Recent Advances in Studying Age-Associated Lipids Alterations and Dietary Interventions in Mammals

Lipids are involved in a broad spectrum of canonical biological functions, from energy supply and storage by triacylglycerols to membrane formation by sphingolipids, phospholipids and glycolipids. Because of this wide range of functions, there is an overlap between age-associated processes and lipid...

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Autores principales:	Benedikt Gille, Christina E. Galuska, Beate Fuchs, Shahaf Peleg
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	aging lipid healthy life span metabolism dietary intervention Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/76c0769431fa4430bcf3df9bc52dfc17
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spelling	oai:doaj.org-article:76c0769431fa4430bcf3df9bc52dfc172021-11-19T06:57:43ZRecent Advances in Studying Age-Associated Lipids Alterations and Dietary Interventions in Mammals2673-621710.3389/fragi.2021.773795https://doaj.org/article/76c0769431fa4430bcf3df9bc52dfc172021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fragi.2021.773795/fullhttps://doaj.org/toc/2673-6217Lipids are involved in a broad spectrum of canonical biological functions, from energy supply and storage by triacylglycerols to membrane formation by sphingolipids, phospholipids and glycolipids. Because of this wide range of functions, there is an overlap between age-associated processes and lipid pathways. Lipidome analysis revealed age-related changes in the lipid composition of various tissues in mice and humans, which were also influenced by diet and gender. Some changes in the lipid profile can be linked to the onset of age-related neurodegenerative diseases like Alzheimer’s disease. Furthermore, the excessive accumulation of lipid storage organelles, lipid droplets, has significant implications for the development of inflammaging and non-communicable age-related diseases. Dietary interventions such as caloric restriction, time-restrictive eating, and lipid supplementation have been shown to improve pertinent health metrics or even extend life span and thus modulate aging processes.Benedikt GilleChristina E. GaluskaBeate FuchsShahaf PelegShahaf PelegFrontiers Media S.A.articleaginglipidhealthy life spanmetabolismdietary interventionGeriatricsRC952-954.6ENFrontiers in Aging, Vol 2 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aging lipid healthy life span metabolism dietary intervention Geriatrics RC952-954.6
spellingShingle	aging lipid healthy life span metabolism dietary intervention Geriatrics RC952-954.6 Benedikt Gille Christina E. Galuska Beate Fuchs Shahaf Peleg Shahaf Peleg Recent Advances in Studying Age-Associated Lipids Alterations and Dietary Interventions in Mammals
description	Lipids are involved in a broad spectrum of canonical biological functions, from energy supply and storage by triacylglycerols to membrane formation by sphingolipids, phospholipids and glycolipids. Because of this wide range of functions, there is an overlap between age-associated processes and lipid pathways. Lipidome analysis revealed age-related changes in the lipid composition of various tissues in mice and humans, which were also influenced by diet and gender. Some changes in the lipid profile can be linked to the onset of age-related neurodegenerative diseases like Alzheimer’s disease. Furthermore, the excessive accumulation of lipid storage organelles, lipid droplets, has significant implications for the development of inflammaging and non-communicable age-related diseases. Dietary interventions such as caloric restriction, time-restrictive eating, and lipid supplementation have been shown to improve pertinent health metrics or even extend life span and thus modulate aging processes.
format	article
author	Benedikt Gille Christina E. Galuska Beate Fuchs Shahaf Peleg Shahaf Peleg
author_facet	Benedikt Gille Christina E. Galuska Beate Fuchs Shahaf Peleg Shahaf Peleg
author_sort	Benedikt Gille
title	Recent Advances in Studying Age-Associated Lipids Alterations and Dietary Interventions in Mammals
title_short	Recent Advances in Studying Age-Associated Lipids Alterations and Dietary Interventions in Mammals
title_full	Recent Advances in Studying Age-Associated Lipids Alterations and Dietary Interventions in Mammals
title_fullStr	Recent Advances in Studying Age-Associated Lipids Alterations and Dietary Interventions in Mammals
title_full_unstemmed	Recent Advances in Studying Age-Associated Lipids Alterations and Dietary Interventions in Mammals
title_sort	recent advances in studying age-associated lipids alterations and dietary interventions in mammals
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/76c0769431fa4430bcf3df9bc52dfc17
work_keys_str_mv	AT benediktgille recentadvancesinstudyingageassociatedlipidsalterationsanddietaryinterventionsinmammals AT christinaegaluska recentadvancesinstudyingageassociatedlipidsalterationsanddietaryinterventionsinmammals AT beatefuchs recentadvancesinstudyingageassociatedlipidsalterationsanddietaryinterventionsinmammals AT shahafpeleg recentadvancesinstudyingageassociatedlipidsalterationsanddietaryinterventionsinmammals AT shahafpeleg recentadvancesinstudyingageassociatedlipidsalterationsanddietaryinterventionsinmammals
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Recent Advances in Studying Age-Associated Lipids Alterations and Dietary Interventions in Mammals

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