Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders
The molecular mechanisms of neurotrophin receptor trafficking are only partially understood. Here the authors show that ARHGAP33 interacts with SORT1 to regulate TrkB trafficking, the dysfunction of which impairs synapse development and leads to schizophrenia-related behavioural abnormalities in mic...
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Nature Portfolio
2016
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oai:doaj.org-article:76c7f59a209646a0ada889e8e6621f222021-12-02T15:35:44ZEmerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders10.1038/ncomms105942041-1723https://doaj.org/article/76c7f59a209646a0ada889e8e6621f222016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10594https://doaj.org/toc/2041-1723The molecular mechanisms of neurotrophin receptor trafficking are only partially understood. Here the authors show that ARHGAP33 interacts with SORT1 to regulate TrkB trafficking, the dysfunction of which impairs synapse development and leads to schizophrenia-related behavioural abnormalities in mice.Takanobu NakazawaRyota HashimotoKazuto SakooriYuki SugayaAsami TanimuraYuki HashimotodaniKazutaka OhiHidenaga YamamoriYuka YasudaSatomi Umeda-YanoYuji KiyamaKohtarou KonnoTakeshi InoueKazumasa YokoyamaTakafumi InoueShusuke NumataTohru OhnumaNakao IwataNorio OzakiHitoshi HashimotoMasahiko WatanabeToshiya ManabeTadashi YamamotoMasatoshi TakedaMasanobu KanoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-17 (2016) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Science Q |
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Science Q Takanobu Nakazawa Ryota Hashimoto Kazuto Sakoori Yuki Sugaya Asami Tanimura Yuki Hashimotodani Kazutaka Ohi Hidenaga Yamamori Yuka Yasuda Satomi Umeda-Yano Yuji Kiyama Kohtarou Konno Takeshi Inoue Kazumasa Yokoyama Takafumi Inoue Shusuke Numata Tohru Ohnuma Nakao Iwata Norio Ozaki Hitoshi Hashimoto Masahiko Watanabe Toshiya Manabe Tadashi Yamamoto Masatoshi Takeda Masanobu Kano Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders |
| description |
The molecular mechanisms of neurotrophin receptor trafficking are only partially understood. Here the authors show that ARHGAP33 interacts with SORT1 to regulate TrkB trafficking, the dysfunction of which impairs synapse development and leads to schizophrenia-related behavioural abnormalities in mice. |
| format |
article |
| author |
Takanobu Nakazawa Ryota Hashimoto Kazuto Sakoori Yuki Sugaya Asami Tanimura Yuki Hashimotodani Kazutaka Ohi Hidenaga Yamamori Yuka Yasuda Satomi Umeda-Yano Yuji Kiyama Kohtarou Konno Takeshi Inoue Kazumasa Yokoyama Takafumi Inoue Shusuke Numata Tohru Ohnuma Nakao Iwata Norio Ozaki Hitoshi Hashimoto Masahiko Watanabe Toshiya Manabe Tadashi Yamamoto Masatoshi Takeda Masanobu Kano |
| author_facet |
Takanobu Nakazawa Ryota Hashimoto Kazuto Sakoori Yuki Sugaya Asami Tanimura Yuki Hashimotodani Kazutaka Ohi Hidenaga Yamamori Yuka Yasuda Satomi Umeda-Yano Yuji Kiyama Kohtarou Konno Takeshi Inoue Kazumasa Yokoyama Takafumi Inoue Shusuke Numata Tohru Ohnuma Nakao Iwata Norio Ozaki Hitoshi Hashimoto Masahiko Watanabe Toshiya Manabe Tadashi Yamamoto Masatoshi Takeda Masanobu Kano |
| author_sort |
Takanobu Nakazawa |
| title |
Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders |
| title_short |
Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders |
| title_full |
Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders |
| title_fullStr |
Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders |
| title_full_unstemmed |
Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders |
| title_sort |
emerging roles of arhgap33 in intracellular trafficking of trkb and pathophysiology of neuropsychiatric disorders |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/76c7f59a209646a0ada889e8e6621f22 |
| work_keys_str_mv |
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