A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival

A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival

Cytidine deaminase (CDA) deficiency leads to genome instability. Here the authors find a synthetic lethal interaction between CDA and the microtubule-associated protein Tau deficiencies, and report that Tau depletion affects rRNA synthesis, ribonucleotide pool balance, and rDNA stability.

Guardado en:
Detalles Bibliográficos
Autores principales: Elias Bou Samra, Géraldine Buhagiar-Labarchède, Christelle Machon, Jérôme Guitton, Rosine Onclercq-Delic, Michael R. Green, Olivier Alibert, Claude Gazin, Xavier Veaute, Mounira Amor-Guéret
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/76cbf3a2c1aa4ca09772fdb78864bf44
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:76cbf3a2c1aa4ca09772fdb78864bf44
record_format dspace
spelling oai:doaj.org-article:76cbf3a2c1aa4ca09772fdb78864bf442021-12-02T15:38:58ZA role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival10.1038/s41467-017-00633-12041-1723https://doaj.org/article/76cbf3a2c1aa4ca09772fdb78864bf442017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00633-1https://doaj.org/toc/2041-1723Cytidine deaminase (CDA) deficiency leads to genome instability. Here the authors find a synthetic lethal interaction between CDA and the microtubule-associated protein Tau deficiencies, and report that Tau depletion affects rRNA synthesis, ribonucleotide pool balance, and rDNA stability.Elias Bou SamraGéraldine Buhagiar-LabarchèdeChristelle MachonJérôme GuittonRosine Onclercq-DelicMichael R. GreenOlivier AlibertClaude GazinXavier VeauteMounira Amor-GuéretNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Elias Bou Samra
Géraldine Buhagiar-Labarchède
Christelle Machon
Jérôme Guitton
Rosine Onclercq-Delic
Michael R. Green
Olivier Alibert
Claude Gazin
Xavier Veaute
Mounira Amor-Guéret
A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival
description Cytidine deaminase (CDA) deficiency leads to genome instability. Here the authors find a synthetic lethal interaction between CDA and the microtubule-associated protein Tau deficiencies, and report that Tau depletion affects rRNA synthesis, ribonucleotide pool balance, and rDNA stability.
format article
author Elias Bou Samra
Géraldine Buhagiar-Labarchède
Christelle Machon
Jérôme Guitton
Rosine Onclercq-Delic
Michael R. Green
Olivier Alibert
Claude Gazin
Xavier Veaute
Mounira Amor-Guéret
author_facet Elias Bou Samra
Géraldine Buhagiar-Labarchède
Christelle Machon
Jérôme Guitton
Rosine Onclercq-Delic
Michael R. Green
Olivier Alibert
Claude Gazin
Xavier Veaute
Mounira Amor-Guéret
author_sort Elias Bou Samra
title A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival
title_short A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival
title_full A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival
title_fullStr A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival
title_full_unstemmed A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival
title_sort role for tau protein in maintaining ribosomal dna stability and cytidine deaminase-deficient cell survival
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/76cbf3a2c1aa4ca09772fdb78864bf44
work_keys_str_mv AT eliasbousamra arolefortauproteininmaintainingribosomaldnastabilityandcytidinedeaminasedeficientcellsurvival
AT geraldinebuhagiarlabarchede arolefortauproteininmaintainingribosomaldnastabilityandcytidinedeaminasedeficientcellsurvival
AT christellemachon arolefortauproteininmaintainingribosomaldnastabilityandcytidinedeaminasedeficientcellsurvival
AT jeromeguitton arolefortauproteininmaintainingribosomaldnastabilityandcytidinedeaminasedeficientcellsurvival
AT rosineonclercqdelic arolefortauproteininmaintainingribosomaldnastabilityandcytidinedeaminasedeficientcellsurvival
AT michaelrgreen arolefortauproteininmaintainingribosomaldnastabilityandcytidinedeaminasedeficientcellsurvival
AT olivieralibert arolefortauproteininmaintainingribosomaldnastabilityandcytidinedeaminasedeficientcellsurvival
AT claudegazin arolefortauproteininmaintainingribosomaldnastabilityandcytidinedeaminasedeficientcellsurvival
AT xavierveaute arolefortauproteininmaintainingribosomaldnastabilityandcytidinedeaminasedeficientcellsurvival
AT mouniraamorgueret arolefortauproteininmaintainingribosomaldnastabilityandcytidinedeaminasedeficientcellsurvival
AT eliasbousamra rolefortauproteininmaintainingribosomaldnastabilityandcytidinedeaminasedeficientcellsurvival
AT geraldinebuhagiarlabarchede rolefortauproteininmaintainingribosomaldnastabilityandcytidinedeaminasedeficientcellsurvival
AT christellemachon rolefortauproteininmaintainingribosomaldnastabilityandcytidinedeaminasedeficientcellsurvival
AT jeromeguitton rolefortauproteininmaintainingribosomaldnastabilityandcytidinedeaminasedeficientcellsurvival
AT rosineonclercqdelic rolefortauproteininmaintainingribosomaldnastabilityandcytidinedeaminasedeficientcellsurvival
AT michaelrgreen rolefortauproteininmaintainingribosomaldnastabilityandcytidinedeaminasedeficientcellsurvival
AT olivieralibert rolefortauproteininmaintainingribosomaldnastabilityandcytidinedeaminasedeficientcellsurvival
AT claudegazin rolefortauproteininmaintainingribosomaldnastabilityandcytidinedeaminasedeficientcellsurvival
AT xavierveaute rolefortauproteininmaintainingribosomaldnastabilityandcytidinedeaminasedeficientcellsurvival
AT mouniraamorgueret rolefortauproteininmaintainingribosomaldnastabilityandcytidinedeaminasedeficientcellsurvival
_version_ 1718385995568644096

Ejemplares similares