TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling

Tetraspanin 8 (TSPAN8) has been implicated in a number of different tumours, but the underlying mechanisms remain unclear. Here, in breast cancer the authors highlight a role for TSPAN8 in promoting tumorigenesis through the activation of Hedgehog signalling.

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Autores principales:	Rongxuan Zhu, Olivier Gires, Liqun Zhu, Jun Liu, Junjian Li, Hao Yang, Gaoda Ju, Jing Huang, Weiyu Ge, Yi Chen, Zhimin Lu, Hongxia Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/769dc01c63c3489aa39054afc3be9b52
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spelling	oai:doaj.org-article:769dc01c63c3489aa39054afc3be9b522021-12-02T17:32:09ZTSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling10.1038/s41467-019-10739-32041-1723https://doaj.org/article/769dc01c63c3489aa39054afc3be9b522019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10739-3https://doaj.org/toc/2041-1723Tetraspanin 8 (TSPAN8) has been implicated in a number of different tumours, but the underlying mechanisms remain unclear. Here, in breast cancer the authors highlight a role for TSPAN8 in promoting tumorigenesis through the activation of Hedgehog signalling.Rongxuan ZhuOlivier GiresLiqun ZhuJun LiuJunjian LiHao YangGaoda JuJing HuangWeiyu GeYi ChenZhimin LuHongxia WangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rongxuan Zhu Olivier Gires Liqun Zhu Jun Liu Junjian Li Hao Yang Gaoda Ju Jing Huang Weiyu Ge Yi Chen Zhimin Lu Hongxia Wang TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling
description	Tetraspanin 8 (TSPAN8) has been implicated in a number of different tumours, but the underlying mechanisms remain unclear. Here, in breast cancer the authors highlight a role for TSPAN8 in promoting tumorigenesis through the activation of Hedgehog signalling.
format	article
author	Rongxuan Zhu Olivier Gires Liqun Zhu Jun Liu Junjian Li Hao Yang Gaoda Ju Jing Huang Weiyu Ge Yi Chen Zhimin Lu Hongxia Wang
author_facet	Rongxuan Zhu Olivier Gires Liqun Zhu Jun Liu Junjian Li Hao Yang Gaoda Ju Jing Huang Weiyu Ge Yi Chen Zhimin Lu Hongxia Wang
author_sort	Rongxuan Zhu
title	TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling
title_short	TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling
title_full	TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling
title_fullStr	TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling
title_full_unstemmed	TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling
title_sort	tspan8 promotes cancer cell stemness via activation of sonic hedgehog signaling
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/769dc01c63c3489aa39054afc3be9b52
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TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling

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