Phenotypic changes of HER2-positive breast cancer during and after dual HER2 blockade
HER2-enriched breast cancers within the HER2-positive subtype are addicted to the HER2 pathway. Here, the authors analyse gene expression before, during, and after treatment with anti-HER2-based therapies in the phase II PAMELA clinical trial, finding phenotypic changes induced by treatment.
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2020
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oai:doaj.org-article:76ae9021acef4670a550a57d2950a3032021-12-02T13:24:34ZPhenotypic changes of HER2-positive breast cancer during and after dual HER2 blockade10.1038/s41467-019-14111-32041-1723https://doaj.org/article/76ae9021acef4670a550a57d2950a3032020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14111-3https://doaj.org/toc/2041-1723HER2-enriched breast cancers within the HER2-positive subtype are addicted to the HER2 pathway. Here, the authors analyse gene expression before, during, and after treatment with anti-HER2-based therapies in the phase II PAMELA clinical trial, finding phenotypic changes induced by treatment.Fara Brasó-MaristanyGaia GriguoloTomás PascualLaia ParéPaolo NuciforoAntonio Llombart-CussacBegoña BermejoMafalda OliveiraSerafín MoralesNoelia MartínezMaria VidalBarbara AdamoOlga MartínezSonia PernasRafael LópezMontserrat MuñozNúria ChicPatricia GalvánIsabel GarauLuis MansoJesús AlarcónEduardo MartínezSara GregorioRoger R. GomisPatricia VillagrasaJavier CortésEva CiruelosAleix PratNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020) |
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Science Q Fara Brasó-Maristany Gaia Griguolo Tomás Pascual Laia Paré Paolo Nuciforo Antonio Llombart-Cussac Begoña Bermejo Mafalda Oliveira Serafín Morales Noelia Martínez Maria Vidal Barbara Adamo Olga Martínez Sonia Pernas Rafael López Montserrat Muñoz Núria Chic Patricia Galván Isabel Garau Luis Manso Jesús Alarcón Eduardo Martínez Sara Gregorio Roger R. Gomis Patricia Villagrasa Javier Cortés Eva Ciruelos Aleix Prat Phenotypic changes of HER2-positive breast cancer during and after dual HER2 blockade |
| description |
HER2-enriched breast cancers within the HER2-positive subtype are addicted to the HER2 pathway. Here, the authors analyse gene expression before, during, and after treatment with anti-HER2-based therapies in the phase II PAMELA clinical trial, finding phenotypic changes induced by treatment. |
| format |
article |
| author |
Fara Brasó-Maristany Gaia Griguolo Tomás Pascual Laia Paré Paolo Nuciforo Antonio Llombart-Cussac Begoña Bermejo Mafalda Oliveira Serafín Morales Noelia Martínez Maria Vidal Barbara Adamo Olga Martínez Sonia Pernas Rafael López Montserrat Muñoz Núria Chic Patricia Galván Isabel Garau Luis Manso Jesús Alarcón Eduardo Martínez Sara Gregorio Roger R. Gomis Patricia Villagrasa Javier Cortés Eva Ciruelos Aleix Prat |
| author_facet |
Fara Brasó-Maristany Gaia Griguolo Tomás Pascual Laia Paré Paolo Nuciforo Antonio Llombart-Cussac Begoña Bermejo Mafalda Oliveira Serafín Morales Noelia Martínez Maria Vidal Barbara Adamo Olga Martínez Sonia Pernas Rafael López Montserrat Muñoz Núria Chic Patricia Galván Isabel Garau Luis Manso Jesús Alarcón Eduardo Martínez Sara Gregorio Roger R. Gomis Patricia Villagrasa Javier Cortés Eva Ciruelos Aleix Prat |
| author_sort |
Fara Brasó-Maristany |
| title |
Phenotypic changes of HER2-positive breast cancer during and after dual HER2 blockade |
| title_short |
Phenotypic changes of HER2-positive breast cancer during and after dual HER2 blockade |
| title_full |
Phenotypic changes of HER2-positive breast cancer during and after dual HER2 blockade |
| title_fullStr |
Phenotypic changes of HER2-positive breast cancer during and after dual HER2 blockade |
| title_full_unstemmed |
Phenotypic changes of HER2-positive breast cancer during and after dual HER2 blockade |
| title_sort |
phenotypic changes of her2-positive breast cancer during and after dual her2 blockade |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/76ae9021acef4670a550a57d2950a303 |
| work_keys_str_mv |
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