PROGRESSION VARIANTS OF CHRONIC SYSTEMIC INFLAMMATION

Abstract. Fourteen groups of patients have been investigated and divided into 2 classes. The first class included the following cohorts of patients: relatively healthy persons, age 18 to 55 yrs (n = 50); elderly persons 60 yrs old, as well as senior persons (n = 22); persons with chronic adnexitis,...

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Autores principales:	E. Y. Gusev, V. A. Chereshnev, J. A. Zhuravleva, L. V. Solomatina, T. E. Zubova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	stem cells side population flow cytometry hematopoiesis tumor Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/76b7a242ab5042eb9562132ef1386124
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spelling	oai:doaj.org-article:76b7a242ab5042eb9562132ef13861242021-11-18T08:03:39ZPROGRESSION VARIANTS OF CHRONIC SYSTEMIC INFLAMMATION1563-06252313-741X10.15789/1563-0625-2009-2-3-131-140https://doaj.org/article/76b7a242ab5042eb9562132ef13861242014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/270https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Fourteen groups of patients have been investigated and divided into 2 classes. The first class included the following cohorts of patients: relatively healthy persons, age 18 to 55 yrs (n = 50); elderly persons 60 yrs old, as well as senior persons (n = 22); persons with chronic adnexitis, women in their 1st trimester of pregnancy (n = 16); climacteric syndrome (n = 16); autoimmune thyroiditis (n = 29). The second class of patients included following cohorts: elderly persons with chronic cardiac insufficiency (CCI) II-III stage (n=49); valvular cardiac disease (rheumatism, n = 15); psoriatic arthritis (n = 12); reactive arthritis (n = 17); antiphospholipid syndrome, a sub-group in the 1st trimester of pregnancy (n = 5); systemic lupus erythematosus (n=49); decompensated atherosclerosis of femoral artery (n = 38); end-stage renal disease (n = 42). Plasma cytokines (TNFαα, IL-6, IL-8, IL-10), acute-phase C-reactive protein (CRP), cortisol, troponin I, myoglobin, D-dimers, interleukin-2 soluble receptor (IL-2sR), and eosinophil cationic protein (ECP) were determined in all the patients, by means of immune chemiluminescent technique (Immulite; Siemens Medical Solutions Diagnostics, USA). The integral indices of systemic inflammatory reaction (SIR) have been calculated, i.e., a Reactivity Coefficient (RC) and a Reactivity Level (RL). In the patients belonging to Class 1 cohorts, an absence of chronic systemic inflammation features was revealed, despite of some signs of systemic inflammatory response. Meanwhile, a majority of Class 2 patients have shown the signs of chronic systemic inflammation stage I to III.E. Y. GusevV. A. ChereshnevJ. A. ZhuravlevaL. V. SolomatinaT. E. ZubovaSPb RAACIarticlestem cellsside populationflow cytometryhematopoiesistumorImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 11, Iss 2-3, Pp 131-140 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	stem cells side population flow cytometry hematopoiesis tumor Immunologic diseases. Allergy RC581-607
spellingShingle	stem cells side population flow cytometry hematopoiesis tumor Immunologic diseases. Allergy RC581-607 E. Y. Gusev V. A. Chereshnev J. A. Zhuravleva L. V. Solomatina T. E. Zubova PROGRESSION VARIANTS OF CHRONIC SYSTEMIC INFLAMMATION
description	Abstract. Fourteen groups of patients have been investigated and divided into 2 classes. The first class included the following cohorts of patients: relatively healthy persons, age 18 to 55 yrs (n = 50); elderly persons 60 yrs old, as well as senior persons (n = 22); persons with chronic adnexitis, women in their 1st trimester of pregnancy (n = 16); climacteric syndrome (n = 16); autoimmune thyroiditis (n = 29). The second class of patients included following cohorts: elderly persons with chronic cardiac insufficiency (CCI) II-III stage (n=49); valvular cardiac disease (rheumatism, n = 15); psoriatic arthritis (n = 12); reactive arthritis (n = 17); antiphospholipid syndrome, a sub-group in the 1st trimester of pregnancy (n = 5); systemic lupus erythematosus (n=49); decompensated atherosclerosis of femoral artery (n = 38); end-stage renal disease (n = 42). Plasma cytokines (TNFαα, IL-6, IL-8, IL-10), acute-phase C-reactive protein (CRP), cortisol, troponin I, myoglobin, D-dimers, interleukin-2 soluble receptor (IL-2sR), and eosinophil cationic protein (ECP) were determined in all the patients, by means of immune chemiluminescent technique (Immulite; Siemens Medical Solutions Diagnostics, USA). The integral indices of systemic inflammatory reaction (SIR) have been calculated, i.e., a Reactivity Coefficient (RC) and a Reactivity Level (RL). In the patients belonging to Class 1 cohorts, an absence of chronic systemic inflammation features was revealed, despite of some signs of systemic inflammatory response. Meanwhile, a majority of Class 2 patients have shown the signs of chronic systemic inflammation stage I to III.
format	article
author	E. Y. Gusev V. A. Chereshnev J. A. Zhuravleva L. V. Solomatina T. E. Zubova
author_facet	E. Y. Gusev V. A. Chereshnev J. A. Zhuravleva L. V. Solomatina T. E. Zubova
author_sort	E. Y. Gusev
title	PROGRESSION VARIANTS OF CHRONIC SYSTEMIC INFLAMMATION
title_short	PROGRESSION VARIANTS OF CHRONIC SYSTEMIC INFLAMMATION
title_full	PROGRESSION VARIANTS OF CHRONIC SYSTEMIC INFLAMMATION
title_fullStr	PROGRESSION VARIANTS OF CHRONIC SYSTEMIC INFLAMMATION
title_full_unstemmed	PROGRESSION VARIANTS OF CHRONIC SYSTEMIC INFLAMMATION
title_sort	progression variants of chronic systemic inflammation
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/76b7a242ab5042eb9562132ef1386124
work_keys_str_mv	AT eygusev progressionvariantsofchronicsystemicinflammation AT vachereshnev progressionvariantsofchronicsystemicinflammation AT jazhuravleva progressionvariantsofchronicsystemicinflammation AT lvsolomatina progressionvariantsofchronicsystemicinflammation AT tezubova progressionvariantsofchronicsystemicinflammation
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PROGRESSION VARIANTS OF CHRONIC SYSTEMIC INFLAMMATION

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