Efficacy Of Using Carbopol As An Adjuvant For Tissue Culture Inactivated Rabies Vaccine

In a trail to improve rabies vaccine's immunogenicity, water-soluble acrylic acid (carbopol) was used as an adjuvant in the prepared vaccine. The potency test of the National Institute of Health revealed that the prepared vaccine is potent and efficient. Studying the dynamics of serum antibody...

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Autores principales:	Naglaa, I. Aly, Omaima, A. A. Al-Shamandy, Shendy, M.B; Fatma, F. Warda; Ekbal, M. Farouk
Formato:	article
Lenguaje:	EN
Publicado:	Egyptian Society for Animal Management 2020
Materias:	carbopol elisa inactivated vaccine rabies Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801
Acceso en línea:	https://dx.doi.org/10.21608/javs.2020.103395 https://doaj.org/article/76c075e5564247a683ad07d2835c2001
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spelling	oai:doaj.org-article:76c075e5564247a683ad07d2835c20012021-12-02T16:33:51ZEfficacy Of Using Carbopol As An Adjuvant For Tissue Culture Inactivated Rabies Vaccinehttps://dx.doi.org/10.21608/javs.2020.1033951687-40722090-3308https://doaj.org/article/76c075e5564247a683ad07d2835c20012020-07-01T00:00:00Zhttps://javs.journals.ekb.eg/article_103395.htmlhttps://doaj.org/toc/1687-4072https://doaj.org/toc/2090-3308In a trail to improve rabies vaccine's immunogenicity, water-soluble acrylic acid (carbopol) was used as an adjuvant in the prepared vaccine. The potency test of the National Institute of Health revealed that the prepared vaccine is potent and efficient. Studying the dynamics of serum antibody in vaccinated dogs using serum neutralizing antibodies test and ELISA showed that antibody titer (0.9 and 1.2352 respectively) reached a level considered protective within two weeks and increased till lasted consist ant (2.4 and 2.694) during the experiment for about twenty-four weeks. In conclusion, the present study results indicated that the vaccine formulated according to this study procedure could provoke long-lasting protective immune response after a single dose administration without any adverse reaction. Naglaa, I. AlyOmaima, A. A. Al-ShamandyShendy, M.B; FatmaF. Warda; EkbalM. FaroukEgyptian Society for Animal Managementarticlecarbopolelisainactivated vaccinerabiesZoologyQL1-991Veterinary medicineSF600-1100Animal biochemistryQP501-801ENJournal of Applied Veterinary Sciences, Vol 5, Iss 3, Pp 103-107 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	carbopol elisa inactivated vaccine rabies Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801
spellingShingle	carbopol elisa inactivated vaccine rabies Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801 Naglaa, I. Aly Omaima, A. A. Al-Shamandy Shendy, M.B; Fatma F. Warda; Ekbal M. Farouk Efficacy Of Using Carbopol As An Adjuvant For Tissue Culture Inactivated Rabies Vaccine
description	In a trail to improve rabies vaccine's immunogenicity, water-soluble acrylic acid (carbopol) was used as an adjuvant in the prepared vaccine. The potency test of the National Institute of Health revealed that the prepared vaccine is potent and efficient. Studying the dynamics of serum antibody in vaccinated dogs using serum neutralizing antibodies test and ELISA showed that antibody titer (0.9 and 1.2352 respectively) reached a level considered protective within two weeks and increased till lasted consist ant (2.4 and 2.694) during the experiment for about twenty-four weeks. In conclusion, the present study results indicated that the vaccine formulated according to this study procedure could provoke long-lasting protective immune response after a single dose administration without any adverse reaction.
format	article
author	Naglaa, I. Aly Omaima, A. A. Al-Shamandy Shendy, M.B; Fatma F. Warda; Ekbal M. Farouk
author_facet	Naglaa, I. Aly Omaima, A. A. Al-Shamandy Shendy, M.B; Fatma F. Warda; Ekbal M. Farouk
author_sort	Naglaa, I. Aly
title	Efficacy Of Using Carbopol As An Adjuvant For Tissue Culture Inactivated Rabies Vaccine
title_short	Efficacy Of Using Carbopol As An Adjuvant For Tissue Culture Inactivated Rabies Vaccine
title_full	Efficacy Of Using Carbopol As An Adjuvant For Tissue Culture Inactivated Rabies Vaccine
title_fullStr	Efficacy Of Using Carbopol As An Adjuvant For Tissue Culture Inactivated Rabies Vaccine
title_full_unstemmed	Efficacy Of Using Carbopol As An Adjuvant For Tissue Culture Inactivated Rabies Vaccine
title_sort	efficacy of using carbopol as an adjuvant for tissue culture inactivated rabies vaccine
publisher	Egyptian Society for Animal Management
publishDate	2020
url	https://dx.doi.org/10.21608/javs.2020.103395 https://doaj.org/article/76c075e5564247a683ad07d2835c2001
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Efficacy Of Using Carbopol As An Adjuvant For Tissue Culture Inactivated Rabies Vaccine

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