Bidirectional association between periodontal disease and diabetes mellitus: a systematic review and meta-analysis of cohort studies

Abstract Periodontal disease has been reported to be associated with diabetes mellitus. However, the direction of the association and the influence of bias are not clear. Thus, the aim of this systematic review and meta-analysis was to summarize the existing evidence on the bidirectional prospective...

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Autores principales:	Julia Stöhr, Janett Barbaresko, Manuela Neuenschwander, Sabrina Schlesinger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/76d7538aa6784125bbaf6870b2ad38d5
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spelling	oai:doaj.org-article:76d7538aa6784125bbaf6870b2ad38d52021-12-02T14:33:51ZBidirectional association between periodontal disease and diabetes mellitus: a systematic review and meta-analysis of cohort studies10.1038/s41598-021-93062-62045-2322https://doaj.org/article/76d7538aa6784125bbaf6870b2ad38d52021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93062-6https://doaj.org/toc/2045-2322Abstract Periodontal disease has been reported to be associated with diabetes mellitus. However, the direction of the association and the influence of bias are not clear. Thus, the aim of this systematic review and meta-analysis was to summarize the existing evidence on the bidirectional prospective association between periodontal disease and diabetes mellitus by accounting for the risk of bias of the original studies. The literature search was conducted on the electronic data sources PubMed and Web of Science up to February 9th, 2021. We included observational studies, which investigated the prospective association between diabetes mellitus and periodontal disease or vice versa. The risk of bias of the primary studies was evaluated by applying the Quality in Prognosis Studies (QUIPS) tool. Random effects models were used to calculate summary relative risk (SRR) with 95% CI. Subgroup analyses were applied to investigate heterogeneity and the robustness of the finding. In total, 15 studies were included . The SRR for incident diabetes mellitus was 1.26 (95% CI 1.12, 1.41; I2: 71%, n = 10; participants = 427,620; identified cases = 114,361), when comparing individuals with periodontitis to individuals without periodontitis. The SRR for incident periodontitis was 1.24 (95% CI 1.13, 1.37; I2: 92%, n = 7; participants = 295,804; identified cases: > 22,500), comparing individuals with diabetes to individuals without diabetes. There were no significant differences between subgroups after stratification for risk of bias. The findings show a positive bidirectional association between periodontal disease and diabetes mellitus, and thus, underline the need for screening of patients with periodontitis regarding diabetes mellitus and vice versa. The main limitation of the study is the high unexplained heterogeneity between the studies including the different assessment methods of the disease diagnosis.Julia StöhrJanett BarbareskoManuela NeuenschwanderSabrina SchlesingerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Julia Stöhr Janett Barbaresko Manuela Neuenschwander Sabrina Schlesinger Bidirectional association between periodontal disease and diabetes mellitus: a systematic review and meta-analysis of cohort studies
description	Abstract Periodontal disease has been reported to be associated with diabetes mellitus. However, the direction of the association and the influence of bias are not clear. Thus, the aim of this systematic review and meta-analysis was to summarize the existing evidence on the bidirectional prospective association between periodontal disease and diabetes mellitus by accounting for the risk of bias of the original studies. The literature search was conducted on the electronic data sources PubMed and Web of Science up to February 9th, 2021. We included observational studies, which investigated the prospective association between diabetes mellitus and periodontal disease or vice versa. The risk of bias of the primary studies was evaluated by applying the Quality in Prognosis Studies (QUIPS) tool. Random effects models were used to calculate summary relative risk (SRR) with 95% CI. Subgroup analyses were applied to investigate heterogeneity and the robustness of the finding. In total, 15 studies were included . The SRR for incident diabetes mellitus was 1.26 (95% CI 1.12, 1.41; I2: 71%, n = 10; participants = 427,620; identified cases = 114,361), when comparing individuals with periodontitis to individuals without periodontitis. The SRR for incident periodontitis was 1.24 (95% CI 1.13, 1.37; I2: 92%, n = 7; participants = 295,804; identified cases: > 22,500), comparing individuals with diabetes to individuals without diabetes. There were no significant differences between subgroups after stratification for risk of bias. The findings show a positive bidirectional association between periodontal disease and diabetes mellitus, and thus, underline the need for screening of patients with periodontitis regarding diabetes mellitus and vice versa. The main limitation of the study is the high unexplained heterogeneity between the studies including the different assessment methods of the disease diagnosis.
format	article
author	Julia Stöhr Janett Barbaresko Manuela Neuenschwander Sabrina Schlesinger
author_facet	Julia Stöhr Janett Barbaresko Manuela Neuenschwander Sabrina Schlesinger
author_sort	Julia Stöhr
title	Bidirectional association between periodontal disease and diabetes mellitus: a systematic review and meta-analysis of cohort studies
title_short	Bidirectional association between periodontal disease and diabetes mellitus: a systematic review and meta-analysis of cohort studies
title_full	Bidirectional association between periodontal disease and diabetes mellitus: a systematic review and meta-analysis of cohort studies
title_fullStr	Bidirectional association between periodontal disease and diabetes mellitus: a systematic review and meta-analysis of cohort studies
title_full_unstemmed	Bidirectional association between periodontal disease and diabetes mellitus: a systematic review and meta-analysis of cohort studies
title_sort	bidirectional association between periodontal disease and diabetes mellitus: a systematic review and meta-analysis of cohort studies
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/76d7538aa6784125bbaf6870b2ad38d5
work_keys_str_mv	AT juliastohr bidirectionalassociationbetweenperiodontaldiseaseanddiabetesmellitusasystematicreviewandmetaanalysisofcohortstudies AT janettbarbaresko bidirectionalassociationbetweenperiodontaldiseaseanddiabetesmellitusasystematicreviewandmetaanalysisofcohortstudies AT manuelaneuenschwander bidirectionalassociationbetweenperiodontaldiseaseanddiabetesmellitusasystematicreviewandmetaanalysisofcohortstudies AT sabrinaschlesinger bidirectionalassociationbetweenperiodontaldiseaseanddiabetesmellitusasystematicreviewandmetaanalysisofcohortstudies
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Bidirectional association between periodontal disease and diabetes mellitus: a systematic review and meta-analysis of cohort studies

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