Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish

Inflammatory responses must be induced and resolved timely to serve protection from pathogens without inducing excessive tissue damage. Here the authors use live imaging in zebrafish to show that the intracellular trafficking of two chemokine receptors, Cxcr1 and Cxcr2, is differentially regulated o...

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Autores principales:	Caroline Coombs, Antonios Georgantzoglou, Hazel A. Walker, Julian Patt, Nicole Merten, Hugo Poplimont, Elisabeth M. Busch-Nentwich, Sarah Williams, Christina Kotsi, Evi Kostenis, Milka Sarris
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/76af9888082741848d9ffe0c719d5118
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spelling	oai:doaj.org-article:76af9888082741848d9ffe0c719d51182021-12-02T17:01:52ZChemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish10.1038/s41467-019-13107-32041-1723https://doaj.org/article/76af9888082741848d9ffe0c719d51182019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13107-3https://doaj.org/toc/2041-1723Inflammatory responses must be induced and resolved timely to serve protection from pathogens without inducing excessive tissue damage. Here the authors use live imaging in zebrafish to show that the intracellular trafficking of two chemokine receptors, Cxcr1 and Cxcr2, is differentially regulated on activated neutrophils to control their clustering and dispersal, respectively.Caroline CoombsAntonios GeorgantzoglouHazel A. WalkerJulian PattNicole MertenHugo PoplimontElisabeth M. Busch-NentwichSarah WilliamsChristina KotsiEvi KostenisMilka SarrisNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Caroline Coombs Antonios Georgantzoglou Hazel A. Walker Julian Patt Nicole Merten Hugo Poplimont Elisabeth M. Busch-Nentwich Sarah Williams Christina Kotsi Evi Kostenis Milka Sarris Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish
description	Inflammatory responses must be induced and resolved timely to serve protection from pathogens without inducing excessive tissue damage. Here the authors use live imaging in zebrafish to show that the intracellular trafficking of two chemokine receptors, Cxcr1 and Cxcr2, is differentially regulated on activated neutrophils to control their clustering and dispersal, respectively.
format	article
author	Caroline Coombs Antonios Georgantzoglou Hazel A. Walker Julian Patt Nicole Merten Hugo Poplimont Elisabeth M. Busch-Nentwich Sarah Williams Christina Kotsi Evi Kostenis Milka Sarris
author_facet	Caroline Coombs Antonios Georgantzoglou Hazel A. Walker Julian Patt Nicole Merten Hugo Poplimont Elisabeth M. Busch-Nentwich Sarah Williams Christina Kotsi Evi Kostenis Milka Sarris
author_sort	Caroline Coombs
title	Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish
title_short	Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish
title_full	Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish
title_fullStr	Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish
title_full_unstemmed	Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish
title_sort	chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/76af9888082741848d9ffe0c719d5118
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Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish

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