurrence of atrial fibrillation and the 3-month integrity of the ablation lesion set
title_short	The relationship of early recurrence of atrial fibrillation and the 3-month integrity of the ablation lesion set
title_full	The relationship of early recurrence of atrial fibrillation and the 3-month integrity of the ablation lesion set
title_fullStr	The relationship of early recurrence of atrial fibrillation and the 3-month integrity of the ablation lesion set
title_full_unstemmed	The relationship of early recurrence of atrial fibrillation and the 3-month integrity of the ablation lesion set
title_sort	relationship of early recurrence of atrial fibrillation and the 3-month integrity of the ablation lesion set
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7699f128f6794494b2f002fb39045535
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The relationship of early recurrence of atrial fibrillation and the 3-month integrity of the ablation lesion set

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