Effects of Intratympanic Injection of Isosorbide on the Vestibular Function of Animal Models of Endolymphatic Hydrops

Objectives The aims of this study were to investigate the effects of intratympanic injections of isosorbide on vestibular function in animal models of endolymphatic hydrops and to find a new treatment option for the acute onset of vertigo in Ménière disease (MD). Methods Seventy male guinea pigs rec...

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Autores principales:	Minbum Kim, So Yeon Yoon, Hansol Hong, Hyun Jun Hong
Formato:	article
Lenguaje:	EN
Publicado:	Korean Society of Otorhinolaryngology-Head and Neck Surgery 2021
Materias:	isosorbide endolymphatic hydrops meniere disease Medicine R Otorhinolaryngology RF1-547
Acceso en línea:	https://doaj.org/article/76b184360faa48e6a18a37b8f37e0a9c
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spelling	oai:doaj.org-article:76b184360faa48e6a18a37b8f37e0a9c2021-11-18T02:29:22ZEffects of Intratympanic Injection of Isosorbide on the Vestibular Function of Animal Models of Endolymphatic Hydrops1976-87102005-072010.21053/ceo.2019.02040https://doaj.org/article/76b184360faa48e6a18a37b8f37e0a9c2021-11-01T00:00:00Zhttp://www.e-ceo.org/upload/pdf/ceo-2019-02040.pdfhttps://doaj.org/toc/1976-8710https://doaj.org/toc/2005-0720Objectives The aims of this study were to investigate the effects of intratympanic injections of isosorbide on vestibular function in animal models of endolymphatic hydrops and to find a new treatment option for the acute onset of vertigo in Ménière disease (MD). Methods Seventy male guinea pigs received intratympanic injection of isosorbide (IT-ISB). The animals were divided into three study groups: control, a chronic hydrops model, and an acute hydrops model. Intracochlear drug concentrations were measured using high-performance liquid chromatography. Vestibular function was analyzed using an animal rotator test with bidirectional sinusoidal harmonic acceleration before and after IT-ISB administration. Histological changes were also investigated. Results ISB successfully permeated the perilymph through the round window membrane (RWM) at all three concentrations (25%, 50%, and 100%). In the chronic hydrops model, while IT-ISB histologically induced a reduction of endolymphatic hydrops, vestibular function was unchanged. In the acute hydrops model, no endolymphatic hydrops was histologically observed, and vestibular symmetry was also preserved after IT-ISB. Conclusion ISB passed through the RWM into the perilymphatic space even at lower concentrations. IT-ISB histologically reduced hydrops in the chronic model and preserved symmetrical vestibular function in the acute model. IT-ISB could be a treatment candidate for acute attacks of vertigo in MD.Minbum KimSo Yeon YoonHansol HongHyun Jun HongKorean Society of Otorhinolaryngology-Head and Neck Surgeryarticleisosorbideendolymphatic hydropsmeniere diseaseMedicineROtorhinolaryngologyRF1-547ENClinical and Experimental Otorhinolaryngology, Vol 14, Iss 4, Pp 367-373 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	isosorbide endolymphatic hydrops meniere disease Medicine R Otorhinolaryngology RF1-547
spellingShingle	isosorbide endolymphatic hydrops meniere disease Medicine R Otorhinolaryngology RF1-547 Minbum Kim So Yeon Yoon Hansol Hong Hyun Jun Hong Effects of Intratympanic Injection of Isosorbide on the Vestibular Function of Animal Models of Endolymphatic Hydrops
description	Objectives The aims of this study were to investigate the effects of intratympanic injections of isosorbide on vestibular function in animal models of endolymphatic hydrops and to find a new treatment option for the acute onset of vertigo in Ménière disease (MD). Methods Seventy male guinea pigs received intratympanic injection of isosorbide (IT-ISB). The animals were divided into three study groups: control, a chronic hydrops model, and an acute hydrops model. Intracochlear drug concentrations were measured using high-performance liquid chromatography. Vestibular function was analyzed using an animal rotator test with bidirectional sinusoidal harmonic acceleration before and after IT-ISB administration. Histological changes were also investigated. Results ISB successfully permeated the perilymph through the round window membrane (RWM) at all three concentrations (25%, 50%, and 100%). In the chronic hydrops model, while IT-ISB histologically induced a reduction of endolymphatic hydrops, vestibular function was unchanged. In the acute hydrops model, no endolymphatic hydrops was histologically observed, and vestibular symmetry was also preserved after IT-ISB. Conclusion ISB passed through the RWM into the perilymphatic space even at lower concentrations. IT-ISB histologically reduced hydrops in the chronic model and preserved symmetrical vestibular function in the acute model. IT-ISB could be a treatment candidate for acute attacks of vertigo in MD.
format	article
author	Minbum Kim So Yeon Yoon Hansol Hong Hyun Jun Hong
author_facet	Minbum Kim So Yeon Yoon Hansol Hong Hyun Jun Hong
author_sort	Minbum Kim
title	Effects of Intratympanic Injection of Isosorbide on the Vestibular Function of Animal Models of Endolymphatic Hydrops
title_short	Effects of Intratympanic Injection of Isosorbide on the Vestibular Function of Animal Models of Endolymphatic Hydrops
title_full	Effects of Intratympanic Injection of Isosorbide on the Vestibular Function of Animal Models of Endolymphatic Hydrops
title_fullStr	Effects of Intratympanic Injection of Isosorbide on the Vestibular Function of Animal Models of Endolymphatic Hydrops
title_full_unstemmed	Effects of Intratympanic Injection of Isosorbide on the Vestibular Function of Animal Models of Endolymphatic Hydrops
title_sort	effects of intratympanic injection of isosorbide on the vestibular function of animal models of endolymphatic hydrops
publisher	Korean Society of Otorhinolaryngology-Head and Neck Surgery
publishDate	2021
url	https://doaj.org/article/76b184360faa48e6a18a37b8f37e0a9c
work_keys_str_mv	AT minbumkim effectsofintratympanicinjectionofisosorbideonthevestibularfunctionofanimalmodelsofendolymphatichydrops AT soyeonyoon effectsofintratympanicinjectionofisosorbideonthevestibularfunctionofanimalmodelsofendolymphatichydrops AT hansolhong effectsofintratympanicinjectionofisosorbideonthevestibularfunctionofanimalmodelsofendolymphatichydrops AT hyunjunhong effectsofintratympanicinjectionofisosorbideonthevestibularfunctionofanimalmodelsofendolymphatichydrops
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Effects of Intratympanic Injection of Isosorbide on the Vestibular Function of Animal Models of Endolymphatic Hydrops

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