Role of Known Transient Receptor Potential Vanilloid Channels in Modulating Cardiac Mechanobiology

The transient receptor potential (TRP) channels have been described in almost every mammalian cell type. Several members of the Vanilloid (TRPV) subtype have been found to play important roles in modulating cardiac structure and function through Ca2+ handling in response to systemic and local mechan...

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Autores principales:	Michael Miller, Sheryl E. Koch, Adam Veteto, Timothy Domeier, Jack Rubinstein
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	TRPV channels hypertrophy cardiomyopathies fibrosis cardiac fibrosis Physiology QP1-981
Acceso en línea:	https://doaj.org/article/76cf874e081d450089f986e156d86824
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spelling	oai:doaj.org-article:76cf874e081d450089f986e156d868242021-11-16T18:38:13ZRole of Known Transient Receptor Potential Vanilloid Channels in Modulating Cardiac Mechanobiology1664-042X10.3389/fphys.2021.734113https://doaj.org/article/76cf874e081d450089f986e156d868242021-10-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.734113/fullhttps://doaj.org/toc/1664-042XThe transient receptor potential (TRP) channels have been described in almost every mammalian cell type. Several members of the Vanilloid (TRPV) subtype have been found to play important roles in modulating cardiac structure and function through Ca2+ handling in response to systemic and local mechanobiological cues. In this review, we will consider the most studied TRPV channels in the cardiovascular field; transient receptor potential vanilloid 1 as a modulator of cardiac hypertrophy; transient receptor potential vanilloid 2 as a structural and functional protein; transient receptor potential vanilloid 3 in the development of hypertrophy and myocardial fibrosis; and transient receptor potential vanilloid 4 in its roles modulating the fibrotic and functional responses of the heart to pressure overload. Lastly, we will also review the potential overlapping roles of these channels with other TRP proteins as well as the advances in translational and clinical arenas associated with TRPV channels.Michael MillerSheryl E. KochAdam VetetoAdam VetetoTimothy DomeierJack RubinsteinJack RubinsteinFrontiers Media S.A.articleTRPV channelshypertrophycardiomyopathiesfibrosiscardiac fibrosisPhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	TRPV channels hypertrophy cardiomyopathies fibrosis cardiac fibrosis Physiology QP1-981
spellingShingle	TRPV channels hypertrophy cardiomyopathies fibrosis cardiac fibrosis Physiology QP1-981 Michael Miller Sheryl E. Koch Adam Veteto Adam Veteto Timothy Domeier Jack Rubinstein Jack Rubinstein Role of Known Transient Receptor Potential Vanilloid Channels in Modulating Cardiac Mechanobiology
description	The transient receptor potential (TRP) channels have been described in almost every mammalian cell type. Several members of the Vanilloid (TRPV) subtype have been found to play important roles in modulating cardiac structure and function through Ca2+ handling in response to systemic and local mechanobiological cues. In this review, we will consider the most studied TRPV channels in the cardiovascular field; transient receptor potential vanilloid 1 as a modulator of cardiac hypertrophy; transient receptor potential vanilloid 2 as a structural and functional protein; transient receptor potential vanilloid 3 in the development of hypertrophy and myocardial fibrosis; and transient receptor potential vanilloid 4 in its roles modulating the fibrotic and functional responses of the heart to pressure overload. Lastly, we will also review the potential overlapping roles of these channels with other TRP proteins as well as the advances in translational and clinical arenas associated with TRPV channels.
format	article
author	Michael Miller Sheryl E. Koch Adam Veteto Adam Veteto Timothy Domeier Jack Rubinstein Jack Rubinstein
author_facet	Michael Miller Sheryl E. Koch Adam Veteto Adam Veteto Timothy Domeier Jack Rubinstein Jack Rubinstein
author_sort	Michael Miller
title	Role of Known Transient Receptor Potential Vanilloid Channels in Modulating Cardiac Mechanobiology
title_short	Role of Known Transient Receptor Potential Vanilloid Channels in Modulating Cardiac Mechanobiology
title_full	Role of Known Transient Receptor Potential Vanilloid Channels in Modulating Cardiac Mechanobiology
title_fullStr	Role of Known Transient Receptor Potential Vanilloid Channels in Modulating Cardiac Mechanobiology
title_full_unstemmed	Role of Known Transient Receptor Potential Vanilloid Channels in Modulating Cardiac Mechanobiology
title_sort	role of known transient receptor potential vanilloid channels in modulating cardiac mechanobiology
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/76cf874e081d450089f986e156d86824
work_keys_str_mv	AT michaelmiller roleofknowntransientreceptorpotentialvanilloidchannelsinmodulatingcardiacmechanobiology AT sherylekoch roleofknowntransientreceptorpotentialvanilloidchannelsinmodulatingcardiacmechanobiology AT adamveteto roleofknowntransientreceptorpotentialvanilloidchannelsinmodulatingcardiacmechanobiology AT adamveteto roleofknowntransientreceptorpotentialvanilloidchannelsinmodulatingcardiacmechanobiology AT timothydomeier roleofknowntransientreceptorpotentialvanilloidchannelsinmodulatingcardiacmechanobiology AT jackrubinstein roleofknowntransientreceptorpotentialvanilloidchannelsinmodulatingcardiacmechanobiology AT jackrubinstein roleofknowntransientreceptorpotentialvanilloidchannelsinmodulatingcardiacmechanobiology
_version_	1718426247877361664

Role of Known Transient Receptor Potential Vanilloid Channels in Modulating Cardiac Mechanobiology

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