RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis
Chronic myelomonocytic leukaemia is classified as proliferative (pCMML) or dysplastic based on the white blood cell counts but biological differences are unclear. Here, the authors show genetic, transcriptomic and epigenomic differences between these two subtypes establishing that pCMML is RAS-pathw...
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Nature Portfolio
2021
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oai:doaj.org-article:76c77b395be34b1d8dcd36a45fbde44e2021-12-02T16:51:30ZRAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis10.1038/s41467-021-23186-w2041-1723https://doaj.org/article/76c77b395be34b1d8dcd36a45fbde44e2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23186-whttps://doaj.org/toc/2041-1723Chronic myelomonocytic leukaemia is classified as proliferative (pCMML) or dysplastic based on the white blood cell counts but biological differences are unclear. Here, the authors show genetic, transcriptomic and epigenomic differences between these two subtypes establishing that pCMML is RAS-pathway driven and that inhibiting RAS-driven PLK1 expression is a viable therapeutic target.Ryan M. CarrDenis VorobyevTerra LashoDavid L. MarksEzequiel J. TolosaAlexis VedderLuciana L. AlmadaAndrey YurchekoIsmael PadioleauBonnie AlverGiacomo ColtroMoritz BinderStephanie L. SafgrenIsaac HornXiaona YouEric SolaryMaria E. BalasisKurt BergerJames HiebertThomas WitzigAjinkya BuradkarTemeida GrafPeter ValentAbhishek A. MangaonkarKeith D. RobertsonMatthew T. HowardScott H. KaufmannChristopher PinMartin E. Fernandez-ZapicoKlaus GeisslerNathalie DroinEric PadronJing ZhangSergey NikolaevMrinal M. PatnaikNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021) |
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Science Q Ryan M. Carr Denis Vorobyev Terra Lasho David L. Marks Ezequiel J. Tolosa Alexis Vedder Luciana L. Almada Andrey Yurcheko Ismael Padioleau Bonnie Alver Giacomo Coltro Moritz Binder Stephanie L. Safgren Isaac Horn Xiaona You Eric Solary Maria E. Balasis Kurt Berger James Hiebert Thomas Witzig Ajinkya Buradkar Temeida Graf Peter Valent Abhishek A. Mangaonkar Keith D. Robertson Matthew T. Howard Scott H. Kaufmann Christopher Pin Martin E. Fernandez-Zapico Klaus Geissler Nathalie Droin Eric Padron Jing Zhang Sergey Nikolaev Mrinal M. Patnaik RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis |
| description |
Chronic myelomonocytic leukaemia is classified as proliferative (pCMML) or dysplastic based on the white blood cell counts but biological differences are unclear. Here, the authors show genetic, transcriptomic and epigenomic differences between these two subtypes establishing that pCMML is RAS-pathway driven and that inhibiting RAS-driven PLK1 expression is a viable therapeutic target. |
| format |
article |
| author |
Ryan M. Carr Denis Vorobyev Terra Lasho David L. Marks Ezequiel J. Tolosa Alexis Vedder Luciana L. Almada Andrey Yurcheko Ismael Padioleau Bonnie Alver Giacomo Coltro Moritz Binder Stephanie L. Safgren Isaac Horn Xiaona You Eric Solary Maria E. Balasis Kurt Berger James Hiebert Thomas Witzig Ajinkya Buradkar Temeida Graf Peter Valent Abhishek A. Mangaonkar Keith D. Robertson Matthew T. Howard Scott H. Kaufmann Christopher Pin Martin E. Fernandez-Zapico Klaus Geissler Nathalie Droin Eric Padron Jing Zhang Sergey Nikolaev Mrinal M. Patnaik |
| author_facet |
Ryan M. Carr Denis Vorobyev Terra Lasho David L. Marks Ezequiel J. Tolosa Alexis Vedder Luciana L. Almada Andrey Yurcheko Ismael Padioleau Bonnie Alver Giacomo Coltro Moritz Binder Stephanie L. Safgren Isaac Horn Xiaona You Eric Solary Maria E. Balasis Kurt Berger James Hiebert Thomas Witzig Ajinkya Buradkar Temeida Graf Peter Valent Abhishek A. Mangaonkar Keith D. Robertson Matthew T. Howard Scott H. Kaufmann Christopher Pin Martin E. Fernandez-Zapico Klaus Geissler Nathalie Droin Eric Padron Jing Zhang Sergey Nikolaev Mrinal M. Patnaik |
| author_sort |
Ryan M. Carr |
| title |
RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis |
| title_short |
RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis |
| title_full |
RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis |
| title_fullStr |
RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis |
| title_full_unstemmed |
RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis |
| title_sort |
ras mutations drive proliferative chronic myelomonocytic leukemia via a kmt2a-plk1 axis |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/76c77b395be34b1d8dcd36a45fbde44e |
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