Significance of the results of genome-wide association studies for primary prevention of type 2 diabetes mellitus and its complications. Personalised approach

The method of Genome-Wide Association Studies (GWAS) steadily becomes the basis for searching for candidate genes of monogenic and multifactorial diseases, including type 1 and 2 diabetes mellitus, coronary heart disease, obesity, vascular diseases, and others. To date, approximately 40 loci associa...

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Autores principales:	Ivan Ivanovich Dedov, Olga Mikhailovna Smirnova, Irina Vladimirovna Kononenko
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2014
Materias:	diabetes mellitus cardiovascular diseases genome-wide association studies risk of development prediction Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/76a2399ee8764c37ba55656791232ce4
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spelling	oai:doaj.org-article:76a2399ee8764c37ba55656791232ce42021-11-14T09:00:19ZSignificance of the results of genome-wide association studies for primary prevention of type 2 diabetes mellitus and its complications. Personalised approach2072-03512072-037810.14341/DM2014210-19https://doaj.org/article/76a2399ee8764c37ba55656791232ce42014-07-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6495https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378The method of Genome-Wide Association Studies (GWAS) steadily becomes the basis for searching for candidate genes of monogenic and multifactorial diseases, including type 1 and 2 diabetes mellitus, coronary heart disease, obesity, vascular diseases, and others. To date, approximately 40 loci associated with type 2 diabetes mellitus (T2DM) have been identified and genetic predisposition factors for cardiovascular diseases have been determined. In some cases, the GWAS results not only enable understanding of the pathophysiologic basis for diseases, but also may give rise to new drugs. However, the question naturally arises about the possibility of implementing the accumulated knowledge to predict the development of diseases, including T2DM and its vascular complications. This review summarises the literature data on the possibilities to use the GWAS results to calculate the risk of developing diabetes and cardiovascular diseases. Determination of the individual genetic risk will allow for the primary prevention of diseases and will apparently be the basis of personalised predictive medicine in the near future.Ivan Ivanovich DedovOlga Mikhailovna SmirnovaIrina Vladimirovna KononenkoEndocrinology Research Centrearticlediabetes mellituscardiovascular diseasesgenome-wide association studiesrisk of developmentpredictionNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 17, Iss 2, Pp 10-19 (2014)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus cardiovascular diseases genome-wide association studies risk of development prediction Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus cardiovascular diseases genome-wide association studies risk of development prediction Nutritional diseases. Deficiency diseases RC620-627 Ivan Ivanovich Dedov Olga Mikhailovna Smirnova Irina Vladimirovna Kononenko Significance of the results of genome-wide association studies for primary prevention of type 2 diabetes mellitus and its complications. Personalised approach
description	The method of Genome-Wide Association Studies (GWAS) steadily becomes the basis for searching for candidate genes of monogenic and multifactorial diseases, including type 1 and 2 diabetes mellitus, coronary heart disease, obesity, vascular diseases, and others. To date, approximately 40 loci associated with type 2 diabetes mellitus (T2DM) have been identified and genetic predisposition factors for cardiovascular diseases have been determined. In some cases, the GWAS results not only enable understanding of the pathophysiologic basis for diseases, but also may give rise to new drugs. However, the question naturally arises about the possibility of implementing the accumulated knowledge to predict the development of diseases, including T2DM and its vascular complications. This review summarises the literature data on the possibilities to use the GWAS results to calculate the risk of developing diabetes and cardiovascular diseases. Determination of the individual genetic risk will allow for the primary prevention of diseases and will apparently be the basis of personalised predictive medicine in the near future.
format	article
author	Ivan Ivanovich Dedov Olga Mikhailovna Smirnova Irina Vladimirovna Kononenko
author_facet	Ivan Ivanovich Dedov Olga Mikhailovna Smirnova Irina Vladimirovna Kononenko
author_sort	Ivan Ivanovich Dedov
title	Significance of the results of genome-wide association studies for primary prevention of type 2 diabetes mellitus and its complications. Personalised approach
title_short	Significance of the results of genome-wide association studies for primary prevention of type 2 diabetes mellitus and its complications. Personalised approach
title_full	Significance of the results of genome-wide association studies for primary prevention of type 2 diabetes mellitus and its complications. Personalised approach
title_fullStr	Significance of the results of genome-wide association studies for primary prevention of type 2 diabetes mellitus and its complications. Personalised approach
title_full_unstemmed	Significance of the results of genome-wide association studies for primary prevention of type 2 diabetes mellitus and its complications. Personalised approach
title_sort	significance of the results of genome-wide association studies for primary prevention of type 2 diabetes mellitus and its complications. personalised approach
publisher	Endocrinology Research Centre
publishDate	2014
url	https://doaj.org/article/76a2399ee8764c37ba55656791232ce4
work_keys_str_mv	AT ivanivanovichdedov significanceoftheresultsofgenomewideassociationstudiesforprimarypreventionoftype2diabetesmellitusanditscomplicationspersonalisedapproach AT olgamikhailovnasmirnova significanceoftheresultsofgenomewideassociationstudiesforprimarypreventionoftype2diabetesmellitusanditscomplicationspersonalisedapproach AT irinavladimirovnakononenko significanceoftheresultsofgenomewideassociationstudiesforprimarypreventionoftype2diabetesmellitusanditscomplicationspersonalisedapproach
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Significance of the results of genome-wide association studies for primary prevention of type 2 diabetes mellitus and its complications. Personalised approach

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