Targeted Treatment of Colon Cancer with Aptamer-Guided Albumin Nanoparticles Loaded with Docetaxel

Zhen Yu, Xundou Li, Jinhong Duan, Xian-Da Yang Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of ChinaCorrespondence: Xian-Da Yang Email ayangmd@hotmail.comPurpose: Chemotherapy of colon cancer nee...

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Autores principales:	Yu Z, Li X, Duan J, Yang X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	aptamer nanoparticles colon cancer targeted drug delivery system Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/76b3b21d98d84209a3ce2ed3e35b696b
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spelling	oai:doaj.org-article:76b3b21d98d84209a3ce2ed3e35b696b2021-12-02T12:53:31ZTargeted Treatment of Colon Cancer with Aptamer-Guided Albumin Nanoparticles Loaded with Docetaxel1178-2013https://doaj.org/article/76b3b21d98d84209a3ce2ed3e35b696b2020-09-01T00:00:00Zhttps://www.dovepress.com/targeted-treatment-of-colon-cancer-with-aptamer-guided-albumin-nanopar-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Zhen Yu, Xundou Li, Jinhong Duan, Xian-Da Yang Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of ChinaCorrespondence: Xian-Da Yang Email ayangmd@hotmail.comPurpose: Chemotherapy of colon cancer needs improvement to mitigate the severe adverse effects (AEs) associated with the cytotoxic drugs. The aim of this study is to develop a novel targeted drug delivery system (TDDS) with practical application potential for colon cancer treatment.Methods: The TDDS was built by loading docetaxel (DTX) in albumin nanoparticles (NPs) that were functionalized with nucleolin-targeted aptamers (AS1411).Results: The TDDS (Apt-NPs-DTX) had an average size of 62 nm and was negatively charged with a zeta potential of − 31.2 mV. DTX was released from the albumin NP with a typical sustained release profile. Aptamer-guided NPs were preferentially ingested by nucleolin-expressing CT26 colon cancer cells vs the control cells. In vitro cytotoxicity study showed that Apt-NPs-DTX significantly enhanced the killing of CT26 colon cancer cells. Importantly, compared with non-targeted drug delivery, Apt-NPs-DTX treatment significantly improved antitumor efficacy and prolonged the survival of CT26-bearing mice, without raising systemic toxicity.Conclusion: The results suggest that Apt-NPs-DTX has potential in the targeted treatment of colon cancer.Keywords: aptamer, nanoparticles, colon cancer, targeted drug delivery systemYu ZLi XDuan JYang XDove Medical Pressarticleaptamernanoparticlescolon cancertargeted drug delivery systemMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 6737-6748 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	aptamer nanoparticles colon cancer targeted drug delivery system Medicine (General) R5-920
spellingShingle	aptamer nanoparticles colon cancer targeted drug delivery system Medicine (General) R5-920 Yu Z Li X Duan J Yang X Targeted Treatment of Colon Cancer with Aptamer-Guided Albumin Nanoparticles Loaded with Docetaxel
description	Zhen Yu, Xundou Li, Jinhong Duan, Xian-Da Yang Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of ChinaCorrespondence: Xian-Da Yang Email ayangmd@hotmail.comPurpose: Chemotherapy of colon cancer needs improvement to mitigate the severe adverse effects (AEs) associated with the cytotoxic drugs. The aim of this study is to develop a novel targeted drug delivery system (TDDS) with practical application potential for colon cancer treatment.Methods: The TDDS was built by loading docetaxel (DTX) in albumin nanoparticles (NPs) that were functionalized with nucleolin-targeted aptamers (AS1411).Results: The TDDS (Apt-NPs-DTX) had an average size of 62 nm and was negatively charged with a zeta potential of − 31.2 mV. DTX was released from the albumin NP with a typical sustained release profile. Aptamer-guided NPs were preferentially ingested by nucleolin-expressing CT26 colon cancer cells vs the control cells. In vitro cytotoxicity study showed that Apt-NPs-DTX significantly enhanced the killing of CT26 colon cancer cells. Importantly, compared with non-targeted drug delivery, Apt-NPs-DTX treatment significantly improved antitumor efficacy and prolonged the survival of CT26-bearing mice, without raising systemic toxicity.Conclusion: The results suggest that Apt-NPs-DTX has potential in the targeted treatment of colon cancer.Keywords: aptamer, nanoparticles, colon cancer, targeted drug delivery system
format	article
author	Yu Z Li X Duan J Yang X
author_facet	Yu Z Li X Duan J Yang X
author_sort	Yu Z
title	Targeted Treatment of Colon Cancer with Aptamer-Guided Albumin Nanoparticles Loaded with Docetaxel
title_short	Targeted Treatment of Colon Cancer with Aptamer-Guided Albumin Nanoparticles Loaded with Docetaxel
title_full	Targeted Treatment of Colon Cancer with Aptamer-Guided Albumin Nanoparticles Loaded with Docetaxel
title_fullStr	Targeted Treatment of Colon Cancer with Aptamer-Guided Albumin Nanoparticles Loaded with Docetaxel
title_full_unstemmed	Targeted Treatment of Colon Cancer with Aptamer-Guided Albumin Nanoparticles Loaded with Docetaxel
title_sort	targeted treatment of colon cancer with aptamer-guided albumin nanoparticles loaded with docetaxel
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/76b3b21d98d84209a3ce2ed3e35b696b
work_keys_str_mv	AT yuz targetedtreatmentofcoloncancerwithaptamerguidedalbuminnanoparticlesloadedwithdocetaxel AT lix targetedtreatmentofcoloncancerwithaptamerguidedalbuminnanoparticlesloadedwithdocetaxel AT duanj targetedtreatmentofcoloncancerwithaptamerguidedalbuminnanoparticlesloadedwithdocetaxel AT yangx targetedtreatmentofcoloncancerwithaptamerguidedalbuminnanoparticlesloadedwithdocetaxel
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Targeted Treatment of Colon Cancer with Aptamer-Guided Albumin Nanoparticles Loaded with Docetaxel

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