RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis

QR Code

RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis

Chronic myelomonocytic leukaemia is classified as proliferative (pCMML) or dysplastic based on the white blood cell counts but biological differences are unclear. Here, the authors show genetic, transcriptomic and epigenomic differences between these two subtypes establishing that pCMML is RAS-pathw...

Description complète

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Ryan M. Carr, Denis Vorobyev, Terra Lasho, David L. Marks, Ezequiel J. Tolosa, Alexis Vedder, Luciana L. Almada, Andrey Yurcheko, Ismael Padioleau, Bonnie Alver, Giacomo Coltro, Moritz Binder, Stephanie L. Safgren, Isaac Horn, Xiaona You, Eric Solary, Maria E. Balasis, Kurt Berger, James Hiebert, Thomas Witzig, Ajinkya Buradkar, Temeida Graf, Peter Valent, Abhishek A. Mangaonkar, Keith D. Robertson, Matthew T. Howard, Scott H. Kaufmann, Christopher Pin, Martin E. Fernandez-Zapico, Klaus Geissler, Nathalie Droin, Eric Padron, Jing Zhang, Sergey Nikolaev, Mrinal M. Patnaik
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/76c77b395be34b1d8dcd36a45fbde44e
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires

Mutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents
par: Jane Merlevede, et autres
Publié: (2016)

JUVENILE MYELOMONOCYTIC LEUKEMIA SINGLE CENTER EXPERIENCE
par: Yunus Murat Akcabelen, et autres
Publié: (2021)

Systemic mastocytosis associated with chronic myelomonocytic leukemia and xanthogranuloma
par: Philipp Tschandl, et autres
Publié: (2012)

Genome-wide DNA methylation is predictive of outcome in juvenile myelomonocytic leukemia
par: Elliot Stieglitz, et autres
Publié: (2017)

RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia
par: Daniel B. Lipka, et autres
Publié: (2017)

Long non-coding RNAs as novel therapeutic targets in juvenile myelomonocytic leukemia
par: Mattias Hofmans, et autres
Publié: (2021)

Rapid coupling between gravitational forces and the transcriptome in human myelomonocytic U937 cells
par: Cora S. Thiel, et autres
Publié: (2018)

Wiedemann–Steiner Syndrome with a Pathogenic Variant in <i>KMT2A</i> from Taiwan
par: Chung-Lin Lee, et autres
Publié: (2021)

KMT2D/MLL2 inactivation is associated with recurrence in adult-type granulosa cell tumors of the ovary
par: R. Tyler Hillman, et autres
Publié: (2018)

The low-complexity domains of the KMT2D protein regulate histone monomethylation transcription to facilitate pancreatic cancer progression
par: Weihan Li, et autres
Publié: (2021)

De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia
par: Axel Hyrenius-Wittsten, et autres
Publié: (2018)

Three de novo variants in KMT2A (MLL) identified by whole exome sequencing in patients with Wiedemann–Steiner syndrome
par: Sukun Luo, et autres
Publié: (2021)

Expression Analysis and Mutational Status of Histone Methyltransferase <i>KMT2D</i> at Different Upper Tract Urothelial Carcinoma Locations
par: Ekaterina Laukhtina, et autres
Publié: (2021)

Two new cases of interstitial 7q35q36.1 deletion including CNTNAP2 and KMT2C
par: Lucie Tosca, et autres
Publié: (2021)

Using patient-derived iPSCs to develop humanized mouse models for chronic myelomonocytic leukemia and therapeutic drug identification, including liposomal clodronate
par: Kazuki Taoka, et autres
Publié: (2018)

Conditionally immortalised leukaemia initiating cells co-expressing Hoxa9/Meis1 demonstrate microenvironmental adaptation properties ex vivo while maintaining myelomonocytic memory
par: Maike Stahlhut, et autres
Publié: (2021)

Morphologic characteristics of nevi associated with melanoma: a clinical, dermatoscopic and histopathologic analysis
par: Temeida Alendar, et autres
Publié: (2018)

