Liver Injury in Patients with Coronavirus Disease 2019 (COVID-19)—A Narrative Review

While respiratory symptoms are prevalent in SARS-CoV-2 infected patients, growing evidence indicates that COVID-19 affects a wide variety of organs. Coronaviruses affect not only the respiratory system, but also the circulatory, nervous and digestive systems. The most common comorbidities in COVID-1...

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Autores principales:	Liliana Łykowska-Szuber, Karolina Wołodźko, Anna Maria Rychter, Aleksandra Szymczak-Tomczak, Iwona Krela-Kaźmierczak, Agnieszka Dobrowolska
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	COVID-19 liver disease clinical manifestations Medicine R
Acceso en línea:	https://doaj.org/article/76d81dcb835944bdaec7ad3215e050e6
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spelling	oai:doaj.org-article:76d81dcb835944bdaec7ad3215e050e62021-11-11T17:40:08ZLiver Injury in Patients with Coronavirus Disease 2019 (COVID-19)—A Narrative Review10.3390/jcm102150482077-0383https://doaj.org/article/76d81dcb835944bdaec7ad3215e050e62021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5048https://doaj.org/toc/2077-0383While respiratory symptoms are prevalent in SARS-CoV-2 infected patients, growing evidence indicates that COVID-19 affects a wide variety of organs. Coronaviruses affect not only the respiratory system, but also the circulatory, nervous and digestive systems. The most common comorbidities in COVID-19 patients are hypertension, followed by diabetes, cardiovascular, and respiratory disease. Most conditions predisposing to SARS-CoV-2 infection are closely related to the metabolic syndrome. Obesity and chronic diseases, including liver disease, are associated with the induction of pro-inflammatory conditions and a reduction in immune response disorders, leading to the suspicion that these conditions may increase the susceptibility to SARS-CoV2 infection and the risk of complications. The definition of liver damage caused by COVID-19 has not yet been established. COVID-19 may contribute to both primary and secondary liver injury in people with pre-existing chronic disease and impaired liver reserves, leading to exacerbation of underlying disease, liver decompensation, or acute chronic liver failure. Therefore, many researchers have interpreted it as clinical or laboratory abnormalities in the course of the disease and treatment in patients with or without pre-existing liver disease. The research results available so far indicate that patients with liver disease require special attention in the event of COVID-19 infection.Liliana Łykowska-SzuberKarolina WołodźkoAnna Maria RychterAleksandra Szymczak-TomczakIwona Krela-KaźmierczakAgnieszka DobrowolskaMDPI AGarticleCOVID-19liver diseaseclinical manifestationsMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5048, p 5048 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 liver disease clinical manifestations Medicine R
spellingShingle	COVID-19 liver disease clinical manifestations Medicine R Liliana Łykowska-Szuber Karolina Wołodźko Anna Maria Rychter Aleksandra Szymczak-Tomczak Iwona Krela-Kaźmierczak Agnieszka Dobrowolska Liver Injury in Patients with Coronavirus Disease 2019 (COVID-19)—A Narrative Review
description	While respiratory symptoms are prevalent in SARS-CoV-2 infected patients, growing evidence indicates that COVID-19 affects a wide variety of organs. Coronaviruses affect not only the respiratory system, but also the circulatory, nervous and digestive systems. The most common comorbidities in COVID-19 patients are hypertension, followed by diabetes, cardiovascular, and respiratory disease. Most conditions predisposing to SARS-CoV-2 infection are closely related to the metabolic syndrome. Obesity and chronic diseases, including liver disease, are associated with the induction of pro-inflammatory conditions and a reduction in immune response disorders, leading to the suspicion that these conditions may increase the susceptibility to SARS-CoV2 infection and the risk of complications. The definition of liver damage caused by COVID-19 has not yet been established. COVID-19 may contribute to both primary and secondary liver injury in people with pre-existing chronic disease and impaired liver reserves, leading to exacerbation of underlying disease, liver decompensation, or acute chronic liver failure. Therefore, many researchers have interpreted it as clinical or laboratory abnormalities in the course of the disease and treatment in patients with or without pre-existing liver disease. The research results available so far indicate that patients with liver disease require special attention in the event of COVID-19 infection.
format	article
author	Liliana Łykowska-Szuber Karolina Wołodźko Anna Maria Rychter Aleksandra Szymczak-Tomczak Iwona Krela-Kaźmierczak Agnieszka Dobrowolska
author_facet	Liliana Łykowska-Szuber Karolina Wołodźko Anna Maria Rychter Aleksandra Szymczak-Tomczak Iwona Krela-Kaźmierczak Agnieszka Dobrowolska
author_sort	Liliana Łykowska-Szuber
title	Liver Injury in Patients with Coronavirus Disease 2019 (COVID-19)—A Narrative Review
title_short	Liver Injury in Patients with Coronavirus Disease 2019 (COVID-19)—A Narrative Review
title_full	Liver Injury in Patients with Coronavirus Disease 2019 (COVID-19)—A Narrative Review
title_fullStr	Liver Injury in Patients with Coronavirus Disease 2019 (COVID-19)—A Narrative Review
title_full_unstemmed	Liver Injury in Patients with Coronavirus Disease 2019 (COVID-19)—A Narrative Review
title_sort	liver injury in patients with coronavirus disease 2019 (covid-19)—a narrative review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/76d81dcb835944bdaec7ad3215e050e6
work_keys_str_mv	AT lilianałykowskaszuber liverinjuryinpatientswithcoronavirusdisease2019covid19anarrativereview AT karolinawołodzko liverinjuryinpatientswithcoronavirusdisease2019covid19anarrativereview AT annamariarychter liverinjuryinpatientswithcoronavirusdisease2019covid19anarrativereview AT aleksandraszymczaktomczak liverinjuryinpatientswithcoronavirusdisease2019covid19anarrativereview AT iwonakrelakazmierczak liverinjuryinpatientswithcoronavirusdisease2019covid19anarrativereview AT agnieszkadobrowolska liverinjuryinpatientswithcoronavirusdisease2019covid19anarrativereview
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Liver Injury in Patients with Coronavirus Disease 2019 (COVID-19)—A Narrative Review

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