Laser speckle contrast imaging for intraoperative assessment of liver microcirculation: a clinical pilot study

Sam Eriksson,1,2,* Jan Nilsson,1,2,* Gert Lindell,1,2 Christian Sturesson1,2 1Department of Surgery, Clinical Sciences Lund, Lund University, 2Skåne University Hospital, Lund, Sweden  *These authors contributed equally to the study Background: Liver microcirculation can be affec...

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Autores principales:	Eriksson S, Nilsson J, Lindell G, Sturesson C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/76bfd5e95dee4c19afeec35c15e859e9
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spelling	oai:doaj.org-article:76bfd5e95dee4c19afeec35c15e859e92021-12-02T02:02:43ZLaser speckle contrast imaging for intraoperative assessment of liver microcirculation: a clinical pilot study1179-1470https://doaj.org/article/76bfd5e95dee4c19afeec35c15e859e92014-07-01T00:00:00Zhttp://www.dovepress.com/laser-speckle-contrast-imaging-for-intraoperative-assessment-of-liver--peer-reviewed-article-MDERhttps://doaj.org/toc/1179-1470 Sam Eriksson,1,2,* Jan Nilsson,1,2,* Gert Lindell,1,2 Christian Sturesson1,2 1Department of Surgery, Clinical Sciences Lund, Lund University, 2Skåne University Hospital, Lund, Sweden  *These authors contributed equally to the study Background: Liver microcirculation can be affected by a wide variety of causes relevant to liver transplantation and resectional surgery. Intraoperative assessment of the microcirculation could possibly predict postoperative outcome. The present pilot study introduces laser speckle contrast imaging (LSCI) as a new clinical method for assessing liver microcirculation. Methods: LSCI measurements of liver microcirculation were performed on ten patients undergoing liver resection. Measurements were made during apnea with and without liver blood inflow occlusion. Hepatic blood flow was assessed by subtracting zero inflow signal from the total signal. Zero inflow signal was obtained after hepatic artery and portal vein occlusion. Perfusion was expressed in laser speckle perfusion units, and intraindividual and interindividual variability in liver perfusion was investigated using the coefficient of variability. Results: Hepatic microcirculation measurements were successfully made in all patients resulting in analyzable speckle contrast images. Mean hepatic blood flow was 410±36 laser speckle perfusion units. Zero inflow signal amounted to 40%±4% of the total signal. Intraindividual and interindividual coefficients of variability in liver perfusion were 25% and 28%, respectively. Conclusion: Under the conditions of this pilot study, LSCI allows rapid noncontact measurements of hepatic blood perfusion over wide areas. More studies are needed on methods of handling movement artifacts. Keywords: liver surgery, blood perfusionEriksson SNilsson JLindell GSturesson CDove Medical PressarticleMedical technologyR855-855.5ENMedical Devices: Evidence and Research, Vol 2014, Iss default, Pp 257-261 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medical technology R855-855.5
spellingShingle	Medical technology R855-855.5 Eriksson S Nilsson J Lindell G Sturesson C Laser speckle contrast imaging for intraoperative assessment of liver microcirculation: a clinical pilot study
description	Sam Eriksson,1,2,* Jan Nilsson,1,2,* Gert Lindell,1,2 Christian Sturesson1,2 1Department of Surgery, Clinical Sciences Lund, Lund University, 2Skåne University Hospital, Lund, Sweden  *These authors contributed equally to the study Background: Liver microcirculation can be affected by a wide variety of causes relevant to liver transplantation and resectional surgery. Intraoperative assessment of the microcirculation could possibly predict postoperative outcome. The present pilot study introduces laser speckle contrast imaging (LSCI) as a new clinical method for assessing liver microcirculation. Methods: LSCI measurements of liver microcirculation were performed on ten patients undergoing liver resection. Measurements were made during apnea with and without liver blood inflow occlusion. Hepatic blood flow was assessed by subtracting zero inflow signal from the total signal. Zero inflow signal was obtained after hepatic artery and portal vein occlusion. Perfusion was expressed in laser speckle perfusion units, and intraindividual and interindividual variability in liver perfusion was investigated using the coefficient of variability. Results: Hepatic microcirculation measurements were successfully made in all patients resulting in analyzable speckle contrast images. Mean hepatic blood flow was 410±36 laser speckle perfusion units. Zero inflow signal amounted to 40%±4% of the total signal. Intraindividual and interindividual coefficients of variability in liver perfusion were 25% and 28%, respectively. Conclusion: Under the conditions of this pilot study, LSCI allows rapid noncontact measurements of hepatic blood perfusion over wide areas. More studies are needed on methods of handling movement artifacts. Keywords: liver surgery, blood perfusion
format	article
author	Eriksson S Nilsson J Lindell G Sturesson C
author_facet	Eriksson S Nilsson J Lindell G Sturesson C
author_sort	Eriksson S
title	Laser speckle contrast imaging for intraoperative assessment of liver microcirculation: a clinical pilot study
title_short	Laser speckle contrast imaging for intraoperative assessment of liver microcirculation: a clinical pilot study
title_full	Laser speckle contrast imaging for intraoperative assessment of liver microcirculation: a clinical pilot study
title_fullStr	Laser speckle contrast imaging for intraoperative assessment of liver microcirculation: a clinical pilot study
title_full_unstemmed	Laser speckle contrast imaging for intraoperative assessment of liver microcirculation: a clinical pilot study
title_sort	laser speckle contrast imaging for intraoperative assessment of liver microcirculation: a clinical pilot study
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/76bfd5e95dee4c19afeec35c15e859e9
work_keys_str_mv	AT erikssons laserspecklecontrastimagingforintraoperativeassessmentoflivermicrocirculationaclinicalpilotstudy AT nilssonj laserspecklecontrastimagingforintraoperativeassessmentoflivermicrocirculationaclinicalpilotstudy AT lindellg laserspecklecontrastimagingforintraoperativeassessmentoflivermicrocirculationaclinicalpilotstudy AT sturessonc laserspecklecontrastimagingforintraoperativeassessmentoflivermicrocirculationaclinicalpilotstudy
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Laser speckle contrast imaging for intraoperative assessment of liver microcirculation: a clinical pilot study

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