A TAD boundary is preserved upon deletion of the CTCF-rich Firre locus

Although CTCF binding has been implicated in the formation of topologically associated domains (TADs) the mechanisms folding the genome into TADs are not fully understood. Here the authors investigate the TAD boundary on lncRNA locus Firre, which has ~ 15 CTCF binding sites, and its organization.

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Autores principales:	A. Rasim Barutcu, Philipp G. Maass, Jordan P. Lewandowski, Catherine L. Weiner, John L. Rinn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/76bcea4638884d28801213481f652f01
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spelling	oai:doaj.org-article:76bcea4638884d28801213481f652f012021-12-02T14:40:55ZA TAD boundary is preserved upon deletion of the CTCF-rich Firre locus10.1038/s41467-018-03614-02041-1723https://doaj.org/article/76bcea4638884d28801213481f652f012018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03614-0https://doaj.org/toc/2041-1723Although CTCF binding has been implicated in the formation of topologically associated domains (TADs) the mechanisms folding the genome into TADs are not fully understood. Here the authors investigate the TAD boundary on lncRNA locus Firre, which has ~ 15 CTCF binding sites, and its organization.A. Rasim BarutcuPhilipp G. MaassJordan P. LewandowskiCatherine L. WeinerJohn L. RinnNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q A. Rasim Barutcu Philipp G. Maass Jordan P. Lewandowski Catherine L. Weiner John L. Rinn A TAD boundary is preserved upon deletion of the CTCF-rich Firre locus
description	Although CTCF binding has been implicated in the formation of topologically associated domains (TADs) the mechanisms folding the genome into TADs are not fully understood. Here the authors investigate the TAD boundary on lncRNA locus Firre, which has ~ 15 CTCF binding sites, and its organization.
format	article
author	A. Rasim Barutcu Philipp G. Maass Jordan P. Lewandowski Catherine L. Weiner John L. Rinn
author_facet	A. Rasim Barutcu Philipp G. Maass Jordan P. Lewandowski Catherine L. Weiner John L. Rinn
author_sort	A. Rasim Barutcu
title	A TAD boundary is preserved upon deletion of the CTCF-rich Firre locus
title_short	A TAD boundary is preserved upon deletion of the CTCF-rich Firre locus
title_full	A TAD boundary is preserved upon deletion of the CTCF-rich Firre locus
title_fullStr	A TAD boundary is preserved upon deletion of the CTCF-rich Firre locus
title_full_unstemmed	A TAD boundary is preserved upon deletion of the CTCF-rich Firre locus
title_sort	tad boundary is preserved upon deletion of the ctcf-rich firre locus
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/76bcea4638884d28801213481f652f01
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A TAD boundary is preserved upon deletion of the CTCF-rich Firre locus

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