An Exploration of Non-Coding RNAs in Extracellular Vesicles Delivered by Swine Anterior Pituitary

Extracellular vesicles are lipid bilayer-delimited particles carrying proteins, lipids, and small RNAs. Previous studies have demonstrated that they had regulatory functions both physiologically and pathologically. However, information remains inadequate on extracellular vesicles from the anterior p...

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Autores principales:	Jiali Xiong, Haojie Zhang, Bin Zeng, Jie Liu, Junyi Luo, Ting Chen, Jiajie Sun, Qianyun Xi, Yongliang Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	anterior pituitary extracellular vesicles miRNA lncRNA circRNA cross-talk Genetics QH426-470
Acceso en línea:	https://doaj.org/article/76b845802d2447f0985c154cf6b5d2a2
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spelling	oai:doaj.org-article:76b845802d2447f0985c154cf6b5d2a22021-12-01T13:57:07ZAn Exploration of Non-Coding RNAs in Extracellular Vesicles Delivered by Swine Anterior Pituitary1664-802110.3389/fgene.2021.772753https://doaj.org/article/76b845802d2447f0985c154cf6b5d2a22021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fgene.2021.772753/fullhttps://doaj.org/toc/1664-8021Extracellular vesicles are lipid bilayer-delimited particles carrying proteins, lipids, and small RNAs. Previous studies have demonstrated that they had regulatory functions both physiologically and pathologically. However, information remains inadequate on extracellular vesicles from the anterior pituitary, a key endocrine organ in animals and humans. In this study, we separated and identified extracellular vesicles from the anterior pituitary of the Duroc swine model. Total RNA was extracted and RNA-seq was performed, followed by a comprehensive analysis of miRNAs, lncRNAs, and circRNAs. Resultantly, we obtained 416 miRNAs, 16,232 lncRNAs, and 495 circRNAs. Furthermore, GO and KEGG enrichment analysis showed that the ncRNAs in extracellular vesicles may participate in regulating intracellular signal transduction, cellular component organization or biogenesis, small molecule binding, and transferase activity. The cross-talk between them also suggested that they may play an important role in the signaling process and biological regulation. This is the first report of ncRNA data in the anterior pituitary extracellular vesicles from the duroc swine breed, which is a fundamental resource for exploring detailed functions of extracellular vesicles from the anterior pituitary.Jiali XiongHaojie ZhangBin ZengJie LiuJunyi LuoTing ChenJiajie SunQianyun XiYongliang ZhangFrontiers Media S.A.articleanterior pituitary extracellular vesiclesmiRNAlncRNAcircRNAcross-talkGeneticsQH426-470ENFrontiers in Genetics, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anterior pituitary extracellular vesicles miRNA lncRNA circRNA cross-talk Genetics QH426-470
spellingShingle	anterior pituitary extracellular vesicles miRNA lncRNA circRNA cross-talk Genetics QH426-470 Jiali Xiong Haojie Zhang Bin Zeng Jie Liu Junyi Luo Ting Chen Jiajie Sun Qianyun Xi Yongliang Zhang An Exploration of Non-Coding RNAs in Extracellular Vesicles Delivered by Swine Anterior Pituitary
description	Extracellular vesicles are lipid bilayer-delimited particles carrying proteins, lipids, and small RNAs. Previous studies have demonstrated that they had regulatory functions both physiologically and pathologically. However, information remains inadequate on extracellular vesicles from the anterior pituitary, a key endocrine organ in animals and humans. In this study, we separated and identified extracellular vesicles from the anterior pituitary of the Duroc swine model. Total RNA was extracted and RNA-seq was performed, followed by a comprehensive analysis of miRNAs, lncRNAs, and circRNAs. Resultantly, we obtained 416 miRNAs, 16,232 lncRNAs, and 495 circRNAs. Furthermore, GO and KEGG enrichment analysis showed that the ncRNAs in extracellular vesicles may participate in regulating intracellular signal transduction, cellular component organization or biogenesis, small molecule binding, and transferase activity. The cross-talk between them also suggested that they may play an important role in the signaling process and biological regulation. This is the first report of ncRNA data in the anterior pituitary extracellular vesicles from the duroc swine breed, which is a fundamental resource for exploring detailed functions of extracellular vesicles from the anterior pituitary.
format	article
author	Jiali Xiong Haojie Zhang Bin Zeng Jie Liu Junyi Luo Ting Chen Jiajie Sun Qianyun Xi Yongliang Zhang
author_facet	Jiali Xiong Haojie Zhang Bin Zeng Jie Liu Junyi Luo Ting Chen Jiajie Sun Qianyun Xi Yongliang Zhang
author_sort	Jiali Xiong
title	An Exploration of Non-Coding RNAs in Extracellular Vesicles Delivered by Swine Anterior Pituitary
title_short	An Exploration of Non-Coding RNAs in Extracellular Vesicles Delivered by Swine Anterior Pituitary
title_full	An Exploration of Non-Coding RNAs in Extracellular Vesicles Delivered by Swine Anterior Pituitary
title_fullStr	An Exploration of Non-Coding RNAs in Extracellular Vesicles Delivered by Swine Anterior Pituitary
title_full_unstemmed	An Exploration of Non-Coding RNAs in Extracellular Vesicles Delivered by Swine Anterior Pituitary
title_sort	exploration of non-coding rnas in extracellular vesicles delivered by swine anterior pituitary
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/76b845802d2447f0985c154cf6b5d2a2
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An Exploration of Non-Coding RNAs in Extracellular Vesicles Delivered by Swine Anterior Pituitary

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