A systematic review and meta-analysis of geographic differences in comorbidities and associated severity and mortality among individuals with COVID-19

Abstract Several comorbidities have been shown to be associated with coronavirus disease 2019 (COVID-19) related severity and mortality. However, considerable variation in the prevalence estimates of comorbidities and their effects on COVID-19 morbidity and mortality have been observed in prior stud...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Bhaskar Thakur, Pallavi Dubey, Joseph Benitez, Joshua P. Torres, Sireesha Reddy, Navkiran Shokar, Koko Aung, Debabrata Mukherjee, Alok Kumar Dwivedi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/76b73e51a68e407d854a30dbcd84dc49
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:76b73e51a68e407d854a30dbcd84dc49
record_format	dspace
spelling	oai:doaj.org-article:76b73e51a68e407d854a30dbcd84dc492021-12-02T17:32:58ZA systematic review and meta-analysis of geographic differences in comorbidities and associated severity and mortality among individuals with COVID-1910.1038/s41598-021-88130-w2045-2322https://doaj.org/article/76b73e51a68e407d854a30dbcd84dc492021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88130-whttps://doaj.org/toc/2045-2322Abstract Several comorbidities have been shown to be associated with coronavirus disease 2019 (COVID-19) related severity and mortality. However, considerable variation in the prevalence estimates of comorbidities and their effects on COVID-19 morbidity and mortality have been observed in prior studies. This systematic review and meta-analysis aimed to determine geographical, age, and gender related differences in the prevalence of comorbidities and associated severity and mortality rates among COVID-19 patients. We conducted a search using PubMed, Scopus, and EMBASE to include all COVID-19 studies published between January 1st, 2020 to July 24th, 2020 reporting comorbidities with severity or mortality. We included studies reporting the confirmed diagnosis of COVID-19 on human patients that also provided information on comorbidities or disease outcomes. We used DerSimonian and Laird random effects method for calculating estimates. Of 120 studies with 125,446 patients, the most prevalent comorbidity was hypertension (32%), obesity (25%), diabetes (18%), and cardiovascular disease (16%) while chronic kidney or other renal diseases (51%, 44%), cerebrovascular accident (43%, 44%), and cardiovascular disease (44%, 40%) patients had more COVID-19 severity and mortality respectively. Considerable variation in the prevalence of comorbidities and associated disease severity and mortality in different geographic regions was observed. The highest mortality was observed in studies with Latin American and European patients with any medical condition, mostly older adults (≥ 65 years), and predominantly male patients. Although the US studies observed the highest prevalence of comorbidities in COVID-19 patients, the severity of COVID-19 among each comorbid condition was highest in Asian studies whereas the mortality was highest in the European and Latin American countries. Risk stratification and effective control strategies for the COVID-19 should be done according to comorbidities, age, and gender differences specific to geographical location.Bhaskar ThakurPallavi DubeyJoseph BenitezJoshua P. TorresSireesha ReddyNavkiran ShokarKoko AungDebabrata MukherjeeAlok Kumar DwivediNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bhaskar Thakur Pallavi Dubey Joseph Benitez Joshua P. Torres Sireesha Reddy Navkiran Shokar Koko Aung Debabrata Mukherjee Alok Kumar Dwivedi A systematic review and meta-analysis of geographic differences in comorbidities and associated severity and mortality among individuals with COVID-19
description	Abstract Several comorbidities have been shown to be associated with coronavirus disease 2019 (COVID-19) related severity and mortality. However, considerable variation in the prevalence estimates of comorbidities and their effects on COVID-19 morbidity and mortality have been observed in prior studies. This systematic review and meta-analysis aimed to determine geographical, age, and gender related differences in the prevalence of comorbidities and associated severity and mortality rates among COVID-19 patients. We conducted a search using PubMed, Scopus, and EMBASE to include all COVID-19 studies published between January 1st, 2020 to July 24th, 2020 reporting comorbidities with severity or mortality. We included studies reporting the confirmed diagnosis of COVID-19 on human patients that also provided information on comorbidities or disease outcomes. We used DerSimonian and Laird random effects method for calculating estimates. Of 120 studies with 125,446 patients, the most prevalent comorbidity was hypertension (32%), obesity (25%), diabetes (18%), and cardiovascular disease (16%) while chronic kidney or other renal diseases (51%, 44%), cerebrovascular accident (43%, 44%), and cardiovascular disease (44%, 40%) patients had more COVID-19 severity