O trabalho sob fogo cruzado: Ricardo Antunes e o maior imperativo de nosso tempo!
par: Fábio Luiz Zanardi Coltro
Publié: (2020)

A short caspase-3 isoform inhibits chemotherapy-induced apoptosis by blocking apoptosome assembly.
par: Frédérique Végran, et autres
Publié: (2011)

Outcome After Azacitidine Treatment in Patients with High-Risk Myeolodysplastic Syndrome, Chronic Myelomonocytic Leukemia Type 2 and Acute Myeloid Leukemia – A Single Center Experience (Preliminary Data)
par: Varbanova V., et autres
Publié: (2020)

Dynamic gene regulation by nuclear colony-stimulating factor 1 receptor in human monocytes and macrophages
par: Laura Bencheikh, et autres
Publié: (2019)

The Transcriptional Complex Sp1/KMT2A by Up-Regulating Restrictive Element 1 Silencing Transcription Factor Accelerates Methylmercury-Induced Cell Death in Motor Neuron-Like NSC34 Cells Overexpressing SOD1-G93A
par: Natascia Guida, et autres
Publié: (2021)

Trombosis venosa profunda y agenesia de vena cava inferior: presentación típica en una anomalía poco frecuente. Caso clínico
par: Castro L.,Fernanda, et autres
Publié: (2020)

Assessment and monitoring of patients receiving chemotherapy for multiple myeloma: strategies to improve outcomes
par: Faiman B, et autres
Publié: (2016)

Perceived discrimination during the childbirth hospitalization and postpartum visit attendance and content: Evidence from the Listening to Mothers in California survey.
par: Laura B Attanasio, et autres
Publié: (2021)

Building a Collaborative Editorial Workbench for Legal Texts with Complex Structures
par: Nils Geißler, et autres
Publié: (2020)

A miR-150/TET3 pathway regulates the generation of mouse and human non-classical monocyte subset
par: Dorothée Selimoglu-Buet, et autres
Publié: (2018)

XPC deficiency increases risk of hematologic malignancies through mutator phenotype and characteristic mutational signature
par: Andrey A. Yurchenko, et autres
Publié: (2020)

Adaptive neuro-fuzzy interference system modelling for chlorpyrifos removal with walnut shell biochar
par: Şevket Tulun, et autres
Publié: (2021)

Quantum approximate optimization for hard problems in linear algebra
par: Ajinkya Borle, Vincent E. Elfving, Samuel J. Lomonaco
Publié: (2021)

Epigenetic alteration contributes to the transcriptional reprogramming in T-cell prolymphocytic leukemia
par: Shulan Tian, et autres
Publié: (2021)

Shedding light on the prefrontal correlates of mental workload in simulated driving: a functional near-infrared spectroscopy study
par: Christoph F. Geissler, et autres
Publié: (2021)

Illuminating the prefrontal neural correlates of action sequence disassembling in response–response binding
par: Christoph F. Geissler, et autres
Publié: (2021)

Looking for a proxy of the ionospheric turbulence with Swarm data
par: Paola De Michelis, et autres
Publié: (2021)

Lab-on-chip analyser for the in situ determination of dissolved manganese in seawater
par: Felix Geißler, et autres
Publié: (2021)

Evaluation of healing at molar extraction sites with ridge preservation using a non‐resorbable dense polytetrafluoroethylene membrane: A four‐arm cohort prospective study
par: Arwa M. Al Hugail, et autres
Publié: (2021)

Forest land tax reductions – an effective payment for forest ecosystem services in Slovakia?
par: Báliková Klára, et autres
Publié: (2021)

A prospective cohort register-based study of chronic postsurgical pain and long-term use of pain medication after otorhinolaryngological surgery
par: Nina Graf, et autres
Publié: (2021)

The early drift of the Indian plate
par: Wilfried Jokat, et autres
Publié: (2021)

Optimizing Glass Design: The Role of Computational Wind Engineering & Advanced Numerical Analysis
par: Timothy R. Brewer, et autres
Publié: (2018)