MiR-130a-3p suppresses colorectal cancer growth by targeting Wnt Family Member 1 (WNT1)

The microRNA miR-130a-3p (miR-130a-3p) has anti-tumor activity against numerous cancer types. Further, miR-130a-3p may target Wnt signaling, which is a critical pathway regulating tumorigenesis. Functions of miR-130a-3p in colorectal cancer (CRC) and contributions of Wnt1 pathway modulation, however...

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Autores principales:	Guang-Lin Song, Ming Xiao, Xiao-Ya Wan, Jun Deng, Jun-Da Ling, Ying-Guo Tian, Min Li, Jie Yin, Ren-Ying Zheng, Yi Tang, Gui-Yuan Liu
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	colorectal cancer mir-130a-3p tumor suppression wnt1 wnt signaling pathway Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/76c01e9aaeb240299368b8ff0ba91578
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spelling	oai:doaj.org-article:76c01e9aaeb240299368b8ff0ba915782021-11-17T14:21:59ZMiR-130a-3p suppresses colorectal cancer growth by targeting Wnt Family Member 1 (WNT1)2165-59792165-598710.1080/21655979.2021.1977556https://doaj.org/article/76c01e9aaeb240299368b8ff0ba915782021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.1977556https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987The microRNA miR-130a-3p (miR-130a-3p) has anti-tumor activity against numerous cancer types. Further, miR-130a-3p may target Wnt signaling, which is a critical pathway regulating tumorigenesis. Functions of miR-130a-3p in colorectal cancer (CRC) and contributions of Wnt1 pathway modulation, however, have not been examined, hence the exploration on these two aspects. In this study, in comparison with normal controls, both CRC tissue and multiple CRC cell lines showed downregulated miR-130a-3p. MiR-130a-3p overexpression contributed to a decrease in CRC cell proliferation. Additionally, its overexpression also caused reduced expression of WNT Family Member 1 (WNT1) and downstream WNT pathway factors c-myc and cyclin D1. Dual-luciferase assay revealed WNT1 as a direct target of miR-130a-3p, and further the inhibitory effect of miR-130a-3p on c-myc and cyclin D1 was proved to be reversed by overexpressed WNT1. Collectively, miR-130a-3p inhibits CRC growth by directly targeting WNT1, and miR-130a-3p and WNT1 pathway-associated factors are defined as potential targets for CRC treatment.Guang-Lin SongMing XiaoXiao-Ya WanJun DengJun-Da LingYing-Guo TianMin LiJie YinRen-Ying ZhengYi TangGui-Yuan LiuTaylor & Francis Grouparticlecolorectal cancermir-130a-3ptumor suppressionwnt1wnt signaling pathwayBiotechnologyTP248.13-248.65ENBioengineered, Vol 12, Iss 1, Pp 8407-8418 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	colorectal cancer mir-130a-3p tumor suppression wnt1 wnt signaling pathway Biotechnology TP248.13-248.65
spellingShingle	colorectal cancer mir-130a-3p tumor suppression wnt1 wnt signaling pathway Biotechnology TP248.13-248.65 Guang-Lin Song Ming Xiao Xiao-Ya Wan Jun Deng Jun-Da Ling Ying-Guo Tian Min Li Jie Yin Ren-Ying Zheng Yi Tang Gui-Yuan Liu MiR-130a-3p suppresses colorectal cancer growth by targeting Wnt Family Member 1 (WNT1)
description	The microRNA miR-130a-3p (miR-130a-3p) has anti-tumor activity against numerous cancer types. Further, miR-130a-3p may target Wnt signaling, which is a critical pathway regulating tumorigenesis. Functions of miR-130a-3p in colorectal cancer (CRC) and contributions of Wnt1 pathway modulation, however, have not been examined, hence the exploration on these two aspects. In this study, in comparison with normal controls, both CRC tissue and multiple CRC cell lines showed downregulated miR-130a-3p. MiR-130a-3p overexpression contributed to a decrease in CRC cell proliferation. Additionally, its overexpression also caused reduced expression of WNT Family Member 1 (WNT1) and downstream WNT pathway factors c-myc and cyclin D1. Dual-luciferase assay revealed WNT1 as a direct target of miR-130a-3p, and further the inhibitory effect of miR-130a-3p on c-myc and cyclin D1 was proved to be reversed by overexpressed WNT1. Collectively, miR-130a-3p inhibits CRC growth by directly targeting WNT1, and miR-130a-3p and WNT1 pathway-associated factors are defined as potential targets for CRC treatment.
format	article
author	Guang-Lin Song Ming Xiao Xiao-Ya Wan Jun Deng Jun-Da Ling Ying-Guo Tian Min Li Jie Yin Ren-Ying Zheng Yi Tang Gui-Yuan Liu
author_facet	Guang-Lin Song Ming Xiao Xiao-Ya Wan Jun Deng Jun-Da Ling Ying-Guo Tian Min Li Jie Yin Ren-Ying Zheng Yi Tang Gui-Yuan Liu
author_sort	Guang-Lin Song
title	MiR-130a-3p suppresses colorectal cancer growth by targeting Wnt Family Member 1 (WNT1)
title_short	MiR-130a-3p suppresses colorectal cancer growth by targeting Wnt Family Member 1 (WNT1)
title_full	MiR-130a-3p suppresses colorectal cancer growth by targeting Wnt Family Member 1 (WNT1)
title_fullStr	MiR-130a-3p suppresses colorectal cancer growth by targeting Wnt Family Member 1 (WNT1)
title_full_unstemmed	MiR-130a-3p suppresses colorectal cancer growth by targeting Wnt Family Member 1 (WNT1)
title_sort	mir-130a-3p suppresses colorectal cancer growth by targeting wnt family member 1 (wnt1)
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/76c01e9aaeb240299368b8ff0ba91578
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MiR-130a-3p suppresses colorectal cancer growth by targeting Wnt Family Member 1 (WNT1)

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