Winner-takes-all resource competition redirects cascading cell fate transitions

Synthetic gene circuits may not function as expected due to the resource competition between modules. Here the authors build cascading bistable switches to achieve two successive cell fate transitions but found a ‘winner-takes-all’ behaviour, which is overcome by a division of labour strategy.

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Autores principales:	Rong Zhang, Hanah Goetz, Juan Melendez-Alvarez, Jiao Li, Tian Ding, Xiao Wang, Xiao-Jun Tian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/76aa8ef4d58146ff93fb7b0a98d1fc43
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spelling	oai:doaj.org-article:76aa8ef4d58146ff93fb7b0a98d1fc432021-12-02T14:10:56ZWinner-takes-all resource competition redirects cascading cell fate transitions10.1038/s41467-021-21125-32041-1723https://doaj.org/article/76aa8ef4d58146ff93fb7b0a98d1fc432021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21125-3https://doaj.org/toc/2041-1723Synthetic gene circuits may not function as expected due to the resource competition between modules. Here the authors build cascading bistable switches to achieve two successive cell fate transitions but found a ‘winner-takes-all’ behaviour, which is overcome by a division of labour strategy.Rong ZhangHanah GoetzJuan Melendez-AlvarezJiao LiTian DingXiao WangXiao-Jun TianNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rong Zhang Hanah Goetz Juan Melendez-Alvarez Jiao Li Tian Ding Xiao Wang Xiao-Jun Tian Winner-takes-all resource competition redirects cascading cell fate transitions
description	Synthetic gene circuits may not function as expected due to the resource competition between modules. Here the authors build cascading bistable switches to achieve two successive cell fate transitions but found a ‘winner-takes-all’ behaviour, which is overcome by a division of labour strategy.
format	article
author	Rong Zhang Hanah Goetz Juan Melendez-Alvarez Jiao Li Tian Ding Xiao Wang Xiao-Jun Tian
author_facet	Rong Zhang Hanah Goetz Juan Melendez-Alvarez Jiao Li Tian Ding Xiao Wang Xiao-Jun Tian
author_sort	Rong Zhang
title	Winner-takes-all resource competition redirects cascading cell fate transitions
title_short	Winner-takes-all resource competition redirects cascading cell fate transitions
title_full	Winner-takes-all resource competition redirects cascading cell fate transitions
title_fullStr	Winner-takes-all resource competition redirects cascading cell fate transitions
title_full_unstemmed	Winner-takes-all resource competition redirects cascading cell fate transitions
title_sort	winner-takes-all resource competition redirects cascading cell fate transitions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/76aa8ef4d58146ff93fb7b0a98d1fc43
work_keys_str_mv	AT rongzhang winnertakesallresourcecompetitionredirectscascadingcellfatetransitions AT hanahgoetz winnertakesallresourcecompetitionredirectscascadingcellfatetransitions AT juanmelendezalvarez winnertakesallresourcecompetitionredirectscascadingcellfatetransitions AT jiaoli winnertakesallresourcecompetitionredirectscascadingcellfatetransitions AT tianding winnertakesallresourcecompetitionredirectscascadingcellfatetransitions AT xiaowang winnertakesallresourcecompetitionredirectscascadingcellfatetransitions AT xiaojuntian winnertakesallresourcecompetitionredirectscascadingcellfatetransitions
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Winner-takes-all resource competition redirects cascading cell fate transitions

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