Updates on Molecular and Biochemical Development and Progression of Prostate Cancer

Prostate cancer (PCa) represents the most commonly non-cutaneous diagnosed cancer in men worldwide and occupies a very wide area of preclinical and clinical research. Targeted therapy for any cancer depends on the understanding of the molecular bases and natural behaviour of the diseases. Despite th...

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Autores principales:	Omar Fahmy, Nabil A. Alhakamy, Waleed Y. Rizg, Alaa Bagalagel, Abdulmohsin J. Alamoudi, Hibah M. Aldawsari, Aiah M. Khateb, Basmah M. Eldakhakhny, Usama A. Fahmy, Wesam H. Abdulaal, Claudia G. Fresta, Giuseppe Caruso
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	prostate cancer progression and tumorigenesis biomarkers growth factors inflammation oxidative stress androgen deprivation therapy Medicine R
Acceso en línea:	https://doaj.org/article/76be595143794623a324bb2edae60e12
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spelling	oai:doaj.org-article:76be595143794623a324bb2edae60e122021-11-11T17:44:50ZUpdates on Molecular and Biochemical Development and Progression of Prostate Cancer10.3390/jcm102151272077-0383https://doaj.org/article/76be595143794623a324bb2edae60e122021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5127https://doaj.org/toc/2077-0383Prostate cancer (PCa) represents the most commonly non-cutaneous diagnosed cancer in men worldwide and occupies a very wide area of preclinical and clinical research. Targeted therapy for any cancer depends on the understanding of the molecular bases and natural behaviour of the diseases. Despite the well-known effect of androgen deprivation on PCa, many patients develop resistance either for antiandrogen therapy or other new treatment modalities such as checkpoint inhibitors and chemotherapy. Comprehensive understanding of the development of PCa as well as of the mechanisms underlying its progression is mandatory to maximise the benefit of the current approved medications or to guide the future research for targeted therapy of PCa. The aim of this review was to provide updates on the most recent mechanisms regarding the development and the progression of PCa. According to the current understanding, future treatment strategies should include more predictive genetic and biomarker analysis to assign different patients to the expected most appropriate and effective treatment.Omar FahmyNabil A. AlhakamyWaleed Y. RizgAlaa BagalagelAbdulmohsin J. AlamoudiHibah M. AldawsariAiah M. KhatebBasmah M. EldakhakhnyUsama A. FahmyWesam H. AbdulaalClaudia G. FrestaGiuseppe CarusoMDPI AGarticleprostate cancer progression and tumorigenesisbiomarkersgrowth factorsinflammationoxidative stressandrogen deprivation therapyMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5127, p 5127 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	prostate cancer progression and tumorigenesis biomarkers growth factors inflammation oxidative stress androgen deprivation therapy Medicine R
spellingShingle	prostate cancer progression and tumorigenesis biomarkers growth factors inflammation oxidative stress androgen deprivation therapy Medicine R Omar Fahmy Nabil A. Alhakamy Waleed Y. Rizg Alaa Bagalagel Abdulmohsin J. Alamoudi Hibah M. Aldawsari Aiah M. Khateb Basmah M. Eldakhakhny Usama A. Fahmy Wesam H. Abdulaal Claudia G. Fresta Giuseppe Caruso Updates on Molecular and Biochemical Development and Progression of Prostate Cancer
description	Prostate cancer (PCa) represents the most commonly non-cutaneous diagnosed cancer in men worldwide and occupies a very wide area of preclinical and clinical research. Targeted therapy for any cancer depends on the understanding of the molecular bases and natural behaviour of the diseases. Despite the well-known effect of androgen deprivation on PCa, many patients develop resistance either for antiandrogen therapy or other new treatment modalities such as checkpoint inhibitors and chemotherapy. Comprehensive understanding of the development of PCa as well as of the mechanisms underlying its progression is mandatory to maximise the benefit of the current approved medications or to guide the future research for targeted therapy of PCa. The aim of this review was to provide updates on the most recent mechanisms regarding the development and the progression of PCa. According to the current understanding, future treatment strategies should include more predictive genetic and biomarker analysis to assign different patients to the expected most appropriate and effective treatment.
format	article
author	Omar Fahmy Nabil A. Alhakamy Waleed Y. Rizg Alaa Bagalagel Abdulmohsin J. Alamoudi Hibah M. Aldawsari Aiah M. Khateb Basmah M. Eldakhakhny Usama A. Fahmy Wesam H. Abdulaal Claudia G. Fresta Giuseppe Caruso
author_facet	Omar Fahmy Nabil A. Alhakamy Waleed Y. Rizg Alaa Bagalagel Abdulmohsin J. Alamoudi Hibah M. Aldawsari Aiah M. Khateb Basmah M. Eldakhakhny Usama A. Fahmy Wesam H. Abdulaal Claudia G. Fresta Giuseppe Caruso
author_sort	Omar Fahmy
title	Updates on Molecular and Biochemical Development and Progression of Prostate Cancer
title_short	Updates on Molecular and Biochemical Development and Progression of Prostate Cancer
title_full	Updates on Molecular and Biochemical Development and Progression of Prostate Cancer
title_fullStr	Updates on Molecular and Biochemical Development and Progression of Prostate Cancer
title_full_unstemmed	Updates on Molecular and Biochemical Development and Progression of Prostate Cancer
title_sort	updates on molecular and biochemical development and progression of prostate cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/76be595143794623a324bb2edae60e12
work_keys_str_mv	AT omarfahmy updatesonmolecularandbiochemicaldevelopmentandprogressionofprostatecancer AT nabilaalhakamy updatesonmolecularandbiochemicaldevelopmentandprogressionofprostatecancer AT waleedyrizg updatesonmolecularandbiochemicaldevelopmentandprogressionofprostatecancer AT alaabagalagel updatesonmolecularandbiochemicaldevelopmentandprogressionofprostatecancer AT abdulmohsinjalamoudi updatesonmolecularandbiochemicaldevelopmentandprogressionofprostatecancer AT hibahmaldawsari updatesonmolecularandbiochemicaldevelopmentandprogressionofprostatecancer AT aiahmkhateb updatesonmolecularandbiochemicaldevelopmentandprogressionofprostatecancer AT basmahmeldakhakhny updatesonmolecularandbiochemicaldevelopmentandprogressionofprostatecancer AT usamaafahmy updatesonmolecularandbiochemicaldevelopmentandprogressionofprostatecancer AT wesamhabdulaal updatesonmolecularandbiochemicaldevelopmentandprogressionofprostatecancer AT claudiagfresta updatesonmolecularandbiochemicaldevelopmentandprogressionofprostatecancer AT giuseppecaruso updatesonmolecularandbiochemicaldevelopmentandprogressionofprostatecancer
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Updates on Molecular and Biochemical Development and Progression of Prostate Cancer

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