Silencing long ascending propriospinal neurons after spinal cord injury improves hindlimb stepping in the adult rat

Silencing long ascending propriospinal neurons after spinal cord injury improves hindlimb stepping in the adult rat

Long ascending propriospinal neurons (LAPNs) are a subpopulation of spinal cord interneurons that directly connect the lumbar and cervical enlargements. Previously we showed, in uninjured animals, that conditionally silencing LAPNs disrupted left-right coordination of the hindlimbs and forelimbs in...

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Bibliographic Details
Main Authors: Courtney T Shepard, Amanda M Pocratsky, Brandon L Brown, Morgan A Van Rijswijck, Rachel M Zalla, Darlene A Burke, Johnny R Morehouse, Amberley S Riegler, Scott R Whittemore, David SK Magnuson
Format: article
Language:EN
Published: eLife Sciences Publications Ltd 2021
Subjects:
spinal cord injury
propriospinal neurons
locomotion
viral vector
neuronal silencing
Medicine
R
Science
Q
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/76d9111e10d94c34bf93f809c60aae3d
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https://doaj.org/article/76d9111e10d94c34bf93f809c60aae3d

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