and mortality respectively. Considerable variation in the prevalence of comorbidities and associated disease severity and mortality in different geographic regions was observed. The highest mortality was observed in studies with Latin American and European patients with any medical condition, mostly older adults (≥ 65 years), and predominantly male patients. Although the US studies observed the highest prevalence of comorbidities in COVID-19 patients, the severity of COVID-19 among each comorbid condition was highest in Asian studies whereas the mortality was highest in the European and Latin American countries. Risk stratification and effective control strategies for the COVID-19 should be done according to comorbidities, age, and gender differences specific to geographical location.
format	article
author	Bhaskar Thakur Pallavi Dubey Joseph Benitez Joshua P. Torres Sireesha Reddy Navkiran Shokar Koko Aung Debabrata Mukherjee Alok Kumar Dwivedi
author_facet	Bhaskar Thakur Pallavi Dubey Joseph Benitez Joshua P. Torres Sireesha Reddy Navkiran Shokar Koko Aung Debabrata Mukherjee Alok Kumar Dwivedi
author_sort	Bhaskar Thakur
title	A systematic review and meta-analysis of geographic differences in comorbidities and associated severity and mortality among individuals with COVID-19
title_short	A systematic review and meta-analysis of geographic differences in comorbidities and associated severity and mortality among individuals with COVID-19
title_full	A systematic review and meta-analysis of geographic differences in comorbidities and associated severity and mortality among individuals with COVID-19
title_fullStr	A systematic review and meta-analysis of geographic differences in comorbidities and associated severity and mortality among individuals with COVID-19
title_full_unstemmed	A systematic review and meta-analysis of geographic differences in comorbidities and associated severity and mortality among individuals with COVID-19
title_sort	systematic review and meta-analysis of geographic differences in comorbidities and associated severity and mortality among individuals with covid-19
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/76b73e51a68e407d854a30dbcd84dc49
work_keys_str_mv	AT bhaskarthakur asystematicreviewandmetaanalysisofgeographicdifferencesincomorbiditiesandassociatedseverityandmortalityamongindividualswithcovid19 AT pallavidubey asystematicreviewandmetaanalysisofgeographicdifferencesincomorbiditiesandassociatedseverityandmortalityamongindividualswithcovid19 AT josephbenitez asystematicreviewandmetaanalysisofgeographicdifferencesincomorbiditiesandassociatedseverityandmortalityamongindividualswithcovid19 AT joshuaptorres asystematicreviewandmetaanalysisofgeographicdifferencesincomorbiditiesandassociatedseverityandmortalityamongindividualswithcovid19 AT sireeshareddy asystematicreviewandmetaanalysisofgeographicdifferencesincomorbiditiesandassociatedseverityandmortalityamongindividualswithcovid19 AT navkiranshokar asystematicreviewandmetaanalysisofgeographicdifferencesincomorbiditiesandassociatedseverityandmortalityamongindividualswithcovid19 AT kokoaung asystematicreviewandmetaanalysisofgeographicdifferencesincomorbiditiesandassociatedseverityandmortalityamongindividualswithcovid19 AT debabratamukherjee asystematicreviewandmetaanalysisofgeographicdifferencesincomorbiditiesandassociatedseverityandmortalityamongindividualswithcovid19 AT alokkumardwivedi asystematicreviewandmetaanalysisofgeographicdifferencesincomorbiditiesandassociatedseverityandmortalityamongindividualswithcovid19 AT bhaskarthakur systematicreviewandmetaanalysisofgeographicdifferencesincomorbiditiesandassociatedseverityandmortalityamongindividualswithcovid19 AT pallavidubey systematicreviewandmetaanalysisofgeographicdifferencesincomorbiditiesandassociatedseverityandmortalityamongindividualswithcovid19 AT josephbenitez systematicreviewandmetaanalysisofgeographicdifferencesincomorbiditiesandassociatedseverityandmortalityamongindividualswithcovid19 AT joshuaptorres systematicreviewandmetaanalysisofgeographicdifferencesincomorbiditiesandassociatedseverityandmortalityamongindividualswithcovid19 AT sireeshareddy systematicreviewandmetaanalysisofgeographicdifferencesincomorbiditiesandassociatedseverityandmortalityamongindividualswithcovid19 AT navkiranshokar systematicreviewandmetaanalysisofgeographicdifferencesincomorbiditiesandassociatedseverityandmortalityamongindividualswithcovid19 AT kokoaung systematicreviewandmetaanalysisofgeographicdifferencesincomorbiditiesandassociatedseverityandmortalityamongindividualswithcovid19 AT debabratamukherjee systematicreviewandmetaanalysisofgeographicdifferencesincomorbiditiesandassociatedseverityandmortalityamongindividualswithcovid19 AT alokkumardwivedi systematicreviewandmetaanalysisofgeographicdifferencesincomorbiditiesandassociatedseverityandmortalityamongindividualswithcovid19
_version_	1718380128666386432

A systematic review and meta-analysis of geographic differences in comorbidities and associated severity and mortality among individuals with COVID-19

Ejemplares similares