Dynamical adaptation in photoreceptors.

Adaptation is at the heart of sensation and nowhere is it more salient than in early visual processing. Light adaptation in photoreceptors is doubly dynamical: it depends upon the temporal structure of the input and it affects the temporal structure of the response. We introduce a non-linear dynamic...

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Autores principales:	Damon A Clark, Raphael Benichou, Markus Meister, Rava Azeredo da Silveira
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/76da3517232a4df0b38d3b0f594e8485
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spelling	oai:doaj.org-article:76da3517232a4df0b38d3b0f594e84852021-11-18T05:53:24ZDynamical adaptation in photoreceptors.1553-734X1553-735810.1371/journal.pcbi.1003289https://doaj.org/article/76da3517232a4df0b38d3b0f594e84852013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24244119/pdf/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Adaptation is at the heart of sensation and nowhere is it more salient than in early visual processing. Light adaptation in photoreceptors is doubly dynamical: it depends upon the temporal structure of the input and it affects the temporal structure of the response. We introduce a non-linear dynamical adaptation model of photoreceptors. It is simple enough that it can be solved exactly and simulated with ease; analytical and numerical approaches combined provide both intuition on the behavior of dynamical adaptation and quantitative results to be compared with data. Yet the model is rich enough to capture intricate phenomenology. First, we show that it reproduces the known phenomenology of light response and short-term adaptation. Second, we present new recordings and demonstrate that the model reproduces cone response with great precision. Third, we derive a number of predictions on the response of photoreceptors to sophisticated stimuli such as periodic inputs, various forms of flickering inputs, and natural inputs. In particular, we demonstrate that photoreceptors undergo rapid adaptation of response gain and time scale, over ∼ 300[Formula: see text] ms-i. e., over the time scale of the response itself-and we confirm this prediction with data. For natural inputs, this fast adaptation can modulate the response gain more than tenfold and is hence physiologically relevant.Damon A ClarkRaphael BenichouMarkus MeisterRava Azeredo da SilveiraPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 9, Iss 11, p e1003289 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Damon A Clark Raphael Benichou Markus Meister Rava Azeredo da Silveira Dynamical adaptation in photoreceptors.
description	Adaptation is at the heart of sensation and nowhere is it more salient than in early visual processing. Light adaptation in photoreceptors is doubly dynamical: it depends upon the temporal structure of the input and it affects the temporal structure of the response. We introduce a non-linear dynamical adaptation model of photoreceptors. It is simple enough that it can be solved exactly and simulated with ease; analytical and numerical approaches combined provide both intuition on the behavior of dynamical adaptation and quantitative results to be compared with data. Yet the model is rich enough to capture intricate phenomenology. First, we show that it reproduces the known phenomenology of light response and short-term adaptation. Second, we present new recordings and demonstrate that the model reproduces cone response with great precision. Third, we derive a number of predictions on the response of photoreceptors to sophisticated stimuli such as periodic inputs, various forms of flickering inputs, and natural inputs. In particular, we demonstrate that photoreceptors undergo rapid adaptation of response gain and time scale, over ∼ 300[Formula: see text] ms-i. e., over the time scale of the response itself-and we confirm this prediction with data. For natural inputs, this fast adaptation can modulate the response gain more than tenfold and is hence physiologically relevant.
format	article
author	Damon A Clark Raphael Benichou Markus Meister Rava Azeredo da Silveira
author_facet	Damon A Clark Raphael Benichou Markus Meister Rava Azeredo da Silveira
author_sort	Damon A Clark
title	Dynamical adaptation in photoreceptors.
title_short	Dynamical adaptation in photoreceptors.
title_full	Dynamical adaptation in photoreceptors.
title_fullStr	Dynamical adaptation in photoreceptors.
title_full_unstemmed	Dynamical adaptation in photoreceptors.
title_sort	dynamical adaptation in photoreceptors.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/76da3517232a4df0b38d3b0f594e8485
work_keys_str_mv	AT damonaclark dynamicaladaptationinphotoreceptors AT raphaelbenichou dynamicaladaptationinphotoreceptors AT markusmeister dynamicaladaptationinphotoreceptors AT ravaazeredodasilveira dynamicaladaptationinphotoreceptors
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Dynamical adaptation in photoreceptors.

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