The effect of natural selection on the propagation of protein expression noise to bacterial growth.

In bacterial cells, protein expression is a highly stochastic process. Gene expression noise moreover propagates through the cell and adds to fluctuations in the cellular growth rate. A common intuition is that, due to their relatively high noise amplitudes, proteins with a low mean expression level...

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Autores principales:	Laurens H J Krah, Rutger Hermsen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/76d776ae82034af4972a3d311934b98b
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spelling	oai:doaj.org-article:76d776ae82034af4972a3d311934b98b2021-12-02T19:57:24ZThe effect of natural selection on the propagation of protein expression noise to bacterial growth.1553-734X1553-735810.1371/journal.pcbi.1009208https://doaj.org/article/76d776ae82034af4972a3d311934b98b2021-07-01T00:00:00Zhttps://doi.org/10.1371/journal.pcbi.1009208https://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358In bacterial cells, protein expression is a highly stochastic process. Gene expression noise moreover propagates through the cell and adds to fluctuations in the cellular growth rate. A common intuition is that, due to their relatively high noise amplitudes, proteins with a low mean expression level are the most important drivers of fluctuations in physiological variables. In this work, we challenge this intuition by considering the effect of natural selection on noise propagation. Mathematically, the contribution of each protein species to the noise in the growth rate depends on two factors: the noise amplitude of the protein's expression level, and the sensitivity of the growth rate to fluctuations in that protein's concentration. We argue that natural selection, while shaping mean abundances to increase the mean growth rate, also affects cellular sensitivities. In the limit in which cells grow optimally fast, the growth rate becomes most sensitive to fluctuations in highly abundant proteins. This causes abundant proteins to overall contribute strongly to the noise in the growth rate, despite their low noise levels. We further explore this result in an experimental data set of protein abundances, and test key assumptions in an evolving, stochastic toy model of cellular growth.Laurens H J KrahRutger HermsenPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 17, Iss 7, p e1009208 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Laurens H J Krah Rutger Hermsen The effect of natural selection on the propagation of protein expression noise to bacterial growth.
description	In bacterial cells, protein expression is a highly stochastic process. Gene expression noise moreover propagates through the cell and adds to fluctuations in the cellular growth rate. A common intuition is that, due to their relatively high noise amplitudes, proteins with a low mean expression level are the most important drivers of fluctuations in physiological variables. In this work, we challenge this intuition by considering the effect of natural selection on noise propagation. Mathematically, the contribution of each protein species to the noise in the growth rate depends on two factors: the noise amplitude of the protein's expression level, and the sensitivity of the growth rate to fluctuations in that protein's concentration. We argue that natural selection, while shaping mean abundances to increase the mean growth rate, also affects cellular sensitivities. In the limit in which cells grow optimally fast, the growth rate becomes most sensitive to fluctuations in highly abundant proteins. This causes abundant proteins to overall contribute strongly to the noise in the growth rate, despite their low noise levels. We further explore this result in an experimental data set of protein abundances, and test key assumptions in an evolving, stochastic toy model of cellular growth.
format	article
author	Laurens H J Krah Rutger Hermsen
author_facet	Laurens H J Krah Rutger Hermsen
author_sort	Laurens H J Krah
title	The effect of natural selection on the propagation of protein expression noise to bacterial growth.
title_short	The effect of natural selection on the propagation of protein expression noise to bacterial growth.
title_full	The effect of natural selection on the propagation of protein expression noise to bacterial growth.
title_fullStr	The effect of natural selection on the propagation of protein expression noise to bacterial growth.
title_full_unstemmed	The effect of natural selection on the propagation of protein expression noise to bacterial growth.
title_sort	effect of natural selection on the propagation of protein expression noise to bacterial growth.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/76d776ae82034af4972a3d311934b98b
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The effect of natural selection on the propagation of protein expression noise to bacterial growth.

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