New developments in the management of hepatitis C virus infection: focus on boceprevir
Marina Berenguer,1–3 F Xavier López-Labrador4–61Hepatology-Liver Transplantation Unit, Digestive Medicine Service, Hospital Universitari La Fe, Valencia, Spain; 2Department of Medicine, University of Valencia, Valencia, Spain; 3CIBERehd, Instituto de Salud...
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| Main Authors: | , |
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| Format: | article |
| Language: | EN |
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Dove Medical Press
2012
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| Subjects: | |
| Online Access: | https://doaj.org/article/76dc9770a0764ccb96417a8c9b27b59f |
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| Summary: | Marina Berenguer,1–3 F Xavier López-Labrador4–61Hepatology-Liver Transplantation Unit, Digestive Medicine Service, Hospital Universitari La Fe, Valencia, Spain; 2Department of Medicine, University of Valencia, Valencia, Spain; 3CIBERehd, Instituto de Salud Carlos III, Madrid, Spain; 4CSISP, Center for Public Health Research, Public Health Department, Generalitat Valenciana, Valencia, Spain; 5Microbiology Department and Institut Cavanilles, University of Valencia, Valencia, Spain; 6CIBEResp, Instituto de Salud Carlos III, Madrid, SpainAbstract: Chronic hepatitis C virus infection is an important public health problem, and the standard treatment (combination of pegylated interferon-α and ribavirin) has an effectiveness rate of only 40%–50%. Novel virus-specific drugs have recently been designed, and multiple compounds are under development. The approval for the clinical use of direct-acting antivirals in 2011 (boceprevir [BOC] and telaprevir, viral NS3 protease inhibitors) has increased recovery rates by up to 70%. Therefore, a highly effective treatment has been envisioned for the first time. This paper focuses on BOC and the implementation of new BOC-based treatment regimes.Keywords: HCV, antiviral therapy, protease inhibitors, viral resistance |
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