The New Age of Virus Discovery: Genomic Analysis of a Novel Human Betacoronavirus Isolated from a Fatal Case of Pneumonia

ABSTRACT A new human betacoronavirus in lineage c, tentatively called HCoV-EMC, was isolated from a patient from the Kingdom of Saudi Arabia who died from acute severe pneumonia and renal failure. The viral RNA has been detected in eight additional cases. Sequencing and bioinformatic analysis of the...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kathryn V. Holmes, Samuel R. Dominguez
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2013
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/7699f27c7df34c15be9b47076830324e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7699f27c7df34c15be9b47076830324e
record_format	dspace
spelling	oai:doaj.org-article:7699f27c7df34c15be9b47076830324e2021-11-15T15:40:25ZThe New Age of Virus Discovery: Genomic Analysis of a Novel Human Betacoronavirus Isolated from a Fatal Case of Pneumonia10.1128/mBio.00548-122150-7511https://doaj.org/article/7699f27c7df34c15be9b47076830324e2013-03-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00548-12https://doaj.org/toc/2150-7511ABSTRACT A new human betacoronavirus in lineage c, tentatively called HCoV-EMC, was isolated from a patient from the Kingdom of Saudi Arabia who died from acute severe pneumonia and renal failure. The viral RNA has been detected in eight additional cases. Sequencing and bioinformatic analysis of the viral genomic RNA showed that it is a novel virus not previously detected in any other species and that its closest relatives are two Asian bat coronaviruses. HCoV-EMC may represent a sporadic spillover to humans from an unknown animal reservoir. In a recent article, van Boheemen et al. demonstrated how state-of-the-art sequencing technology and bioinformatic analysis can quickly provide critical insight into the viral genome sequence, phylogeny, replication strategy, and potential drug and vaccine targets and generate tools to evaluate the possible epidemic risk associated with this novel human virus.Kathryn V. HolmesSamuel R. DominguezAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 4, Iss 1 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Kathryn V. Holmes Samuel R. Dominguez The New Age of Virus Discovery: Genomic Analysis of a Novel Human Betacoronavirus Isolated from a Fatal Case of Pneumonia
description	ABSTRACT A new human betacoronavirus in lineage c, tentatively called HCoV-EMC, was isolated from a patient from the Kingdom of Saudi Arabia who died from acute severe pneumonia and renal failure. The viral RNA has been detected in eight additional cases. Sequencing and bioinformatic analysis of the viral genomic RNA showed that it is a novel virus not previously detected in any other species and that its closest relatives are two Asian bat coronaviruses. HCoV-EMC may represent a sporadic spillover to humans from an unknown animal reservoir. In a recent article, van Boheemen et al. demonstrated how state-of-the-art sequencing technology and bioinformatic analysis can quickly provide critical insight into the viral genome sequence, phylogeny, replication strategy, and potential drug and vaccine targets and generate tools to evaluate the possible epidemic risk associated with this novel human virus.
format	article
author	Kathryn V. Holmes Samuel R. Dominguez
author_facet	Kathryn V. Holmes Samuel R. Dominguez
author_sort	Kathryn V. Holmes
title	The New Age of Virus Discovery: Genomic Analysis of a Novel Human Betacoronavirus Isolated from a Fatal Case of Pneumonia
title_short	The New Age of Virus Discovery: Genomic Analysis of a Novel Human Betacoronavirus Isolated from a Fatal Case of Pneumonia
title_full	The New Age of Virus Discovery: Genomic Analysis of a Novel Human Betacoronavirus Isolated from a Fatal Case of Pneumonia
title_fullStr	The New Age of Virus Discovery: Genomic Analysis of a Novel Human Betacoronavirus Isolated from a Fatal Case of Pneumonia
title_full_unstemmed	The New Age of Virus Discovery: Genomic Analysis of a Novel Human Betacoronavirus Isolated from a Fatal Case of Pneumonia
title_sort	new age of virus discovery: genomic analysis of a novel human betacoronavirus isolated from a fatal case of pneumonia
publisher	American Society for Microbiology
publishDate	2013
url	https://doaj.org/article/7699f27c7df34c15be9b47076830324e
work_keys_str_mv	AT kathrynvholmes thenewageofvirusdiscoverygenomicanalysisofanovelhumanbetacoronavirusisolatedfromafatalcaseofpneumonia AT samuelrdominguez thenewageofvirusdiscoverygenomicanalysisofanovelhumanbetacoronavirusisolatedfromafatalcaseofpneumonia AT kathrynvholmes newageofvirusdiscoverygenomicanalysisofanovelhumanbetacoronavirusisolatedfromafatalcaseofpneumonia AT samuelrdominguez newageofvirusdiscoverygenomicanalysisofanovelhumanbetacoronavirusisolatedfromafatalcaseofpneumonia
_version_	1718427772068560896

The New Age of Virus Discovery: Genomic Analysis of a Novel Human Betacoronavirus Isolated from a Fatal Case of Pneumonia

Ejemplares similares